Expression of BDNF-Associated lncRNAs in Parkinson’s disease

The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement

“…Simultaneously, circ_0070441 can directly bind to miR-626, thereby indirectly regulating IRS2 expression, and its upregulation was verified to aggregate MPP(+)-induced neurotoxicity in a PD cell model [205]. However, there is still a controversial issue about whether circRNAs can serve as miRNA sponges because some studies have revealed that most circRNAs do not have the function of sponging miRNAs [211] (Figure 5). miRNAs are enriched in the brain tissue and play an essential role in the pathogenesis of Parkinson's disease; therefore, they have been considered as potential diagnostic biomarkers.…”

“…Previous studies have proposed five different ways of miRNA transportation into extracellular fluid: bound with high-density lipoprotein complex particles in non-vesicle form, formed into complexes with multiple proteins (Ago2 and NPM1), packaged within exosomes, encapsulated within microvesicles (MVs), and accumulated in apoptotic bodies [ 208 ]. Exosomes have the potential to cross the blood–brain barrier via the membrane fusion process; therefore, miRNAs packaged within exosomes could also be considered as potential treatment targets [ 209 , 210 , 211 , 212 ]. Changing the expression profiles of miRNAs under pathogenetic and physiological states and their transportability through the brain–blood barrier have promoted the study of their potential application as biomarkers of Parkinson’s disease to diagnose at an early stage and identify new therapeutic targets ( Table 5 ).…”

Circulating brain‐derived neurotrophic factor dysregulation and its linkage with lipid level, stenosis degree, and inflammatory cytokines in coronary heart disease

“…Brain-derived neurotrophic factor (BDNF) expressed in the mammalian brain widely may regulate neuronal survival, morphogenesis, and plasticity in multiple pathways. [11][12][13] Recently, BDNF has been widely reported to be involved in regulating several biological processes associated with the onset of CHD such as the abnormal lipid metabolism, formation of atherosclerosis plaque, inflammatory process dysregulation, and adhesion molecules production.. [14][15][16] For instance, one study shows that the production of BDNF might enhance lipid metabolism 14 ; another study discloses that the activation of BDNF could help to confer protection against atherosclerosis 15 ; apart from that, BDNF reduces the inflammation induced by the oxygenglucose deprivation and reoxygenation (OGD/R). 16 Based on what is mentioned above, we hypothesized that the BDNF might be a protective role in the pathogenesis of CHD, and its measurement may be useful for the clinical management of CHD.…”

“…Brain‐derived neurotrophic factor (BDNF) expressed in the mammalian brain widely may regulate neuronal survival, morphogenesis, and plasticity in multiple pathways 11–13 . Recently, BDNF has been widely reported to be involved in regulating several biological processes associated with the onset of CHD such as the abnormal lipid metabolism, formation of atherosclerosis plaque, inflammatory process dysregulation, and adhesion molecules production.…”

Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance

“…MIAT was initially identified as a myocardial infarction–associated transcript ( 23 ) that more recently has been identified to be especially enriched in neural tissues and has been associated with various diseases including schizophrenia and Parkinson’s disease ( 24 – 26 ). Mice genetically deficient in Miat were found to be fertile and generally healthy with only a mild hyperactivity phenotype ( 27 ).…”