Expression of BDNF and TrkB mRNAs in the crista neurosensory epithelium and vestibular ganglia following ototoxic damage

Popper, Paul; López, Iván; Beizai, Pouneh; Li, G.; Kim, J.; Micevych, Paul E.; Honrubia, Vicente

doi:10.1016/s0006-8993(99)01941-1

Cited by 16 publications

(20 citation statements)

References 47 publications

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“…Reports that TRPV1 mRNA is up-regulated in dorsal root ganglia by glial cell line-derived neurotrophic factor (GDNF) (Ogun-Muyiwa et al, 1999) and NGF (Ji et al, 2002;Winston et al, 2001) treatment further suggest that TRPV1 up-regulation may be a growth factormediated neuroprotective mechanism in dorsal root ganglion cells. A similar growth factor-mediated process is plausible in the spiral and vestibular ganglia: BDNF is expressed constitutively by SG cells and BDNF mRNA is up-regulated transiently in VG cells after unilateral aminoglycoside (gentamicin) instillation into perilymph (Popper et al, 1999).…”

Section: Discussionmentioning

confidence: 96%

Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge

Kitahara

Balaban

2005

Hearing Research

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Section: Discussionmentioning

confidence: 96%

Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge

Kitahara

Balaban

2005

Hearing Research

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“…One possibility is that factors required for initial nerve innervation of taste buds, like neurotrophins, are also involved in regeneration. This idea is supported by the findings that nerve injury is accompanied by an increase of neurotrophin expression (Hirsch et al 2000;Ji et al 2013;Popper et al 1999). In addition, exogenous application of neurotrophins can enhance regeneration in many systems, like axons of retinal ganglion cells (Cui et al 1998), sensory axons of spinal cord (Bradbury et al 1999;Ramer et al 2000), etc.…”

Section: Introductionmentioning

confidence: 84%

“…Neurotrophin expression increased in the cell bodies of the neurons whose nerves were sectioned in many sensory systems (Ha et al 2001;Hirsch et al 2000;Popper et al 1999;Zhou et al 1999). For example, in the visual system, the number of BDNF-positive retinal ganglion cells increased 2 fold at 2 days after optic fiber section in adult mice (Hirsch et al 2000); in the somatosensory system, BDNF expression in the dorsal root ganglion significantly increased 1 day after nerve lesion and lasted for 2 weeks (Zhou et al 1999).…”

Section: Potential Roles Of Neurotrophin In Gustatory Nerve Regeneratmentioning

confidence: 99%

Role of neurotrophin in the taste system following gustatory nerve injury

Meng

Jiang

2014

Metab Brain Dis

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Taste system is a perfect system to study degeneration and regeneration after nerve injury because the taste system is highly plastic and the regeneration is robust. Besides, degeneration and regeneration can be easily measured since taste buds arise in discrete locations, and nerves that innervate them can be accurately quantified. Neurotrophins are a family of proteins that regulate neural survival, function, and plasticity after nerve injury. Recent studies have shown that neurotrophins play an important role in the developmental and mature taste system, indicating neurtrophin might also regulate taste system following gustatory nerve injury. This review will summarize how taste system degenerates and regenerates after gustatory nerve cut and conclude potential roles of neurotrophin in regulating the process.

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“…BDNF also promotes neuronal survival and neurite sprouting in early post-natal rat vestibular ganglion neurons (Inoue et al 2014). Furthermore, vestibular ganglia repair and neurite outgrowth towards hair cells after ototoxic damage in chinchillas was also regulated by BDNF, while TrkB levels remained unchanged (Popper et al 1999). In patients with hearing loss, BDNF gene therapy treatment has been shown to override the genetic defect, leading to a new formation of the auditory neurons with a pronounced neural sprouting into the auditory epithelium despite missing hair cells.…”

Section: Introductionmentioning

confidence: 97%

Role of BDNF and neurotrophic receptors in human inner ear development

et al. 2017

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The expression patterns of the neurotrophin, brain-derived neurotrophic factor, BDNF, and the neurotrophic receptors-p75NTR and Trk receptors-in the developing human fetal inner ear between the gestational weeks (GW) 9 to 12 are examined via in situ hybridization and immunohistochemistry. BDNF mRNA expression was highest in the cochlea at GW 9 but declined in the course of development. In contrast to embryonic murine specimens, a decline in BDNF expression from the apical to the basal turn of the cochlea could not be observed. p75NTR immunostaining was most prominent in the nerve fibers that penetrate into the sensory epithelia of the cochlea, the urticule and the saccule as gestational age progresses. TrkB and TrkC expression intensified towards GW 12, at which point the BDNF mRNA localization was at its lowest. TrkA expression was limited to fiber subpopulations of the facial nerve at GW 10. In the adult human inner ear, we observed BDNF mRNA expression in the apical poles of the cochlear hair cells and supporting cells, while in the adult human utricle, the expression was localized in the vestibular hair cells. We demonstrate the highly specific staining patterns of BDNF mRNA and its putative receptors over a developmental period in which multiple hearing disorders are manifested. Our findings suggest that BDNF and neurotrophin receptors are important players during early human inner ear development. In particular, they seem to be important for the survival of the afferent sensory neurons.

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Expression of BDNF and TrkB mRNAs in the crista neurosensory epithelium and vestibular ganglia following ototoxic damage

Cited by 16 publications

References 47 publications

Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge

Changes in transient receptor potential cation channel superfamily V (TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin challenge

Role of neurotrophin in the taste system following gustatory nerve injury

Role of BDNF and neurotrophic receptors in human inner ear development

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