Expression Dynamics of Heat Shock Proteins (HSP) in Livestock under Thermal Stress

Dangi, S.S.; Bharati, Jaya; Samad, Hari Abdul; Bhure, S K; Singh, Gyanendra; Maurya, V. P.; Sarkar, Mihir; Kumar, Puneet

doi:10.1007/978-3-319-73377-7_2

Cited by 4 publications

(3 citation statements)

References 234 publications

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“…Heat stress negatively affects immunity and modulates immune responses to PAMPs. HSPs can be actively secreted by tumor or necrotic cells extracellularly and can present as substitute ligands for PRRs, hence triggering innate immune responses [ 173 ]. HSP60/70/90 plays a key role in the stimulation of innate immunity.…”

Section: Cytoprotective Role Of Hsps Against Heat-stress-induced Imentioning

confidence: 99%

Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Shehata

Saadeldin

Tukur

et al. 2020

Animals

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Heat stress is one of the most challenging environmental stresses affecting domestic animal production, particularly commercial poultry, subsequently causing severe yearly economic losses. Heat stress, a major source of oxidative stress, stimulates mitochondrial oxidative stress and cell dysfunction, leading to cell damage and apoptosis. Cell survival under stress conditions needs urgent response mechanisms and the consequent effective reinitiation of cell functions following stress mitigation. Exposure of cells to heat-stress conditions induces molecules that are ready for mediating cell death and survival signals, and for supporting the cell’s tolerance and/or recovery from damage. Heat-shock proteins (HSPs) confer cell protection against heat stress via different mechanisms, including developing thermotolerance, modulating apoptotic and antiapoptotic signaling pathways, and regulating cellular redox conditions. These functions mainly depend on the capacity of HSPs to work as molecular chaperones and to inhibit the aggregation of non-native and misfolded proteins. This review sheds light on the key factors in heat-shock responses for protection against cell damage induced by heat stress in chicken.

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Section: Cytoprotective Role Of Hsps Against Heat-stress-induced Imentioning

confidence: 99%

Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Shehata

Saadeldin

Tukur

et al. 2020

Animals

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“…Heat shock protein (HSP) is a cellular and tissue defense mechanism and is expressed in high volumes during heat shock (Archana et al, 2017). If overexpressed, it protects the animal against hyperthermia during heat stroke which signi es the pivotal role of HSP in cytoprotection (Dangi et al, 2017). The LMAN2 gene identi ed on BTA 7 using the F ST approach in the NGI-versus-TUL pairwise comparison, was also previously associated with functions of heat shock protein binding (GO:0031072) in beef cattle (Ghebrewold, 2018).…”

Section: Discussionmentioning

confidence: 99%

Selection signatures associated with adaptation in South African Drakensberger, Nguni, and Tuli beef breeds

Gomo,

Marle-Köster,

Lashmar

et al. 2024

Preprint

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Climate change is an important consideration for sustainable beef production systems. Sanga cattle (Bos taurus africanus) are a unique genetic resource known for their adaptability to diverse climates. Genomic technologies have allowed opportunities to investigate indigenous cattle at the deoxyribonucleic acid (DNA) and genome level for insight into variation associated with adaptive traits. 1709 cattle, including 1118 Drakensberger (DRB), 377 Nguni (NGI), and 214 Tuli (TUL), were genotyped using the GeneSeek® Genomic Profiler™ 150K bovine SNP panel. 122632 quality-filtered SNPs was used to assess runs of homozygosity (ROH) and runs of heterozygosity (ROHet) within the three cattle populations using the detectRUNS R package (Biscarini et al., 2018) and PLINK v1.90 (Purcell et al., 2007). The study identified selection signatures associated with adaptation within-and-between three breeds based on ROH, ROHet, and FST-based differentiation of SNPs. The mean number of ROH per animal varied across breeds ranging from 36.09 ± 12.82 (NGI) to 51.82 ± 21.01 (DRB), and the mean ROH length per breed ranged between 2.31Mb (NGI) and 3.90Mb (DRB). The smallest length categories i.e., ROH < 4Mb and ROHet < 0.25Mb were most frequent, indicating predominantly historic inbreeding effects for all breeds. The ROH based inbreeding coefficients (FROH) ranged between 0.033 ± 0.024 (NGI) and 0.081 ± 0.046 (DRB). Genes mapped to candidate regions were associated with immunity (ADAMTS12, CYSTM1, WDPCP) and adaptation (LMAN2, TUBB3) in cattle as well as genes previously only reported for immunity in mice and human (EXOC3L1, MYO1G). This study contributes to the understanding of the mechanisms of adaptation, providing information for functional genomic studies and application in genetic evaluation and selection programs.

