Expression of activator proteins of SHH/GLI and PI3K/Akt/mTORC1 signaling pathways in human gliomas is associated with high grade tumors

Henao‐Restrepo, Julián; Caro-Urrego, Yudys Anggelly; Barrera-Arenas, Lina Marcela; Viana, Juan Carlos Arango; Bermudez-Muñoz, Maria

doi:10.1016/j.yexmp.2021.104673

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…Researchers reported that Gli1 and Gli2 expression is associated with grades III and IV gliomas with less survival. 236 The overall survival of patients with glioblastoma is decreased by upregulation of Shh based on data from the Cancer Genome Atlas glioblastoma. 237 …”

Section: Hedgehog Signaling In Cancermentioning

confidence: 99%

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Jing,

Wu,

Wang

et al. 2023

Sig Transduct Target Ther

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The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer. A variety of drugs have been developed, including small molecule inhibitors, natural compounds, and long non-coding RNA (LncRNA), some of which are approved for clinical use. This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer. Furthermore, we address status quo and limitations of targeted therapies of HH signaling pathway. Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer, as well as opportunities and challenges of therapeutic targets for cancer.

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Section: Hedgehog Signaling In Cancermentioning

confidence: 99%

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Jing,

Wu,

Wang

et al. 2023

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…In addition, the GLI1 expression levels were particularly high in grade III and IV gliomas, whereas GLI2 was found overexpressed only in grade III tumors. At the same time, GLI1-2 overexpression in these tumors was suggested to impact their progression, since high-grade gliomas patients exhibited worse survival rates [ 28 ]. Finally, it is evident that GLI factors play an important role in stem cell phenotype formation by sustaining the expression of related genes, such as OCT4 or SOX2 [ 29 ].…”

Section: Oncogenic Transcription Factorsmentioning

confidence: 99%

Transcription Factors with Targeting Potential in Gliomas

Giannopoulou

Kanakoglou

Piperi

2022

IJMS

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Gliomas portray a large and heterogeneous group of CNS tumors, encompassing a wide range of low- to high-grade tumors, as defined by histological and molecular characteristics. The identification of signature mutations and other molecular abnormalities has largely impacted tumor classification, diagnosis, and therapy. Transcription factors (TFs) are master regulators of gene expression programs, which ultimately shape cell fate and homeostasis. A variety of TFs have been detected to be aberrantly expressed in brain tumors, being highly implicated in critical pathological aspects and progression of gliomas. Herein, we describe a selection of oncogenic (GLI-1/2/3, E2F1–8, STAT3, and HIF-1/2) and tumor suppressor (NFI-A/B, TBXT, MYT1, and MYT1L) TFs that are deregulated in gliomas and are subsequently associated with tumor development, progression, and migratory potential. We further discuss the current targeting options against these TFs, including chemical (Bortezomib) and natural (Plumbagin) compounds, small molecules, and inhibitors, and address their potential implications in glioma therapy.

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“…By contrast, triggering the vasoactive intestinal peptide receptor system is triggered to reduce GBM cell migration and invasion through PKA-dependent PI3K/AKT and SHH/GLI1 pathway blocking (68). Similarly, Henao-Restrepo et al (69) reported that PI3K/AKT/mammalian target of rapamycin complex 1 (mTORC1) and SHH/GLI signaling pathway proteins were expressed differently in human gliomas with different tumor types and grades, suggesting that the activation of these signaling networks is related to the occurrence and development of high-grade gliomas.…”

Section: Molecular Mechanisms Of the Hh Signaling Pathway In Gbmmentioning

confidence: 99%

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

et al. 2022

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Glioblastoma (GBM) is the most common and fatal malignant tumor type of the central nervous system. GBM affects public health and it is important to identify biomarkers to improve diagnosis, reduce drug resistance and improve prognosis (e.g., personalized targeted therapies). Hedgehog (HH) signaling has an important role in embryonic development, tissue regeneration and stem cell renewal. A large amount of evidence indicates that both normative and non-normative HH signals have an important role in GBM. The present study reviewed the role of the HH signaling pathway in the occurrence and progression of GBM. Furthermore, the effectiveness of drugs that target different components of the HH pathway was also examined. The HH pathway has an important role in reversing drug resistance after GBM conventional treatment. The present review highlighted the relevance of HH signaling in GBM and outlined that this pathway has a key role in the occurrence, development and treatment of GBM. Contents 1. Introduction 2. Overview of GBM 3. The HH signaling pathway 4. Molecular mechanisms of the HH signaling pathway in GBM 5. Targeting the HH signaling pathway in GBM 6. HH pathway and immunotherapy 7. Discussion 8. Conclusion

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Expression of activator proteins of SHH/GLI and PI3K/Akt/mTORC1 signaling pathways in human gliomas is associated with high grade tumors

Cited by 6 publications

References 65 publications

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Transcription Factors with Targeting Potential in Gliomas

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

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