Expression of basement membrane components in odontogenic cysts

Poomsawat, Sopee; Punyasingh, Jirapa; Weerapradist, W

doi:10.1111/j.1601-0825.2005.01193.x

Cited by 22 publications

(27 citation statements)

References 36 publications

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“…15 Many extracellular matrix substrates for matrilysins are epithelial and vascular basement membrane components, such as, laminin, fibronectin, and type IV collagen. 2,12,35 Thus, the immunoreactivity of the SOKC and NSOKC epithelial cells to MMPs-7 and Ϫ26 observed in this research corroborate the results reported by other studies that analyzed basement membrane composition in the OKC epithelial-connective tissue junction.…”

Section: Table II Immunoreactivity To Matrix Metalloproteinases In Osupporting

confidence: 90%

“…This finding led the authors to suggest that type IV collagen discontinuity, together with altered expression of other extracellular molecules in the OKC epithelial basement membrane could be involved in the aggressive biological behavior of this lesion. The presence of matrilysins in the SOKC and NSOKC epithelial component observed in our study may account for the weak and discontinuous pattern of type IV collagen expression along OKC epithelial basement membranes, as reported by Oliveira et al 2 and Poomsawat et al 35 Despite the absence of statistical differences (P Ͼ .05) in epithelial immunoreactivity to MMPs-7 and Ϫ26 between SOKCs and NSOKCs, our results showed a tendency for a more consistent expression of these proteases in SOKCs. Comparing the samples, 100% of the SOKC cases showed epithelial immunoreactivity to MMPs-7 and Ϫ26, whereas only 75% and 80% of NSOKC cases had epithelial immunohistochemical expression of matrilysins 1 and 2, respectively.…”

Section: Table II Immunoreactivity To Matrix Metalloproteinases In Osupporting

confidence: 67%

“…Oliveira et al 2 and Poomsawat et al 35 verified a weak and discontinuous immunoreactivity to type IV collagen in the OKC epithelial basement membrane, when compared to other odontogenic cysts, such as radicular and dentigerous cysts. This finding led the authors to suggest that type IV collagen discontinuity, together with altered expression of other extracellular molecules in the OKC epithelial basement membrane could be involved in the aggressive biological behavior of this lesion.…”

Section: Table II Immunoreactivity To Matrix Metalloproteinases In Omentioning

confidence: 94%

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Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts

Cavalcante

Pereira

Nonaka

et al. 2008

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P Ͻ .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P Ͼ .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P Ͼ .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P Ͼ .05). Conclusion. MMPs-1, Ϫ7 and Ϫ26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.

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Section: Table II Immunoreactivity To Matrix Metalloproteinases In Osupporting

confidence: 90%

Section: Table II Immunoreactivity To Matrix Metalloproteinases In Osupporting

confidence: 67%

Section: Table II Immunoreactivity To Matrix Metalloproteinases In Omentioning

confidence: 94%

See 1 more Smart Citation

Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts

Cavalcante

Pereira

Nonaka

et al. 2008

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…ECM proteins have been detected in several odontogenic cysts and tumors, 7,8,[17][18][19] but no investigation has explored the relationship between collagen IV, MMPs, and TIMPs in odontogenic cysts and tumors.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is possible that this BM irregularity shown by KOTs favors the constant shedding of epithelial cells from the capsule and may be related to the higher recurrence rates of these tumors. Although consensus exists regarding the relationship between BM integrity and aggressiveness of the lesion, Poomsawat et al 19 found no association between the expression of BM components (laminin 1 and 5, collagen IV, and fibronectin) in RCs, DCs, and KOTs and the biologic behavior of these lesions. Therefore, in view of the functions of the BM, especially its involvement in the control of cell proliferation, differentiation, and invasion, it is evident how much these processes are altered in KOTs and ameloblastomas, a fact that can explain the more aggressive behavior of these tumors compared with RCs and DCs.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors

Henriques

Vasconcelos

Galvão

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. The aim of this study was to evaluate the immunohistochemical expression of collagen IV, matrix metalloproteinase (MMP) 9 and tissue inhibitor of MMP (TIMP) 2 in dentigerous cysts (DCs), radicular cysts (RCs), keratocystic odontogenic tumors (KOTs), and ameloblastomas. Study design. Twenty cases of DCs, 20 RCs, 20 KOTs, and 20 ameloblastomas were selected and analyzed by immunohistochemistry. Results. Most DCs and RCs showed continuous and Ͼ50% staining for collagen IV in the basement membrane of the epithelium, whereas predominantly discontinuous thin and Յ50% staining was observed in KOTs and ameloblastomas, with a significant difference in staining percentage (P Ͻ .001). MMP-9 was diffusely distributed and localized in both epithelial and mesenchymal cells of all of the lesions analyzed. The staining percentage was higher in the epithelium (P ϭ .058) and mesenchyme (P ϭ .005) of KOTs and ameloblastomas. Moreover, the distribution pattern, location, and percentage of expression of TIMP-2 were similar in the lesions studied, except for ameloblastoma, with a significant difference in staining percentage (P Ͻ .001).Conclusion. These results demonstrate that the interaction between collagen IV, MMP-9, and TIMP-2 is an important factor for the establishment of differences in the biologic behavior of the odontogenic cysts and tumors studied. Factors related to the epithelial and mesenchymal components participate in the regulation of the growth of odontogenic cystic lesions and tumors. 1 The altered expression of specific proteins of the extracellular matrix (ECM), associated with the exuberant presence of matrix metalloproteinases (MMPs) and the absence of expression of metalloproteinase inhibitors (TIMPs), may influence the behavior of these lesions. In the case of tumors, this situation contributes to the growth and higher aggressiveness of the tumor. 2 The odontogenic keratocyst, recently reclassified as keratocystic odontogenic tumor (KOT), 3 is known for its aggressive nature and high rate of recurrence, especially compared with other odontogenic cysts. 4 Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor with a marked invasion potential that results in multiple recurrences after enucleation and curettage. 5 In contrast, dentigerous (DC) and radicular (RC) cysts show an indolent behavior and rarely recur after surgical removal. KOT presents a cystic structure similar to that of DC and RC, but its invasive and destructive growth is similar to that of ameloblastoma. 6 KOT, ameloblastoma, DC, and RC show distinct evolutions and biologic behaviors. In view of this fact, a growing number of studies have tried to identify

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2022

Shear's Cysts of the Oral and Maxillofacial Regions

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Expression of basement membrane components in odontogenic cysts

Abstract: Substantial differences in the expression of BMCs among studied cysts were not observed, suggesting that the separation of the epithelial lining in OKCs is not associated with the existence of these proteins.

Cited by 22 publications

References 36 publications

Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts

Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts

Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors

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