Expression of Androgen Receptor by Fibroepithelioma of Pinkus-Evidence Supporting Classification as a Basal Cell Carcinoma Variant

Katona, Terrence M.; Ravis, Scott M.; Moores, William B.; Billings, Steven D.

doi:10.1097/00000372-200606000-00021

Cited by 14 publications

(28 citation statements)

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“…30 Several studies have shown androgen receptor to be present in basal cell carcinoma but absent or rarely expressed in benign follicular tumors. 22,23,[30][31][32] ARnegative CK20-positive phenotype was suggested to be diagnostic of DTE as opposed to basal cell carcinoma, which is AR-positive CK20-negative. [22][23] Interestingly, fibroepithelioma of Pinkus has recently been shown to express AR and retain Merkel cells, suggesting its classification as a trichoblastic tumor intermediate between trichoblastoma and basal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

Shimanovich

Krahl²,

Rosé

2010

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

Shimanovich

Krahl²,

Rosé

2010

Journal of the American Academy of Dermatology

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“…Androgen receptor (AR) is conversely expressed both in BCC and FEP but just minimally in trichoblastomas. Katona et al (10) detected AR in 77 % of FEP and 73 % of BCC, in 17 % of trichoepitheliomas, and 0 % of trichoblastomas. Since AR expression is signifi cantly higher in FEP compared to benign follicular skin tumors, but not BCC, this supports its classifi cation as a variant of BCC.…”

Section: Resultsmentioning

confidence: 99%

“…However, these cells are found in signifi cantly higher number in both FEP and trichoblastoma compared to BCC (9). Katona et al (10) immunohistochemically identifi ed Merkel cells in 85 % of FEP, 73 % of benign follicular tumors, but only in 27 % of BCC. Since this feature is generally characteristic for benign neoplasms with follicular germinative differentiation but not for BCC, it may indicate relationship of FEP to the trichoblastoma rather than to the BCC.…”

Section: Resultsmentioning

confidence: 99%

Fibroepithelioma of Pinkus

Bartoš¹,

Pokorny²,

Zacharová³

et al. 2013

BLL

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Basal cell carcinoma (BCC) is recently the most common cancer in humans characterized by several histopathological subtypes. Fibroepithelioma of Pinkus (FEP) is traditionally classifi ed as a very rare variant of BCC, however, it manifests clinical and morphological differences that distinguish it from most other types BCCs. This study was performed to evaluate the incidence of FEP and clinical-pathological characteristics of patients diagnosed with this tumor. Four cases of primary FEP (3 females, 1 male, mean age 53.4 y) were analyzed retrospectively. The prevalence of FEP was 0.7 % of all diagnosed BCCs. Topographically, tumors were localized on the right brachium, right gluteal region, left mesogastrium, and right side of the abdomen. Histological examination showed typical anastomosing cords of basaloid cells extending from the overlying epidermis into the loose fi brous stroma in the dermis. Mitotic activity or signifi cant cellular atypia, as well as sign of solar dermatosis were absent. Mean horizontal and vertical diameter of the lesions were 7.7 and 2.8 mm, retrospectively. We did not observe infi ltration of deeper skin structures. All lesions were removed completely and classifi ed as pathological stage pT1. Three cases manifested typical picture of a "pure" FEP, one lesion had partially a feature of nodular type BCC, too. Although FEP is conventionally considered as indolent BCC variant with a favorable clinical outcome, recent evidences also favors its classifi cation as a form of trichoblastoma. This is appropriate example how some types of cutaneous tumors can overlap in terms of dignity and clinical-morphological characteristics. This should be taken into account in differential diagnosis and in predicting of biological behaviour of the individual tumors of the skin (Tab. 2, Fig. 3, Ref. 26). Full Text in PDF www.elis.sk.

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“…It is typically located to the trunk and extremities, most commonly on the lower back [10], and has a male to female ratio 1:1 [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…However, others consider it to be a variant of basal cell carcinoma [3,5,8,11,13]. Evidence supporting the malignant nature of FOP are extension of the tumor into the dermis and subcutaneous tissue, composition of trichoblasts, a fenestrated growth pattern, foci of clefts between the tumor strands and fibrotic stroma, expression of androgen receptor in FOP and in BCC but minimally in trichoblastoma [10] and finally the occurrence of FOP in continuity with a nodular basal cell carcinoma [10]. Our case supports the hypothesis of FOP being a variant of BCC as there is continuity of FOP with nodular BCC.…”

Section: Discussionmentioning

confidence: 99%

Fibroepithelioma of Pinkus in Continuity with Nodular Basal Cell Carcinoma: Supporting Evidence of the Malignant Nature of the Disease

Ioannidis

Papaemmanuil

Kakoutis

et al. 2010

Pathol. Oncol. Res.

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Basal cell carcinoma, the most common skin cancer, has several clinical and histopathological variants, with its most common form being nodular basal cell carcinoma. Fibroepithelioma of Pinkus is considered as an unusual variant of basal cell carcinoma by some authors while others consider it to be a benign analogue of basal cell carcinoma. We present a rare case of fibroepithelioma of Pinkus in continuity with a nodular basal cell carcinoma, a finding that supports the classification of fibroepithelioma of Pinkus as a variant of basal cell carcinoma.

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Expression of Androgen Receptor by Fibroepithelioma of Pinkus-Evidence Supporting Classification as a Basal Cell Carcinoma Variant

Cited by 14 publications

References 0 publications

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors

Fibroepithelioma of Pinkus

Fibroepithelioma of Pinkus in Continuity with Nodular Basal Cell Carcinoma: Supporting Evidence of the Malignant Nature of the Disease

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