Expression, Clinical Significance, and Prospective Pathway Signaling of miR-501-3p in Ovarian Cancer Based on Database and Informatics Analysis

Chen, Buze; Jin, Xin; Wang, Haihong; Zhou, Qingmei; Li, Guilin; Lü, Xiaoyuan

doi:10.2147/ijgm.s327673

Cited by 6 publications

(12 citation statements)

References 25 publications

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“…Correlation analysis of gene expression with clinical characteristics was carried out according to reference [ 16 ]. R (version 3.6.3) was used for statistical analysis and visualization.…”

Section: Methodsmentioning

confidence: 99%

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miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma

Lü

Wang

et al. 2022

International Journal of Endocrinology

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Background. Endocrine disruption is an important factor in the development of endometrial cancer. Expression of miR-149-3p is observed in some cancer types, while its role in uterine corpus endometrial carcinoma (UCEC) is unclear. Methods. The clinical and genomic data and prognostic information on UCEC were obtained for patients from the TCGA database. The Kruskal–Wallis test, Wilcoxon signed-rank test, and logistic regression were used to analyze the relationship between clinical characteristics and miR-149-3p expression. Kaplan–Meier survival curve analysis was used to study the influence of miR-149-3p expression and miR-149-3p target genes on the prognosis of UCEC patients. The TargetScan, PicTar, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to determine the involvement of miR-149-3p target genes in function. Immune infiltration analysis was used to analyze the functional involvement of miR-149-3p. QRT-PCR was used to validate the expression of miR-149-3p in UCEC cell lines. Results. High expression of miR-149-3p in UCEC was significantly associated with age ( P < 0.001 ), histological type ( P < 0.001 ), histological grade ( P < 0.001 ), tumor invasion ( P = 0.014 ), and radiation therapy ( P = 0.011 ). High miR-149-3p expression predicted poorer overall survival (OS) (HR: 2.56; 95% CI: 1.64–4.00; P < 0.001 ), progression-free interval (PFI) (HR: 1.85; 95% CI: 1.29–2.65; P = 0.001 ), and disease-specific survival (DSS) (HR: 2.33; 95% CI: 1.37–3.99; P = 0.002 ). Low expressions of miR-149-3p target genes, including ADCYAP1R1, CGNL1, CHST3, CYGB, DNAH9, ESR1, HHIP, HIC1, HOXD11, IGF1, INMT, LSP1, MTMR10, NFIC, PLCE1, RARA, SNTN, SPRYD3, and ZBTB7A, were associated with poor OS in UCEC. MiR-149-3p may be involved in the occurrence and development of UCEC via pathways including PI3K-Akt signaling pathway, Ras signaling pathway, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, and MAPK signaling pathway. miR-149-3p may inhibit the function of CD8 T cells, cytotoxic cells, eosinophils, iDC, mast cells, neutrophils, NK CD56bright cells, NK CD56dim cells, pDC, T cells, T helper cells, TFH, Th17 cells, and Treg. miR-149-3p was significantly upregulated in UCEC cell lines compared with endometriotic stromal cells. Conclusion. High expression of miR-149-3p was significantly associated with poor survival in UCEC patients. It may be a promising biomarker of prognosis and response to immunotherapy for UCEC patients.

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“…Correlation analysis of gene expression with clinical characteristics was carried out according to reference [ 16 ]. R (version 3.6.3) was used for statistical analysis and visualization.…”

Section: Methodsmentioning

confidence: 99%

“…The Kaplan–Meier method analysis was carried out according to references [ 16 , 17 ]. R (version 3.6.3) was used for statistical analysis and visualization.…”

Section: Methodsmentioning

confidence: 99%

miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma

Lü

Wang

et al. 2022

International Journal of Endocrinology

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“…Analytical methods referred to the published reference. 16 Molecule: hsa-miR-195-3p [MIMAT0004615]. The data includes miRNAseq data and clinical data from the BCGSC level 3 miRNA profile analysis of the TCGA ( https://portal.gdc.cancer.gov/ ) and LUAD (lung adenocarcinoma) project.…”

Section: Methodsmentioning

confidence: 99%

“…Analytical methods referred to the published reference. 16 The molecule is hsa-miR-195-3p. Clinical variables: Normal vs Tumor.…”

Section: Methodsmentioning

confidence: 99%

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MiR-195-3p is a Novel Prognostic Biomarker Associated with Immune Infiltrates of Lung Adenocarcinoma

Liu¹,

Li²,

Xie³

et al. 2022

IJGM

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Background: plays an important role in some tumors, but its role in LUAD is unclear. This study explored the expression of miR-195-3p in LUAD and the relationship between the expression of miR-195-3p and the clinical and prognostic characteristics of LUAD patients. Methods: MiR-195-3p expression and clinical information of LUAD patients were obtained from The Cancer Genome Atlas (TCGA). Kruskal-Wallis test, Wilcoxon signed rank test, logistic regression, and Cox regression were used to assess the relationship between the expression level of miR-195-3p and clinical features in LUAD tissues. Kaplan-Meier survival curves were used to analyze the effect of miR-195-3p expression levels on the prognosis of LUAD patients. Target genes of miR-195-3p were predicted by several software. GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes), and immune infiltration analysis were used to analyze the possible regulatory network of miR-195-3p. Results: Compared with normal lung tissue, miR-195-3p is down expressed in LUAD tissue (P < 0.001). The low miR-195-3p expression in LUAD was significantly associated with N stage (P = 0.046), pathologic stage (P = 0.011), and gender (P = 0.010). Low miR-195-3p expression predicted a poorer overall survival (HR: 0.60; 95% CI: 0.45-0.81; P = 0.001) and disease-specific survival (HR: 0.55; 95% CI: 0.37-0.80; P = 0.002). The expression of miR-195-3p (HR: 0.488; 95% CI: 0.304-0.784; P = 0.003) was independently correlated with OS in LUAD patients. High expression of miR-195-3p genes, including ABCC2, AGMAT,

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MicroRNA target prediction tools for animals: Where we are at and where we are going to - A systematic review

Feitosa

Prieto-Oliveira

Brentani

et al. 2022

Computational Biology and Chemistry

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Expression, Clinical Significance, and Prospective Pathway Signaling of miR-501-3p in Ovarian Cancer Based on Database and Informatics Analysis

Cited by 6 publications

References 25 publications

miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma

miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma

MiR-195-3p is a Novel Prognostic Biomarker Associated with Immune Infiltrates of Lung Adenocarcinoma

MicroRNA target prediction tools for animals: Where we are at and where we are going to - A systematic review

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