Expression of Bcl-2, Bcl-XL, Bax and Apoptotic Index in Canine Mammary Tumours: Correlation with Clinicopathological Factlors

Yıldırım, Funda; Sönmez, Kıvılcım; Özyoğurtçu, Hande; Şennazlı, Gülbin; Gürel, Aydın; Gündüz, Mehmet; Sontas, H.B.

doi:10.1016/j.jcpa.2013.11.045

Cited by 2 publications

(2 citation statements)

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“…Ao comparar as porcentagens de marcação de ambas proteínas, pode-se observar ainda, níveis baixos de desregulação nas amostras avaliadas e provindas de carcinoma túbulo-papilar corroborando a ideia de que a desregulação de membros da família BCL-2 contribui com o desenvolvimento tumoral. Yildimirim et al (2014) apresentaram em seus resultados, uma alta presença de Bcl-2 em neoplasias mamárias caninas corroborando a presente pesquisa, onde a marcação da proteína Bcl-XL comportouse com expressão categorizada como positiva em sua maioria (Tabela 1).…”

Section: Discussionunclassified

Expressão De Bax E BCL-Xl Em Carcinoma Túbulo-Papilar De Cadelas

de Almeida Angelos,

Gonçalves Guimarães,

Pereira Bastos

et al. 2023

Anais Do XXVII INIC, XXIII EPG, XVII INIC Jr, XIII INID, III ENEXUN

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Section: Discussionunclassified

Expressão De Bax E BCL-Xl Em Carcinoma Túbulo-Papilar De Cadelas

de Almeida Angelos,

Gonçalves Guimarães,

Pereira Bastos

et al. 2023

Anais Do XXVII INIC, XXIII EPG, XVII INIC Jr, XIII INID, III ENEXUN

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“…In dogs, the developmental risk of malignant mammary tumours throughout life time ranges between 2-20% and this value is 2-5 times greater than the benign mammary tumours [2] . The prognosis of canine mammary tumours, their histopathology and proliferative activity have been intensively studied [3][4][5][6] . Intracellular steroid-hormone receptor proteins, primarily Estrogen Receptor (ER) and Progesterone Receptor (PR) have been studied both as indicators of prognosis and as guides to hormone and endocrine therapy [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Köpek Meme Tümörlerinde Östrojen Reseptör, Progesteron Reseptör ve Ki-67 Antikor İşaretlenmelerinin İmmunopatolojik Olarak Araştırılması

Şennazlı¹,

Yıldırım²,

Sönmez³

et al. 2015

Kafkas Univ Vet Fak Derg

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This study evaluates the expressions of Estrogen Receptor (ER), Progesterone Receptor (PR) and Ki-67 antibodies in canine mammary tumours and their prognostic values in regard to their histomorphologic subtypes. For this purpose, 60 tissue samples suspected as canine mammary tumour were examined and classified according to World Health Organisation's (WHO) criteria. Samples were labelled with anti ER, PR and Ki-67 using immunohistochemistry while ER, and PR values were showed significantly higher in benign tumours (P<0.001, P<0.001, respectively), contraversely Ki-67 value was significantly greater in malignant tumours (P<0.001). The statistical difference between malignant tumour types according to ER, PR and Ki-67 expressions were significant (P<0.001, P<0.01, P<0.001, respectively). Among malignant tumours, solid carcinomas and spindle cell carcinomas had the highest Ki-67 and lowest ER and PR expressions, complex adenocarcinomas and carsinosarcomas had the lowest Ki-67 and highest ER and PR expressions. It is concluded that presentation of immunohistochemical expression of differences between ER, PR and Ki-67 in canine mammary tumours, will provide contribution to the evaluation of tumours and determination of treatment processes in veterinary clinical pathology.

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Expression of Bcl-2, Bcl-XL, Bax and Apoptotic Index in Canine Mammary Tumours: Correlation with Clinicopathological Factlors

Cited by 2 publications

References 0 publications

Expressão De Bax E BCL-Xl Em Carcinoma Túbulo-Papilar De Cadelas

Expressão De Bax E BCL-Xl Em Carcinoma Túbulo-Papilar De Cadelas

Köpek Meme Tümörlerinde Östrojen Reseptör, Progesteron Reseptör ve Ki-67 Antikor İşaretlenmelerinin İmmunopatolojik Olarak Araştırılması

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