Expression of bcl-2 in Papillary Thyroid Cancers and its Prognostic Value

Aksoy, Murat; Giles, Yasemin; Kapran, Yersu; Terzioğlu, Tarık; Tezelman, Serdar

doi:10.1080/00015458.2005.11679794

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…In univariate analyses, Bcl‐2 positivity (p = 0.016) and EMA negativity (p = 0.036) in DSVPC were associated with shorter disease‐free survival, but there was no significance in multivariate analyses. A previous study has reported that Bcl‐2 expression in PTC has no association with the clinical prognosis (28), but there is one report stating that all PTCs with MACIS (Metastases, Age, Completeness of Resection, Invasion, Size) score higher than 6 show Bcl‐2 expression (29). In addition, Bcl‐2 expression in follicular carcinoma is associated with poor prognosis (30) and therefore, studied results on the significance of Bcl‐2 expression are yet truly variable.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical characteristics of diffuse sclerosing variant of papillary carcinoma: comparison with conventional papillary carcinoma

Koo

Shin

Hong

2010

APMIS

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Diffuse sclerosing variant of papillary carcinoma (DSVPC) is a rare variant of papillary thyroid carcinoma (PTC). It shows different clinicopathologic features to the conventional PTC, but the immunohistochemical characteristics of DSVPC are yet to be more clearly defined. The purpose of this study was to investigate the immunohistochemical features of DSVPC, which are different from those of PTC. Tissue microarray was constructed from the paraffin-embedded tissue of 49 DSVPC and 50 conventional PTC samples. Immunohistochemical stains for p63, p53, galectin-3, cytokeratin 19, β-catenin, Bcl-2, EMA, E-cadherin, CD15, and CD56 were performed on each tissue microarray. Immunohistochemical stain for p63 was negative in all conventional PTCs, but 14 (28.6%) cases of DSVPC showed p63 expression (p = 0.000). p53 was expressed in 38 (76.0%) cases of conventional PTC and 21 (42.9%) cases of DSVPC (p = 0.001). Galectin-3 was expressed in all 50 cases of conventional PTC, but eight (16.3%) cases of DSVPC did not express galectin-3 (p = 0.003). EMA was expressed more in DSVPC (40.8%) than in conventional PTC (20.0%, p = 0.024). In univariate analyses, Bcl-2 positivity (p = 0.016) and EMA negativity (p = 0.036) in DSVPC were associated with shorter time interval to tumor recurrence, but there was no significance for the two in multivariate analyses. DSVPC, a rare variant of PTC, has different immunohistochemical features from the conventional PTC, showing higher expression rate of p63 and lower expression rate of p53. It also shows galectin-3 negativity and EMA positivity.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical characteristics of diffuse sclerosing variant of papillary carcinoma: comparison with conventional papillary carcinoma

Koo

Shin

Hong

2010

APMIS

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“…In previous reports, Bcl-2 was found to be expressed in normal thyroid tissue and in well differentiated thyroid carcinomas (Moore et al , 1988; Pilotti et al , 1994; Pollina et al , 1996; Mitselou et al , 2004; Aksoy et al , 2005; Cvejic et al , 2008; Xu et al , 2007, 2008), but its expression was reported to decrease with dedifferentiation and aggressiveness (Moore et al , 1988; Pollina et al , 1996; Saltman et al , 2006). …”