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“…HSP also acts in the degradation of proteins that cannot be refolded properly and can interact with other proteins and modulate their activity or stability, influencing various cellular processes such as cell cycle progression and apoptosis [ 41 ]. HSP activities have been reported to minimize HS-induced cellular death and improve thermotolerance in livestock [ 43 ] and to regulate the immune response, including stimulatory and regulatory functions [ 44 ]. In this study, we found genomic regions associated with T SS , T RS , and T TS overlapping with HSBP1L1 (Heat Shock Factor Binding Protein 1 Like 1) and regions associated with EA overlapping with the HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) gene.…”

Section: Discussionmentioning

confidence: 99%

Genomic regions, candidate genes, and pleiotropic variants associated with physiological and anatomical indicators of heat stress response in lactating sows

de Oliveira,

Veroneze,

Sousa

et al. 2024

BMC Genomics

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Background Heat stress (HS) poses significant threats to the sustainability of livestock production. Genetically improving heat tolerance could enhance animal welfare and minimize production losses during HS events. Measuring phenotypic indicators of HS response and understanding their genetic background are crucial steps to optimize breeding schemes for improved climatic resilience. The identification of genomic regions and candidate genes influencing the traits of interest, including variants with pleiotropic effects, enables the refinement of genotyping panels used to perform genomic prediction of breeding values and contributes to unraveling the biological mechanisms influencing heat stress response. Therefore, the main objectives of this study were to identify genomic regions, candidate genes, and potential pleiotropic variants significantly associated with indicators of HS response in lactating sows using imputed whole-genome sequence (WGS) data. Phenotypic records for 18 traits and genomic information from 1,645 lactating sows were available for the study. The genotypes from the PorcineSNP50K panel containing 50,703 single nucleotide polymorphisms (SNPs) were imputed to WGS and after quality control, 1,622 animals and 7,065,922 SNPs were included in the analyses. Results A total of 1,388 unique SNPs located on sixteen chromosomes were found to be associated with 11 traits. Twenty gene ontology terms and 11 biological pathways were shown to be associated with variability in ear skin temperature, shoulder skin temperature, rump skin temperature, tail skin temperature, respiration rate, panting score, vaginal temperature automatically measured every 10 min, vaginal temperature measured at 0800 h, hair density score, body condition score, and ear area. Seven, five, six, two, seven, 15, and 14 genes with potential pleiotropic effects were identified for indicators of skin temperature, vaginal temperature, animal temperature, respiration rate, thermoregulatory traits, anatomical traits, and all traits, respectively. Conclusions Physiological and anatomical indicators of HS response in lactating sows are heritable but highly polygenic. The candidate genes found are associated with important gene ontology terms and biological pathways related to heat shock protein activities, immune response, and cellular oxidative stress. Many of the candidate genes with pleiotropic effects are involved in catalytic activities to reduce cell damage from oxidative stress and cellular mechanisms related to immune response.

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Expression Dynamics of Heat Shock Proteins (HSP) in Livestock under Thermal Stress

Cited by 4 publications

References 234 publications

Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Selection signatures associated with adaptation in South African Drakensberger, Nguni, and Tuli beef breeds

Genomic regions, candidate genes, and pleiotropic variants associated with physiological and anatomical indicators of heat stress response in lactating sows

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