Expression of Androgen-binding Protein (ABP) in Human Cardiac Myocytes

Schöck, Helena; Herbert, Z.; Sigusch, Holger H.; Figulla, H. R.; Jirikowski, Gustav F.; Lotze, Ulrich

doi:10.1055/s-2006-925331

Cited by 29 publications

(26 citation statements)

References 17 publications

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“…It should, however, be noted that cardiac myocytes are targets for androgens. 36 Dilated cardiomyopathy has previously been associated with low levels of testosterone in men, 37 and Schock et al 38 demonstrated increased SHBG in cardiomyocytes of men with dilated cardiomyopathy. This is in line with our data on a positive association of SHBG and the inverse association of FT levels with NT-pro-BNP.…”

Section: Discussionmentioning

confidence: 98%

Sex steroids and mortality in men referred for coronary angiography

Wehr

Pilz

Boehm

et al. 2010

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 98%

Sex steroids and mortality in men referred for coronary angiography

Wehr

Pilz

Boehm

et al. 2010

Clinical Endocrinology

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“…Treatment with DHEA prevents pulmonary vascular changes and RV hypertrophy, and prolongs survival in animal models of pulmonary hypertension (PH) (7,8). SHBG is expressed in myocytes of failing human hearts and in murine fetal lung epithelium, but its role in pulmonary vascular function has not been studied (9,10).…”

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confidence: 99%

Sex Hormones Are Associated with Right Ventricular Structure and Function

Ventetuolo¹,

Ouyang²,

Bluemke³

et al. 2011

Am J Respir Crit Care Med

157

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Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.Keywords: sex; sex hormones; right ventricle Sex differences in atherosclerosis and congestive heart failure (CHF) have been well described, with women experiencing a significant lag in the onset of coronary artery disease and lower rates of CHF compared with men (1). Estrogen, testosterone, dehydroepiandrosterone (DHEA), and sex hormone-binding globulin (SHBG) have important, albeit controversial, roles in left ventricular (LV) function and systemic vascular disease, whereas the effects of sex hormones on right ventricular (RV) and pulmonary vascular function are unknown.Estrogen has protective effects on the pulmonary vasculature and improves RV contractility in animals (2-4). Testosterone has been shown to be a pulmonary vasodilator, yet has unclear effects on pulmonary endothelium (5, 6). Treatment with DHEA prevents pulmonary vascular changes and RV hypertrophy, and prolongs survival in animal models of pulmonary hypertension (PH) (7,8). SHBG is expressed in myocytes of failing human hearts and in murine fetal lung epithelium, but its role in pulmonary vascular function has not been studied (9, 10).Despite the beneficial effects of estrogen on the pulmonary vasculature, female sex is the best established clinical risk factor for idiopathic pulmonary arterial hypertension (PAH) (11). Yet, women have higher RV ejection fraction (RVEF) and improved survival compared with men with PAH (12-14). In systemic cardiovascular disease, an individual's estrogen:testosterone balance may be more predictive of disease risk than either hormone alone (15,16). Last, it is unknown how sex hormones affect the interaction of the RV with the pulmonary vasculature, particularly in individuals with no known (or subclinical) PH.We examined the cross-sectional association of serum estradiol (E2), bioavailable testosterone (bioT), DHEA, SHBG, and the E2:testosterone ratio (E2:T) with RV structure and function assessed by cardiac magnetic resonance imaging (MRI) in a large AT A GLANCE COMMENTARY Scientific Knowledge on the SubjectFemale sex is a risk factor for the development of pulmonary hypertension (PH), yet women appear to have better right ventricular (RV) function and improved survival compared to men with PH....

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“…Autoradiographic and biochemical studies previously demonstrated that murine and primate atrial and ventricular cardiomyocytes express androgen receptors that may affect myocardial structure and function (Krieg et al ., ; McGill et al ., ). In addition, molecular studies detected androgen receptor and androgen‐binding protein RNA in murine and human hearts (Marsh et al ., ; Schock et al ., ). Testosterone exposure affected both the nuclear and cytoplasmic distribution of these receptors, suggesting they are physiologically functional and that testosterone may directly regulate cardiomyocyte function, growth and hypertrophic remodelling (Lin et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Sex steroids in relation to cardiac structure and function in men

2016

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The prevalence of testosterone substitution as well as of androgen deprivation therapy in men is increasing. This review aims to summarise available knowledge of the effects of sex steroids on cardiac structure and function in men. MEDLINE was searched through PubMed. Original studies, systematic reviews and meta-analyses, and relevant citations were screened. A short-term hormonal intervention study in healthy young men with respect to echocardiographic parameters of structure and function was performed. Preclinical research provides sufficient evidence for the heart as a substrate for sex hormones. In animals, administration of oestradiol appears to have beneficial effects on cardiac structure and function, whereas administration of testosterone to noncastrated animals adversely affects cardiac function. However, the effects of sex steroids on cardiac function and structure appear more heterogeneous in human observational studies while comparative, prospective studies in humans are lacking. It is concluded that although effects of testosterone substitution as well as of androgen deprivation on cardiac structure and function can be expected based on pre-clinical research, there exists an important knowledge gap of the effects of hormonal intervention in men. As such, there is a need to address this question in future prospective intervention trials.

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Expression of Androgen-binding Protein (ABP) in Human Cardiac Myocytes

Cited by 29 publications

References 17 publications

Sex steroids and mortality in men referred for coronary angiography

Sex steroids and mortality in men referred for coronary angiography

Sex Hormones Are Associated with Right Ventricular Structure and Function

Sex steroids in relation to cardiac structure and function in men

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