Expression and shedding of CD44 in the endometrium of women with endometriosis and modulating effects of vitamin D: A randomized exploratory trial

Pazhohan, Azar; Amidi, Fardin; Akbari-Asbagh, Firoozeh; Seyedrezazadeh, Ensiyeh; Aftabi, Younes; Abdolalizadeh, Jalal; Khodarahmian, Mahshad; Khanlarkhani, Neda; Sobhani, Aligholi

doi:10.1016/j.jsbmb.2017.12.001

Cited by 27 publications

(18 citation statements)

References 63 publications

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“…On the other hand, only a few studies have examined adhesion molecule expression in the eutopic and ectopic endometrial tissues of women with endometriosis, and the studies that have examined this subject yielded controversial results. Some of these studies demonstrated that both CD44 and E-cadherin expressions were higher in the eutopic and/or ectopic endometrial tissues of women with endometriosis than in control endometrial tissues [33][34][35]. Contrary to these reports, Poncelet et al found that the expression of CD44 and E-cadherin in epithelial cells was lower in cases of peritoneal endometriosis than in normal endometrium [36].…”

Section: Discussionmentioning

confidence: 94%

Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables

Usta

Turan

Bülbül

et al. 2020

Reprod Biol Endocrinol

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Background Endometriosis is an estrogen-dependent inflammatory disease that often causes infertility and chronic pelvic pain. Although endometriosis is known as a benign disease, it has demonstrated characteristics of malignant neoplasms, including neoangiogenesis, tissue invasion, and cell implantation to distant organs. Octamer-binding protein 4 (Oct-4) is a molecular marker for stem cells that plays an essential role in maintaining pluripotency and self–renewal processes in various types of benign and malignant tissues. CD44 is a multifunctional cell surface adhesion molecule that acts as an integral cell membrane protein and plays a role in cell–cell and cell–matrix interactions. E-cadherin is an epithelial cell–cell adhesion molecule that plays important role in the modulation of cell polarization, cell migration, and cancer metastasis. The aim of this study was to investigate the expression patterns of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrial tissues from women with endometrioma compared to control endometrial tissues from women without endometrioma. Methods In the present study, Oct-4, CD44, and E-cadherin expressions were evaluated in eutopic and ectopic endometrial tissue samples from women with endometrioma (n = 32) and compared with those of control endometrial tissue samples from women without endometrioma (n = 30). Results Immunohistochemical expression of Oct-4 was significantly higher in the ectopic endometrial tissue samples of women with endometrioma than in the control endometrial tissue samples (p = 0.0002). Conversely, CD44 and E-cadherin expressions were significantly lower in the ectopic endometrial tissue samples of women with endometrioma than in the control endometrial tissue samples (p = 0.0137 and p = 0.0060, respectively). Correlation analysis demonstrated significant correlations between Oct-4 expression and endometrioma cyst diameter (p = 0.0162), rASRM stage (p = 0.0343), and total rASRM score (p = 0.0223). Moreover, CD44 expression was negatively correlated with the presence of peritoneal endometriotic lesions (p = 0.0304) while E-cadherin expression was negatively correlated with the presence of deep infiltrating endometriosis (p = 0.0445). Conclusions Increased expression of Oct-4 and decreased expression of adhesion molecules in endometriotic tissues may contribute to the development and progression of endometriosis.

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Section: Discussionmentioning

confidence: 94%

Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables

Usta

Turan

Bülbül

et al. 2020

Reprod Biol Endocrinol

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“…The hyaluronic receptor CD44 molecule has an important role in cellular adhesion and T cells activation (Senbanjo and Chellaiah, 2017). Its increased expression in eutopic endometrium is correlated with a greater risk of EDT development (Pazhohan et al, 2018). Cd44 À/À mice were shown to have an impaired development of early endometriotic lesions (Knudtson et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Jeljeli¹,

Riccio²,

Chouzenoux³

et al. 2020

Cell Reports

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“…Авторы пришли к выводу, что витамин D может контролировать и изменять этот процесс. Ученые предлагают продол-жать исследования в данном направлении [65].…”

Section: рисунок 2 эффекты витамина Dunclassified

Global vitamin D status problems: causes, pathogenetic mechanisms, treatment, prevention measures

2018

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There is a need to improve the status of vitamin D. Vitamin D not only affects the processes of formation of the musculoskeletal system, but also actively participates in many extra-osseous effects of cholecalciferol. Modern publications point to a number of positive effects of vitamin D for people of all ages. The modern vitamin D3 preparation Detrimax is recommended as an active food additive (tablet form containing 1000 IU of vitamin D3 (cholecalciferol)) and corresponds to the most frequent daily requirement for vitamin D3. Prophylaxis of vitamin D deficiency should be a priority in health policy.

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Expression and shedding of CD44 in the endometrium of women with endometriosis and modulating effects of vitamin D: A randomized exploratory trial

Cited by 27 publications

References 63 publications

Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables

Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables

Macrophage Immune Memory Controls Endometriosis in Mice and Humans

Global vitamin D status problems: causes, pathogenetic mechanisms, treatment, prevention measures

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