Expression of adhesion proteins (E-cadherin and β-catenin) and cell proliferation (Ki-67) at the invasive tumor front in conventional oral squamous cell and basaloid squamous cell carcinomas

Pereira, Cristiane Aparecida; Morais, Marília Oliveira; Martins, Allisson Filipe Lopes; Soares, Mariana Quirino Silveira; Alencar, Rita de Cássia Gonçalves; Batista, Aline Carvalho; Leles, Cláudio Rodrigues

doi:10.1016/j.archoralbio.2015.10.003

Cited by 21 publications

(20 citation statements)

References 42 publications

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“…Similar findings are reported by others [25][26][27], where a decreased expression of E-cadherin in tumor cells was detected in comparison to the strong expression of the same molecule in NOM.…”

Section: Comparing the Immuno-expression Of Endothelial Markers In Nosupporting

confidence: 79%

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Alej

Fernández

Marshall

et al. 2017

MOJAP

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Objective: To evaluate the expression of E-cadherin, Vimentin, CD31, CD117 in Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC), in comparison with Normal Oral Mucosa (NOM). Material and Methods:Descriptive case study. Histological samples were analyzed by immunohistochemistry against E-cadherin, Vimentin, CD31, CD117. E-cadherin expression was evaluated by extent and intensity, Vimentin was evaluated by intensity and CD31 and C117 quantitatively. Results:The extent of E-cadherin was greater than 75% in all NOM samples, 81% of the OED samples and 47% of the OSCC samples. The intensity of E-cadherin was high in NOM (100%) and in OSCC (36%). Mean CD31 was 21.2 ± 5 in NOM samples, 23.4 ± 5.8 in OED samples and 36.7 ± 10.8 in OSCC samples. Mean CD117 was 7.2 ± 2.5 in NOM samples, 12.8 ± 5.3 in OED samples and 22.7 ± 5.3 in OSCC samples. Conclusion:The molecular marker E-cadherin is significantly more downregulated in dysplastic cells in comparison to NOM cells, while the mesenchymal marker Vimentin is expressed by epithelial cells in samples of NOM, OED and OSCC; questioning their value as prognostic markers. Finally, the quantification of CD31 and CD117 increased significantly in OSCC samples.

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Section: Comparing the Immuno-expression Of Endothelial Markers In Nosupporting

confidence: 79%

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Alej

Fernández

Marshall

et al. 2017

MOJAP

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“…Controversy about the more aggressive behavior of BSCC compared to SCC have been discussed in the recent literature [3][4][5][6]25] and the study of cell cycle regulatory proteins may help to understand the differences in biological behavior in these two histological variants. In the present study, we demonstrated that both variants present an elevated number of cases presenting p53 and p16 abnormal expression.…”

Section: Discussionmentioning

confidence: 99%

“…Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC. BSCC may present as a more aggressive, poor-prognostic lesion compared to SCC; however, there is controversy regarding the true aggressive behavior of this variant [3][4][5][6], and some studies have demonstrated the effect of HPV infection on BSCC of the head and neck region [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

et al. 2018

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Purpose The true aggressive behavior of oral cavity BSCC compared to SCC has been debated, and the study of disturbances in cell cycle proteins may help understand the biological behavior in both variants. The aim of this study was to investigate the p53 and p16 status in 32 SCC and 16 BSCC of oral cavity. Methods Immunohistochemistry was used to assess these proteins' status. The association between p53 and p16 with clinicopathological features and prognostic value were evaluated. Results A high prevalence of p53 disruption was observed in both variants (84.4% of 32-SCC and 81.2% of 16-BSCC; p = 0.78). The BSCC showed a higher prevalence of high p16 expression (86.7% of 15) when compared to SCC (61.3% of 31); however, this difference did not reach statistical significance (p = 0.08). In the SCC variant, cases with high p16 expression showed a lower overall survival. Protein p53 showed association with tobacco use, but with no other clinicopathological features. Conclusions Our results suggest that p53 and p16 cell cycle disruptions are common findings in oral cavity SCC, as well as in BSCC. A higher prevalence of p16 overexpression in oral BSCC cases may be related to carcinogenesis process.

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“…A Ecaderina é expressa em todos tecidos epiteliais. Durante a proliferação celular de células neoplásicas ocorre uma diminuição na expressão de E-caderina que facilita a migração, invasão e metástase (Pereira et al, 2016;Zhang;Qin, 2014).…”

Section: E-caderinaunclassified

“…A marcação de E-caderina na mucosa normal era forte e contínua, diferente do que foi observado nas células neoplásicas, onde a expressão era mais fraca e descontínua (Pereira et al, 2016;Sridevi et al, 2015). …”

Section: E-caderinaunclassified

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

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Expression of adhesion proteins (E-cadherin and β-catenin) and cell proliferation (Ki-67) at the invasive tumor front in conventional oral squamous cell and basaloid squamous cell carcinomas

Cited by 21 publications

References 42 publications

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

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