Expression of bcl-2 oncogene in gastric precancerous lesions and its correlation with syndromes in traditional Chinese medicine

Abstract

Apoptosis-associated bcl-2 oncogene is abnormally expressed in GPL, which correlates with different accompanying syndromes in TCM.

A hagyományos kínai fitoterápia értelmezése és beillesztése a nyugati típusú orvoslásba az emberi genom ismeretének birtokában

“…Az utóbbi években azonban sok növényi eredetű hatóanyagról bizonyították be, hogy különböző hatást fejtenek ki a génkifejeződésekre vagy a fehérjeaktivitásokra, ezért sürgetővé vált az irodalmi források szisztematikus feltárása annak érdekében, hogy még hatékonyabban kihasználhassák a gyógyítási lehetőségeket [11][12][13][14].…”

TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining

“…The practice of TCM involves physical therapy such as acupuncture and chemical therapy using materials originating from plants, minerals and animals, while TCM natural products may comprise one or more herbs in the form of decoctions [ 1 , 3 ]. In recent years, many herbal medicines have been reported to be associated with various symptoms or diseases and may exhibit a variety of effects through regulating a wide range of gene expressions or protein activities, such as the anti-tumor effects through the induction of the DR3 and DR4/5 death receptors in human monocytic leukemia cells [ 4 ], the anti-inflammatory potential through the inhibition of cytokine, iNOS and COX-2 expression via the NF-kappaB pathway [ 5 ], the hepatoprotective effect through the activation of pregnane X receptor in rats [ 6 ], the expression of bcl-2 oncogene in gastric precancerous lesions [ 7 ], the up-regulation of proapoptotic Bax expression in human bladder carcinoma T24 cells [ 8 ], the anti-aging effect on the cerebral gene expression levels in the senescence-accelerated mouse prone 8/Ta [ 9 ], and the alteration of gene expressions of hepatic stellate cells against hepatic fibrosis [ 10 ]. Therefore, studies about the connections between the TCMs, genes and diseases are emerging and important.…”