Section: Discussionmentioning

confidence: 91%

Changes in the balance between proliferation and apoptosis during the progression of malignancy in thyroid tumours

et al. 2009

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The aim of this study was to gain better insight into molecular changes which reflect disturbances in the balance between proliferation and apoptosis during progression of thyroid malignancy from papillary microcarcinoma (PMC) via clinically manifest papillary carcinoma (PTC) to anaplastic carcinoma (ATC). The apoptosis related molecules (Bcl-2, Bax) and proliferation related marker (PCNA) were analysed immunohistochemically in 120 archival cases comprising PMC (n=34), PTC (n=52) and ATC (n=34). In addition, in situ apoptotic cell death was analysed by the TUNEL method. The average Bcl-2 staining score did not differ between PMC and PTC (p>0.05), but was significantly lower in ATC (p<0.05).The Bax score was higher in PTCs and ATCs than in PMCs (p<0.05). Due to these changes, the Bcl-2/Bax ratio showed a marked decrease from PMC to ATC (p<0.05), while proliferation activity increased significantly from PTC to ATC (p<0.05). Despite high Bax expression, the rate of apoptotic cell death was low in the investigated carcinomas, especially in ATC, i.e. the increase in proliferative activity was not counterbalanced with appropriate cell death. Differences were found in the expression of apoptotic molecules (Bcl-2 and Bax), their ratio (Bcl-2 /Bax) and in the rate of apoptotic cell death and proliferative activity between PMC, PTC and ATC, indicating that disturbances in the balance between apoptosis and proliferation, in favour of the latter, occur gradually during the progression of malignancy in thyroid tumours.

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“…Previous study has reported that BCL2 was found to be highly expressed only in poorly differentiated tumors [27]. Moreover, another study also showed that a lower expression level of BCL2 could act as an early sign of oncogenesis and be a reason for the favorable prognosis [28], suggesting that BCL2 may act as a protective factor in thyroid cancer. As for ITPR1, one study demonstrated that up-expression of ITPR1 shelters renal cancer cells against natural killer cells [29].…”

Section: Discussionmentioning

confidence: 94%

Development of A Three-Gene Signature Prediction Model for Lymph Node Metastasis in Papillary Thyroid Cancer

Huang

Liu

et al. 2020

Preprint

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Background: Thyroid cancer is one of the most prevalent endocrine cancers with a rising incidence rate over the past years. Papillary thyroid cancer (PTC) is the dominant historical type of thyroid cancer. Early lymph node metastasis happens frequently in PTC. However, some of the lymph node metastasis may be troublesome for detecting because of limited methods.Methods: Robust rank aggregation afforded us the shared differential expression genes among multiple datasets. Gene ontology analysis was performed to identify potential functions. Weighted gene co-expression network analysis was used to research the correlations between gene expression patterns with clinical characteristic. Protein-protein interaction network was performed to identify the hub genes. The least absolute shrinkage and selection operator and Logistic regression were performed to construct a prediction model.Results: We developed a three-gene signature prediction model for lymph node metastasis in PTC through transcriptomic analysis. After quality control, we collected 8 microarray datasets from GEO database and an RNA sequencing dataset from TCGA database. We found the transcriptome profiles were correlated with lymph node metastasis and 3 genes were verified to be independent prediction factors towards those statistic approach. Afterwards, we designed a predicable risk score system and effectively confirmed the model in two independent papillary thyroid cancer cohorts.Conclusions: We recommended a successful predicable model of lymph node metastasis in papillary thyroid cancer patients with moderate accuracy.

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Expression of bcl-2 in Papillary Thyroid Cancers and its Prognostic Value

Abstract: The rate of bcl-2 expression in microcarcinomas of papillary thyroid cancer decreases when compared to normal thyroid tissue. This may be an early sign of oncogenesis, and a reason for the favourable prognosis in microcarcinomas. However, bcl-2 cannot be used as a prognostic marker.

Cited by 17 publications

References 26 publications

Immunohistochemical characteristics of diffuse sclerosing variant of papillary carcinoma: comparison with conventional papillary carcinoma

Immunohistochemical characteristics of diffuse sclerosing variant of papillary carcinoma: comparison with conventional papillary carcinoma

Changes in the balance between proliferation and apoptosis during the progression of malignancy in thyroid tumours

Development of A Three-Gene Signature Prediction Model for Lymph Node Metastasis in Papillary Thyroid Cancer

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