Expression and significance of interferon regulatory factor 3 of peripheral blood dendritic cells in HBV-infected patients

An, Bao-Yan; Xie, Qing; Wang, Hui; Jia, Ni-Na; Shen, Huai-Cheng; Cai, Wei; Yu, Haifeng; Guo, Qing

doi:10.11569/wcjd.v16.i17.1873

Cited by 5 publications

(1 citation statement)

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“…Decreased TLR3, RIG‐I and MDA‐5 level may be the reason for the shortage of type I IFN secretion . Analysis of the intracellular type I IFN induction pathway in DCs from patients with CHB has shown that the expression of IRF‐3 is decreased and that the sensitivity upon poly(I:C) stimulation and IFN‐β production are all significantly insufficient .…”

Section: Molecular Mechanism Of the Hbv‐induced Suppression Of Type Imentioning

confidence: 99%

Suppression of Interferon‐Mediated Antiviral Immunity by Hepatitis B Virus: An Overview of Research Progress

Guo

2013

Scand J Immunol

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Interferon (IFN)-a is an indispensable drug for hepatitis B treatment in clinical settings. However, hepatitis B virus (HBV) can attenuate IFN-mediated antiviral responses to avoid being inhibited or cleared. Much progress has been made in exploring how the IFN-induced anti-HBV effect is inhibited. This review examines and summarizes new advances regarding the molecular mechanism underlying the HBV-induced suppression of type I IFN-mediated antiviral immunity.

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Section: Molecular Mechanism Of the Hbv‐induced Suppression Of Type Imentioning

confidence: 99%

Suppression of Interferon‐Mediated Antiviral Immunity by Hepatitis B Virus: An Overview of Research Progress

Guo

2013

Scand J Immunol

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TLR3 plays significant roles against hepatitis B virus

Karimi-Googheri

Arababadi

2014

Mol Biol Rep

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Hepatitis B virus (HBV) as the main prevalent infectious agent, play important roles in inducing severe liver diseases. Previous studies demonstrated that during prolonged forms of hepatitis B infection including chronic, asymptomatic and occult forms, patients are unable to eradicate HBV from hepatocytes completely. The main mechanisms responsible for development of the forms of hepatitis B are yet to be identified. Investigators suggested that the various genetic and immunological parameters of the patients may are responsible for resulting in the prolonged infection forms. It has been evidenced that TLRs play key roles in inducing appropriate immune responses, against viral infections. Therefore, these molecules can be considered as crucial sensors for HBV detection to induce immune responses against this virus. It has also been documented that the TLR3 detects intracellular viral dsRNA and subsequently activates NF-κB via the TRIF pathway. Therefore, impaired TLR3 expression may result in inappropriate immune responses against HBV which is reported in prolonged forms of hepatitis B. This review collected the recent information regarding the important roles of TLR3 in immune responses against HBV and also the status of TLR3 expression and its genetic variations in prolonged forms of HBV infections.

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Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients

et al. 2014

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Expression and significance of interferon regulatory factor 3 of peripheral blood dendritic cells in HBV-infected patients

Cited by 5 publications

References 0 publications

Suppression of Interferon‐Mediated Antiviral Immunity by Hepatitis B Virus: An Overview of Research Progress

Suppression of Interferon‐Mediated Antiviral Immunity by Hepatitis B Virus: An Overview of Research Progress

TLR3 plays significant roles against hepatitis B virus

Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients

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