Expression of adult and fetal natural killer cell markers in sinonasal lymphomas [see comments]

Suzumiya, Junji; Takeshita, Morishige; Kimura, N.; Kikuchi, Masahiro; Uchida, Taisuke; Hisano, Shusuke; Eura, Youichi; Kozuru, Mitsuo; Nomura, Yuko; Tomita, Keisuke

doi:10.1182/blood.v83.8.2255.bloodjournal8382255

Cited by 18 publications

(19 citation statements)

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“…Expression of CLA was examined in 52 NK lymphoma patients who were diagnosed at the Department of Pathology of Okayama University, the Aichi Cancer Center and Fukuoka University. Details of the clinicopathological features of 27 of the cases have been reported previously (Suzumiya et al, 1994(Suzumiya et al, , 2000Nakamura et al, 1995Nakamura et al, , 1997Miyamoto et al, 1998;Hirakawa et al, 1999). The diagnostic criteria for NK-cell lymphomas were as follows: medium-large nucleated lymphoma cells infiltrated diffusely and often with angiocentric, angiodestructive features and necrotic foci.…”

Section: Methodsmentioning

confidence: 99%

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal‐type natural killer‐cell lymphoma

et al. 2002

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Summary. Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA + group (n ¼ 29) had a much worse prognosis than the CLA -group (n ¼ 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.

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Section: Methodsmentioning

confidence: 99%

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal‐type natural killer‐cell lymphoma

et al. 2002

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“…In the new WHO classification, this disease is called extranodal NK/T-cell lymphoma, nasal type. It is called 'NK/T' rather than simply 'NK' because although most cases have genuine NK-cell neoplasm, some have cytotoxic T-cell neoplasm (Suzumiya et al, 1994). The primary site of involvement is the nasal cavity, but sometimes identical neoplasms primarily develop in the extranasal sites.…”

Section: Extranodal Nk/t-cell Lymphomamentioning

confidence: 99%

“…(2) Immunophenotype is as follows; CD45(LCA) + sCD3 ) cCD3e + CD56 + , myeloid antigens ) , and B-cell antigens ) (Suzumiya et al, 1994). Cytotoxic granule-associated proteins, granzyme B, TIA-1 and perforin, are positive.…”

Section: Diagnosismentioning

confidence: 99%

Progress in understanding and managing natural killer‐cell malignancies

2007

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SummaryThe World Health Organization classification of haematolymphoid tumours recognizes three categories of natural killer (NK)-cell neoplasms: blastic NK-cell lymphoma, aggressive NK-cell leukaemia, and extranodal NK/Tcell lymphoma, nasal-type. Recent studies indicate that CD4 + CD56 + blastic NK-cell lymphoma is of plasmacytoid dendritic cell origin, and true tumours of precursor NK-cell origin may be present mainly in the CD4Myeloid/NK-cell precursor acute leukaemia may also develop from precursor NK cells. However, because the developmental pathway of normal NK cells is not well understood, tumours of precursor NK-cell origin are not clearly identified. Among mature NK-cell tumours, extranodal NK/T-cell lymphoma is relatively common in Asia and Latin America. In localized disease, chemoradiotherapy seems to be promising, and in advanced disease, new combination chemotherapies are under active investigation. Aggressive NK-cell leukaemia is rare and has a poor prognosis. Because NK-cell neoplasms are rare and difficult to manage, rigorous studies are required for their understanding and management.

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“…For determination of cell lineage, immunohistochemical examination with various monoclonal antibodies and Southern blotting of T-cell receptor genes were performed, as previously described [20]. In addition, diagnosis of ATLL was confirmed by demonstration of the monoclonal integration of human T lymphotropic virus type-I (HTLV-I) by Southern blotting [21].…”

Section: Tissuesmentioning

confidence: 99%

Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T‐cell lymphomas

Nabeshima¹,

Suzumiya²,

Nagano³

et al. 2004

The Journal of Pathology

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Degradation of the extracellular matrix by matrix metalloproteinases (MMPs) is a crucial step in tumour invasion and metastasis. In human carcinomas, tumour cell-fibroblast interactions (TFIs) have been demonstrated to play a role in the up-regulation of MMP levels in tumours, and emmprin is a surface molecule on tumour cells that stimulates nearby fibroblasts to produce MMP-1, 2, and 3. T-cell lymphomas frequently show extranodal organ involvement and skin invasion, but a role for TFIs in their invasion has not been examined in detail. This study investigated TFIs in T-cell lymphomas with special reference to emmprin expression and MMP production. Immunohistochemically, only germinal centre cells and some histiocytes expressed emmprin in non-neoplastic lymph nodes (ten cases), while all T-cell lymphomas [14 cases of adult T-cell leukaemia/lymphoma (ATLL), six cases of lymphoblastic lymphoma, seven cases of anaplastic large cell lymphoma, and nine cases of angio-immunoblastic T-cell lymphoma] expressed emmprin strongly and diffusely. FACS analysis of peripheral blood from normal individuals revealed that small fractions of B-cells, T-cells, and monocytes expressed emmprin, whereas emmprin-expressing T-cells were much increased in number, and expressed this protein to a higher level, in ATLL patients. In vitro co-cultures of emmprin-positive HTLV-1-transformed lymphocytes (MT-2) and emmprin-negative human fibroblasts enhanced the production of pro-MMP-2 (gelatinase A) and active MMP-2, compared with cultures of either cell type alone. This stimulation was inhibited by an activity-blocking peptide against emmprin. Moreover, in histopathological sections from patients with ATL skin involvement, MMP-2 was demonstrated in fibroblasts around infiltrating ATL cells, but not in fibroblasts in non-diseased areas. In conclusion, emmprin is overexpressed by T-lymphoma cells, when compared with normal counterparts, and facilitates MMP-2 production via interactions with fibroblasts, which could play a role in stromal invasion by lymphoma cells.

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Expression of adult and fetal natural killer cell markers in sinonasal lymphomas [see comments]

Cited by 18 publications

References 0 publications

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal‐type natural killer‐cell lymphoma

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal‐type natural killer‐cell lymphoma

Progress in understanding and managing natural killer‐cell malignancies

Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T‐cell lymphomas

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