Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts

Abstract

The absence of bcl-2 expression in normal and diseased glomeruli suggests and supports the reported notion that the mechanism of apoptosis may be available in the injured glomerulus. Moreover, bcl-2 expression in podocytes near intraglomerular fibrotic lesions and in epithelial cells of early adhesions and cellular crescents indicates the deregulation of apoptosis and its possible role in the progression of glomerular scarring. Key words: apoptosis; bcl-2 oncoprotein; glomerulonephritis; immunohistochemical; renal rejection.

Immunosuppressant drug tacrolimus induced mitochondrial nephrotoxicity, modified PCNA and Bcl-2 expression attenuated by Ocimum basilicum L. in CD1 mice

“…6 ). The pattern of Bcl-2 expression in normal and diseased glomeruli suggests and supports the reported notion that the mechanism of apoptosis may be increased in the injured glomerulus [ 46 ].…”

Expression of Apoptosis‐Related Proteins Bcl‐2 and Bax Along with Transforming Growth Factor (TGF‐β1) in the Kidney of Patients with Glomerulonephritides

“…[21] Changes of bcl-2 and bax expression have been described in various experimental models [22,23] and human glomerulonephritis. [12,16] In this study, a significantly higher bcl-2 and bax expression was identified in the renal tissue of patients with GN compared to the controls. Bcl-2 and bax proteins were mainly localized within tubular epithelial cells, in the renal interstitium and to a lesser extent in the glomeruli.…”

Expression of apoptotic regulatory molecules in renal cell carcinoma: Elevated expression of Fas ligand

“…In the case of bcl‐2 expression, bcl‐2 transcripts were well represented in the majority of normal kidney samples but were extremely low or undetectable in several RCC. The expression of bcl‐2 has previously been examined in normal kidney and RCC by immunohistochemical analysis; 34 , 35 , 48 , 49 bcl‐2 was found to be consistently expressed in normal kidney localized mainly to the renal distal tubular and glomerular parietal epithelial cells 34 , 35 , 48 , 49 . However, a more variable expression of bcl‐2 was observed in RCC, 34 , 35 and appeared to relate to the tumour type in that tubulopapillary carcinomas strongly expressed bcl‐2 whereas only a few, or no bcl‐2‐positive cells, were observed in clear cell carcinomas 34 .…”