Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchus

Abstract

We conclude that expression of aminopeptidase N and dipeptidyl peptidase IV is restricted to specific sites within the human bronchus. Furthermore, in the bronchial epithelium of allergic asthmatics an increased number of aminopeptidase N-expressing dendritic cells and eosinophils can be found.

Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases

“…Lymphocytes were not attracted, and the enzyme activity of DP IV and APN was not affected; these results are in good correlation with those published for allergic asthmatic patients, where no differences in peptidase activities in serum or BALF have been observed between asthmatics and healthy non-smokers ( Van der Velden et al, 1998). Surprisingly, the inhibition of DP IV and APN led to a further increase in inflammation and IL-6 concentration in the lavage and tissue of animals treated with a combination of actinonin and LZNP.…”

“…FAP is expressed on activated fibroblasts, and its expression is correlated to the severity of liver fibrosis (Gorrell 2005;Levy et al, 2002). In the lung, DP IV, or DP IV homologue enzymes, and APN have been identified on macrophages, epithelial cells and fibroblasts (Juillerat-Jeanneret et al, 1997;Sedo et al, 1991;Van der Velden et al, 1998) and infiltrating lymphocytes (Wahlstrom et al, 1999).…”

Peptidases: structure, function and modulation of peptide‐mediated effects in the human lung

“…In the human lung, NEP is expressed by bronchial epithelial cells, submucosal glands, bronchial smooth muscle, and endothelium [6,7]. In addition, NEP can be found on alveolar epithelial cells.…”

Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis

“…Similar expression was noted in the human bronchus. 47 In vitro studies demonstrated that CD4 + memory T cells with the capacity for transendothelial migration express CD26 and CD25 and that CD26 is one likely candidate for control of T cell transmigration. 48 It is suggested that CD26 on blood vessels might be involved in the processing of intravascular peptides, such as substance P and in the regulation of substance P induced plasma leakage.…”

“…48 It is suggested that CD26 on blood vessels might be involved in the processing of intravascular peptides, such as substance P and in the regulation of substance P induced plasma leakage. 47 Recently, several studies demonstrated that CD26 can process several chemokines such as eotaxin, RANTES, and MDC. 23 49 50 After cleavage of eotaxin by CD26, its chemotactic potency for blood eosinophils and its signalling capacity through the CCR3 receptor were reduced.…”