Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma

Hong, Tao; Shimada, Yutaka; Uchida, Satoshi; Itami, Atsushi; Li, Zhigang; Ding, Yongzeng; Kaganoi, Junichi; Komoto, Izumi; Sakurai, Takaki; Imamura, Masayuki

doi:10.3892/ijmm.8.2.141

Cited by 29 publications

(40 citation statements)

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“…Technical conditions could also be discussed with the use of microwave heating for antigen retrieval instead of enzymatic predigestion of tissue sections. Despite these limitations, our results are reminiscent of those reported by Hong et al [19], who found no difference in CD31-based MVD between LM and LMS of the gastrointestinal tract.…”

Section: Discussioncontrasting

confidence: 40%

“…Although Hong et al [19] observed VEGF overexpression in LMS compared to LM, VEGF expression was not associated with a higher intratumoral MVD. In our study of uterine LMS, LM, and normal myometrial samples, we found no difference in VEGF expression according to the histologic type, and no relation between VEGF expression and MVD based on FvW, CD34 or CD31 immunostaining.…”

Section: Discussionmentioning

confidence: 96%

“…Discrepancies in MVD according to the marker and technique make it difficult to compare quantitative results of previous studies [15,27]. Little information is available about angiogenesis in sarcomas [7,18,19,31].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Poncelet¹,

Fauvet²,

Feldmann³

et al. 2004

Journal of Surgical Oncology

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 96%

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Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Poncelet¹,

Fauvet²,

Feldmann³

et al. 2004

Journal of Surgical Oncology

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“…One distinguishing difference between benign leiomyomas and some malignant leiomyosarcomas was the acquisition of a p53 mutation. Hong et al [10] stated that the frequency of p53 positivity was not as high as expected even though p53 expression in leiomyosarcoma was significantly higher than leiomyoma. In addition to their demonstration that p53 expression was seen in a significant proportion of uterine leiomyosarcomas, Jeffers et al [11] claimed that positive immunohistochemistry did not always correlate positively with the presence of mutation.…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Smooth Muscle Tumors Utilizing p53, pTEN and Ki-67 Expression with Estrogen and Progesterone Receptors

Gökaslan

Türkeri²,

Kavak³

et al. 2005

Gynecol Obstet Invest

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Background/Aim: To investigate the expression and value for diagnosis of the genes, p53 and pTEN, the protein, Ki-67, and the receptors, estrogen and progesterone, in differentiating smooth muscle tumors of the uterus. Material and Method: Seventeen samples of leiomyosarcoma, 2 smooth muscle tumors with uncertain malignant potential (STUMP), 9 atypical myomas and 15 leiomyomas were stained immunohistochemically. The χ² test was used for the statistical analysis of the data. Results: The malignant side of the spectrum was strongly stained for Ki-67 and p53 while uniformly decreasing toward the benign tumors. The results were found to be statistically significant (p < 0.0001). The staining for progesterone receptor was also statistically significant, but the tumors that were considered benign, such as leiomyoma and atypical myoma, were the ones strongly stained (p = 0.005). The expression of estrogen receptor was significant in these tumors, but the p value was very close to the cut-off value (p = 0.07). As the degree of differentiation of the tumor increased, the trend showed stronger staining for estrogen receptor. However, no difference was detected in the staining properties of the tumors for pTEN (p = 0.2457). Conclusion: The expression of Ki-67, p53 and progesterone receptors is promising in immunodifferentiation of smooth muscle tumors of the uterus with malignant potential.

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“…Experimentally, these tumors may be induced in rabbits by intramuscular deposition of nickel subsulphide [6]. Angiogenic factors, such as platelet-derived endothelial cell growth factor (PD-ECGF), vascular endothelial growth factor (VEGF) and TGF-·, may be involved in tumor angiogenesis, and the frequently high ratio of Bcl-2/Bax and expression of p53 gene mutation might be related to a chemoresistance mechanism [7].…”

Section: Discussionmentioning

confidence: 99%

Primary Jejunal Leiomyosarcoma Mimicking a Gynecologic Tumor

Cheng

Lee²,

Tsai

et al. 2002

Gynecol Obstet Invest

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Alimentary leiomyosarcoma (LMS) is not uncommon; however, LMS which metastasizes to the ovary and uterine serosa is extremely rare. We present a case diagnosed as LMS due to the negative finding on the CD117 stain, which is the most specific criterion for the differential diagnosis of gastrointestinal stromal tumor and LMS. Despite the daunting reoperation which was performed within a short interval in this case, the patient made a rapid recovery from both procedures.

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Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma

Cited by 29 publications

References 0 publications

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Differential Diagnosis of Smooth Muscle Tumors Utilizing p53, pTEN and Ki-67 Expression with Estrogen and Progesterone Receptors

Primary Jejunal Leiomyosarcoma Mimicking a Gynecologic Tumor

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