Expression of apoptosis in human saphenous vein grafts in restoration of blood flow through coronary bypass surgery

Tirapelli, Luís Fernando; Tirapelli, Daniela Pretti da Cunha; Dalio, Marcelo Bellini; Rodrigues, Alfredo José; Évora, Paulo Roberto Barbosa

doi:10.1590/s0102-76382009000400009

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…The preoperative assessment of coronary vascular resistance was assessed and proved to be a significant predictor of success for coronary artery bypass surgery 21 . Intact segments of human saphenous veins submitted to distensions at different pressures were found to have similar apoptotic proteins expression when compared with non-distended control veins 22 . The use of topical application of epsilon aminocaproic acid was found to reduce postoperative bleeding in the first 24 hours and requirements of blood transfusion after coronary artery bypass graft surgery 23 .…”

Section: The Cardiovascular Systemmentioning

confidence: 92%

“…Cardiopulmonay bypass surgery. Per se, or in conjunction with arterial grafting, cardiopulmonary bypass surgery was the object of 13 papers [12][13][14][15][16][17][18][19][20][21][22][23][24] . The bypass procedure was found to alter propofol pharmacokinetics and bispectral index during coronary surgery with a resulting increase in the brain's elevated sensitivity to anesthetics 12 .…”

Section: The Cardiovascular Systemmentioning

confidence: 99%

See 1 more Smart Citation

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Patel¹,

Caramelli

Silva

2011

Revista da Associação Médica Brasileira

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Section: The Cardiovascular Systemmentioning

confidence: 92%

Section: The Cardiovascular Systemmentioning

confidence: 99%

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Patel¹,

Caramelli

Silva

2011

Revista da Associação Médica Brasileira

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“…Helito et al discussed quality of life in heart transplant candidates 41. Tirapelli et al described the occurrence of apoptosis in human saphenous vein grafts in the restoration of blood flow through coronary bypass surgery 42. Vieira et al analyzed the hydrodynamic profiles of different roller pumps models used for cardiopulmonary bypass 43…”

Section: Methodsmentioning

confidence: 99%

A review of cardiopulmonary research in Brazilian medical journals: clinical, surgical and epidemiological data

Serrano

Silva

2010

Clinics

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Research in the field of cardiopulmonary disease in Brazil has been very active in recent decades. The combination of PUBMED, SCieLO, open access and online searching has provided a significant increase in the visibility of Brazilian journals. This newly acquired international visibility has in turn resulted in the appearance of more original research reports in the Brazilian scientific press. This review is intended to highlight part of this work for the benefit of the readers of “Clinics.” We searched through PUBMED for noteworthy articles published in Brazilian medical journals included in the Journal of Citation Reports of the Institute of Scientific Information to better expose them to our readership. The following journals were examined: “Arquivos Brasileiros de Cardiologia,” “Arquivos Brasileiros de Endocrinologia e Metabologia,” “Brazilian Journal of Medical and Biological Reviews,” “Jornal Brasileiro de Pneumologia,” “Jornal de Pediatria,” “Revista Brasileira de Cirurgia Cardiovascular,” “Revista da Associação Médica Brasileira,” Revista da Escola de Enfermagem U.S.P.” and “São Paulo Medical Journal.” These journals publish original investigations in the field of cardiopulmonary disease. The search produced 71 references, which are briefly examined.

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“…21) This is due, in part, to the fact that distention of the SV with high intraluminal pressure induces functional and morphological alterations, which leads to early thrombosis and graft failure. 19,[21][22][23] Distention with high pressure is a routine part of surgical preparation of the SV for grafting in order to check for leaks and to increase the vascular diameter during perioperative and postoperative periods. During surgical preparation for grafting in individual hospitals, SV is distended with various degrees of pressure, which are sometimes very high.…”

Section: Effect Of the Distention With High Pressure On The Presence mentioning

confidence: 99%

Relative Contributions of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in 5-HT-Induced Vasoconstriction of the Distended Human Saphenous Vein as a Coronary Artery Bypass Graft

Nakamura

Tanaka

Kuwabara³

et al. 2011

Biological & Pharmaceutical Bulletin

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Coronary artery bypass graft (CABG) surgery has been performed for about 40 years. In 1967, the technique of saphenous vein (SV) bypass grafting was introduced, followed 1 year later by the use of internal thoracic artery (ITA).1) Whereas ITA is the first-choice arterial graft, 2,3) SV still continues to be the most commonly used conduit vessel for CABG 4,5) because of ready availability and suppleness. One of the most serious problems in CABG surgery is that the bypass grafts often go into spasm after implantation into coronary arterial circulation, which has led to premature occlusion and increased perioperative morbidity. 6,7) Among substances that can initiate severe vasoconstriction, 5-hydroxytryptamine (5-HT) has been identified as playing an important role in the pathogenesis of vascular spasm. [8][9][10][11][12][13] Although 5-HT 2A and/or 5-HT 1B/1D receptor subtypes almost exclusively mediate 5-HT-induced vasoconstriction, [8][9][10][11][12][13][14][15][16][17][18] the relative contributions of these receptor subtypes to vasoconstrictions are species-dependent and vascular beddependent. Therefore, the selection of the best pharmacological agent to prevent 5-HT-induced spasm of the bypass grafts used in CABG surgery requires better understanding of the contributions of 5-HT receptor subtypes to vasoconstriction in the clinically used human vessels.From the viewpoint mentioned above, we revealed that 5-HT-induced vasoconstriction is mediated equivalently via 5-HT 2A and 5-HT 1B receptors in the human ITA.18) In the human SV, Borton et al. 14) have reported that both 5-HT 1 and 5-HT 2 receptors are involved in vasoconstriction by using a 5-HT 2 receptor antagonist and a 5-HT 1 receptor agonist. However, the relative contributions of 5-HT receptor subtypes that mediate vasoconstriction caused by 5-HT in the human SV are still unclear.It has been established that, before implantation into the coronary arterial circulation, the segment of SV used as a vein graft is distended by applying high intraluminal pressures with injection of saline or a patient's heparinized blood to check for leaks and to increase the vascular diameter. This fact should be considered in experiments for evaluation of 5-HT receptor subtypes responsible for vascular functions because the distension may influence both contractile and dilatory responses of the SV. 19)The aim of the present study was to elucidate the relative contribution of 5-HT receptor subtypes mediating 5-HTinduced vasoconstriction of the distended human SV obtained from CABG surgery. We examined the effects of sarpogrelate and SB224289, antagonists of 5-HT 2A and 5-HT 1B receptors, respectively, on the 5-HT-induced vasoconstriction and also performed immunolabeling of the 5-HT 2A and 5-HT 1B receptors in the distended SV. MATERIALS AND METHODS Preparation of Blood Vessels and Contractile StudiesSegments of the human SV were harvested from patients (nϭ12) who were undergoing CABG surgery at Miyazaki Prefectural Nobeoka Hospital (Miyazaki, Japan). Once the vein was comp...

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Expression of apoptosis in human saphenous vein grafts in restoration of blood flow through coronary bypass surgery

Cited by 7 publications

References 11 publications

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

A review of cardiopulmonary research in Brazilian medical journals: clinical, surgical and epidemiological data

Relative Contributions of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in 5-HT-Induced Vasoconstriction of the Distended Human Saphenous Vein as a Coronary Artery Bypass Graft

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