Expression form of p53 and PCNA at the invasive front in oral squamous cell carcinoma: correlation with clinicopathological features and prognosis

Kato, Koroku; Kawashiri, Shin‐ya; Yoshizawa, Kunio; Kitahara, Hiroko; Okamune, Ayako; Sugiura, Shirou; Noguchi, Naoto; Yamamoto, Etsuhide

doi:10.1111/j.1600-0714.2011.01032.x

Cited by 42 publications

(50 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tumour growth is associated with the actions of proliferative proteins such as proliferating cell nuclear antigen (PCNA), a non-histamine nuclear protein that is considered a specific marker of cell division (9,44). The expression of PCNA has been found to be correlated with the degree of malignancy and progression of cancer (45). The strong correlation between PCNA and VEGF detected in the present study indicates that VEGF, which is secreted by neoplastic cells, may induce self-proliferation in an autocrine manner, contributing to neoplastic growth, and induce endothelial cell proliferation and tumour angiogenesis through a paracrine mechanism.…”

Section: Oscc Grade -------------------------------------------------mentioning

confidence: 51%

Immunohistochemical expression of vascular endothelial growth factor in canine oral squamous cell carcinomas

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Oscc Grade -------------------------------------------------mentioning

confidence: 51%

Immunohistochemical expression of vascular endothelial growth factor in canine oral squamous cell carcinomas

et al. 2015

View full text Add to dashboard Cite

show abstract

“…As an important cell proliferation marker, PCNA plays an essential role in DNA replication and repair [20]. Its expression and distribution are closely associated with the rate of cellular proliferation and DNA synthesis [29]. This study found that the elevated expression of LARP1 correlated positively with PCNA expression, suggesting that LARP1 mediated cancer cell proliferation.…”

Section: Discussionmentioning

confidence: 88%

Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target

Lin

et al. 2016

Tumor Biol.

View full text Add to dashboard Cite

This study investigated the significance of La-related protein 1 (LARP1) in the development and progression of colorectal cancer (CRC). Quantitative real-time polymerase chain reaction and Western blot analyses were carried out to determine the mRNA and protein expression of LARP1 in CRC tumor tissues and paired adjacent normal mucosa. The expression of LARP1 was upregulated in CRC. Immunohistochemical analysis using tissue microarray was performed. A positive correlation between LARP1 and proliferating cell nuclear antigen (PCNA) in the area of proliferation was observed using the Spearman’s correlation coefficient test (r = 0.332, P < 0.01). The elevated expression of LARP1 significantly correlated with T stage (P = 0.02), N stage (P = 0.006), M stage (P < 0.001), American Joint Committee on Cancer (AJCC) stage (P = 0.04), differentiation rank (P < 0.001), and PCNA level (P < 0.001). In addition, the inhibitory effect of LARP1 knockdown on CRC cell proliferation was demonstrated using Cell Counting Kit-8 (CCK8) and colony-forming cell (CFC) assays. Multivariate analysis showed that LARP1 was an independent prognostic factor for overall survival (OS; hazard rate (HR) = 0.244; 95 % confidence interval (CI), 0.078–0.769; P = 0.016) and disease-free survival (DFS; HR = 0.281; 95 % CI, 0.086–0.917; P = 0.035) in CRC patients. LARP1 plays an important role in the proliferation of colorectal cancer and represents a new prognostic indicator.

show abstract

“…PCNA is a cofactor of DNA polymerase δ which is necessary for cell proliferation, so it is often used as an index of DNA replication and cell proliferation [23]. Tumor PCNA expression in each group were shown in Figure 6C.…”

Section: Resultsmentioning

confidence: 99%

Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy

Liu

Wang

et al. 2016

Oncotarget

View full text Add to dashboard Cite

The co-delivery of drug and gene has become the primary strategy in cancer therapy. Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of β-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery. Different from commonly used amphiphilic copolymers micelles, the obtained CD derivative could be used directly for the combinatorial delivery of nucleic acid and hydrophobic DOC without a complicated micellization process. In vitro and in vivo assays are carried out to confirm the effectiveness of the target strategy and combined treatment. It was found that the conjugation of CD-PLLD with FA could enhance the DOC/MMP-9 delivery effect obviously, inducing a more significant apoptosis and decreasing invasive capacity of HEN-1 cells. In vivo assays showed that FA-CD-PLLD/DOC/MMP-9 could inhibit HNE-1 tumor growth and decrease PCNA expression effectively, indicating a promising strategy for nasopharyngeal carcinoma therapy. Moreover, the in vivo distribution of DOC and MMP-9, blood compatibility and toxicity are also explored.

show abstract

Expression form of p53 and PCNA at the invasive front in oral squamous cell carcinoma: correlation with clinicopathological features and prognosis

Abstract: We suggest that it is important to investigate the expression of p53 and PCNA at the invasive front of OSCC.

Cited by 42 publications

References 31 publications

Immunohistochemical expression of vascular endothelial growth factor in canine oral squamous cell carcinomas

Immunohistochemical expression of vascular endothelial growth factor in canine oral squamous cell carcinomas

Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target

Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy

Contact Info

Product

Resources

About