Expression of aquaporin 9 in human chorioamniotic membranes and placenta

Wang, Shengbiao; Chen, Jiexiong; Beall, Marie H.; Zhou, Weidong; Ross, Michael G.

doi:10.1016/j.ajog.2004.05.089

Cited by 45 publications

(35 citation statements)

References 18 publications

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“…In these original reports, AQP9 mRNA expression was found in a few tissues, most notably liver and leukocytes in humans (Ishibashi et al 1998;Tsukaguchi et al 1999), as well as liver and immature sperm in mice (Tsukaguchi et al 1998). Since then, AQP9 immunoreactivity has been found in many tissues, including rat and human epididymis (Elkjaer et al 2000;Pastor-Soler et al 2001), various cell types of rodent and primate brain (Elkjaer et al 2000;Badaut et al 2001;Badaut et al 2004;Amiry-Moghaddam et al 2005;Arcienega et al 2010), mouse spinal cord (Oshio et al 2004), human chorioamnion and placenta (Damiano et al 2001;Wang et al 2004), mouse and human inner ear (Huang et al 2002;Degerman et al 2011), mouse and human small intestine (Okada et al 2003), rat and human prostate (Wang et al 2008;Hwang et al 2012), human skeletal muscle (Inoue et al 2009), urothelium (Rubenwolf et al 2009), rat and porcine oviduct (Skowronski et al 2009), human adipose tissue (Rodriguez et al 2011), human retina (Tran et al 2013;Yang et al 2013), and mouse and human skin (Sugiyama et al 2014). …”

Section: Introductionmentioning

confidence: 99%

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues

Lindskog

Asplund

Catrina

et al. 2016

J Histochem Cytochem.

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SummaryAQP9 is known to facilitate hepatocyte glycerol uptake. Murine AQP9 protein expression has been verified in liver, skin, epididymis, epidermis and neuronal cells using knockout mice. Further expression sites have been reported in humans. We aimed to verify AQP9 expression in a large set of human normal organs, different cancer types, rheumatoid arthritis synovial biopsies as well as in cell lines and primary cells. Combining standardized immunohistochemistry with high-throughput mRNA sequencing, we found that AQP9 expression in normal tissues was limited, with high membranous expression only in hepatocytes. In cancer tissues, AQP9 expression was mainly found in hepatocellular carcinomas, suggesting no general contribution of AQP9 to carcinogenesis. AQP9 expression in a subset of rheumatoid arthritis synovial tissue samples was affected by Humira, thereby supporting a suggested role of TNFα in AQP9 regulation in this disease. Among cell lines and primary cells, LP-1 myeloma cells expressed high levels of AQP9, whereas low expression was observed in a few other lymphoid cell lines. AQP9 mRNA and protein expression was absent in HepG2 hepatocellular carcinoma cells. Overall, AQP9 expression in human tissues appears to be more selective than in mice. (J Histochem Cytochem 64:287-300, 2016)

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Section: Introductionmentioning

confidence: 99%

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues

Lindskog

Asplund

Catrina

et al. 2016

J Histochem Cytochem.

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“…To date 13 aquaporins (AQPs) have been identified in mammals , and they play a critical role in controlling water flow particularly in specialized fluid-conducting organs such as kidney, lachrymal glands, lung and fetal membranes (Wintour, 1998;Liu et al, 2000, Ross andBrace, 2001;Magann et al, 2003). AQP gene expression has been seen in both placenta and fetal membranes across a diversity of species (Hasegawa et al, 1994;Ma et al, 1997;Johnston et al, 2000;Damiano et al, 2001;Wang et al, 2001;Mann et al, 2002;Wang et al, 2004;Liu et al, 2004;Wang et al, 2006); however their role in placental-amniotic-fetal water homeostasis has not been fully defined.…”

Section: Introductionmentioning

confidence: 99%

AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

et al. 2008

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“…Transcellular movement of water and solutes across the membranes during pregnancy, the intramembranous pathway, is a major pathway of fluid transport, in which aquaporin channels play a primary role [10]. Of the 13 currently recognized aquaporin water channels, aquaporins 1, 3, 8, and 9 have all been identified within the human placental unit [36,[57][58][59]. Wang et al [36] performed a series of in vitro studies demonstrating aquaporin 9 mRNA expression in human amnion, chorion, and placenta.…”

Section: Normal Pregnancy and Aquaporinmentioning

confidence: 99%

“…Of the 13 currently recognized aquaporin water channels, aquaporins 1, 3, 8, and 9 have all been identified within the human placental unit [36,[57][58][59]. Wang et al [36] performed a series of in vitro studies demonstrating aquaporin 9 mRNA expression in human amnion, chorion, and placenta. Of interest, no expression was noted in umbilical cord.…”

Section: Normal Pregnancy and Aquaporinmentioning

confidence: 99%

“…These findings support the role of aquaporin 9 in metabolism. Aquaporin 9 expression has been reported in human organs and cells including the liver [31], brain [32], testis [33], osteoclast cells [34], placenta [35], peripheral leukocytes [31], and has been localized in human chorioamniotic membranes [36]. Given the significant role of this aquaglyceroporin in solute transport, aquaporin 9 may be involved both in the maintenance of amniotic fluid composition, as well as in the supply of precursor substrates for cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

Mittal¹,

Romero²,

Mazaki‐Tovi³

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective. Aquaporin 9 (AQP9) is a water channel protein characterized by its high permeability to nutrients such as lactate and glycerol, as well as urea and other small solutes. These unique properties of AQP9 suggest that this molecule may play a role in the modulation of nutrient flux through the fetal membranes in conditions associated with increased metabolic demand, such as spontaneous labor and inflammation. The objective of this study was to determine the expression of AQP9 in the chorioamniotic membranes from women with and without term labor, as well as those with preterm prelabor rupture of membranes (PPROM) with and without histologic chorioamnionitis. Study design. A cross-sectional study was performed which included patients in the following groups: (1) term not in labor (TNL; n ¼ 14); (2) term, spontaneous labor (n ¼ 14); and (3) PPROM with (n ¼ 20) and without (n ¼ 17) histologic chorioamnionitis. AQP9 mRNA expression in fetal membranes was quantified using quantitative real-time reverse transcription-polymerase chain reaction and analyzed with a linear model including gestational age as a covariate. Results. (1) AQP9 mRNA expression was identified in all chorioamniotic membrane specimens; (2) AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with TNL (fold change 3.6; p ¼ 0.01); and (3) Among patients with PPROM, the presence of histologic chorioamnionitis was associated with a higher expression of AQP9 in the chorioamniotic membranes compared with those from women without histologic chorioamnionitis (fold change 8.7; p 5 0.001). Conclusion. Aquaporin 9 mRNA expression is higher in the fetal membranes from patients with spontaneous term labor and those with PPROM and histologic chorioamnionitis. These findings are novel, and suggest a role for aquaporin 9 in membrane-mediated transfer of nutrients to support the increased metabolic demands associated with the host immune response of the terminal pathway of parturition and histologic chorioamnionitis.

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Expression of aquaporin 9 in human chorioamniotic membranes and placenta

Cited by 45 publications

References 18 publications

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues

AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

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