Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance

Wang, Wei; Li, Qing; Yang, Tao; Bai, Guang; Li, Dongsheng; Li, Qiang; Sun, Hongzhi

doi:10.1186/1477-7819-10-242

Cited by 51 publications

(42 citation statements)

References 15 publications

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“…Huang et al (18) also verified that AQP5 promotes the proliferation and migration of human gastric carcinoma cells. Wang et al (19) performed a study to show that AQP5 was mainly expressed in colorectal carcinoma cells and barely expressed in paraneoplastic normal tissues. The clinical significance of AQP5 in colorectal carcinoma is unknown.…”

Section: Discussionmentioning

confidence: 99%

AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer

Shan

Cui

et al. 2014

Oncology Reports

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Abstract. The aquaporins (AQPs) are water channel proteins that exhibit several properties related to tumor development. However, the expression and clinical significance of AQP5 in colorectal cancer, particularly the correlation with circulating tumor cells (CTCs), has not been elucidated. The aim of the present study was to determine whether or not the expression of AQP5 is a strong prognostic biomarker for colorectal cancer. The results showed that of 45 tumor specimens, 14 (31.1%) had high levels of expression of AQP5, 29 (64.4%) exhibited a moderate (intermediate) level of staining, and 2 (4.4%) had an absence of AQP5 staining. AQP5 was only occasionally detected in para-neoplastic [3/45 (6.67%)] and normal tissues [3/45 (6.67%)]. AQP5 protein overexpression frequently accompanied gene amplification detection with fluorescence in situ hybridization (FISH). Moreover, AQP5 expression in colorectal cancer cells was upregulated compared to normal colon cells. AQP5 overexpression was also associated with TNM stage (P=0.002), lymph node metastasis (P=0.016), and distant metastasis (P=0.000). The relationships between age, gender, histologic grade and tumor size with expression of AQP5 were not significant (P>0.05). A positive correlation between the number of CTCs and AQP5 expression (P<0.05) was demonstrated. In addition, patients who did not express AQP5 had a superior cumulative survival rate compared to patients with AQP5 positivity. AQP5 may be used as a novel biomarker for colorectal cancer aggressiveness and metastasis, but it does not reflect drug resistance.

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Section: Discussionmentioning

confidence: 99%

AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer

Shan

Cui

et al. 2014

Oncology Reports

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“…Previous studies have established that tumor growth, development, invasion and metastasis depend upon sufficient nutrient supply and metabolism, and that water molecules are important in the modulation of the tumor microenvironment and metabolism (9,10). Increasing evidence has demonstrated that aquaporins (AQPs), a family of small transmembrane proteins responsible for water transport, are involved in the incidence and progression of cancer (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Expression of aquaporin 5 in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer

Song¹,

Yang²,

et al. 2015

Oncology Letters

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Abstract. Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary and lymph node metastatic NSCLCs. An immunohistochemical labeled streptavidin-biotin method was used to determine the expression of AQP5 in 94 cases of NSCLC primary carcinoma, which included 51 cases accompanied by lymph node metastasis. The results revealed that the expression of AQP5 was significantly higher in adenocarcinomas compared with squamous cell carcinomas (P=0.002). In addition, the percentage of AQP5 expression in the primary carcinomas with lymph node metastasis was significantly higher compared with those without lymph node metastasis (P=0.024). However, no statistically significant difference in the percentage of AQP5 expression was observed between the metastatic and the primary carcinomas (P=0.377). The expression of AQP5 exhibited a correlation with the tumor-node-metastasis staging of NSCLC (P=0.027). The percentage of AQP5 expression in stage III and IV tumors was higher than that in stage I and II tumors. In addition, AQP5 expression was correlated with the survival rate of NSCLC patients (P=0.051). In conclusion, the results of the present study provide evidence for the AQP5-facilitated incidence, progression and metastasis of NSCLC.Therefore, AQP5 may be used as a potential target to investigate the incidence, progression and metastasis of NSCLC.

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“…But Jablonski et al (2007) reported that AQP8 expression down-regulated in mouse hepatocellular carcinoma model. AQP8 was mainly expressed in paraneoplastic normal tissues and barely expressed in colorectal carcinoma cells (Wang et al, 2012). These contradictory reports indicate the necessity of further research on effects of AQPs in tumorigenesis.…”

Section: Discussionmentioning

confidence: 98%

Increased Migration and Local Invasion Potential of SiHa Cervical Cancer Cells Expressing Aquaporin 8

Shi

Nijiati²,

Ma³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Overexpression of several aquaporins (AQPS) has been reported in different types of human cancer but roles in human carcinogenesis have yet to be clearly defined. Here, we up-regulated expression of the AQP8 gene in SiHa human cervical cancer cells with a lentivirus transfection system and investigated its effects as a potential therapeutic target for cervical cancer. Results showed AQP8 overexpression did not affect their substrate adherence and proliferation, but accelerated migration as assessed by transwell migration and wound healing assays. Moreover, AQP8 overexpression significantly enhanced local invasion of SiHa cells in nude mice. These findings altogether indicate that AQP8 overexpression increases migration of SiHa cells and probably participates in the process of tumor local invasion.

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Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance

Cited by 51 publications

References 15 publications

AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer

AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer

Expression of aquaporin 5 in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer

Increased Migration and Local Invasion Potential of SiHa Cervical Cancer Cells Expressing Aquaporin 8

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