Expression and role of Notch signalling in the regeneration of rat tracheal epithelium

Ma, Xiao-Bo; Jia, Xinshan; Liu, Y.-L.; Wang, L.-L.; Sun, Shan-Liang; Song, Nan; Wang, E.-H.; Li, F.

doi:10.1111/j.1365-2184.2008.00569.x

Cited by 19 publications

(17 citation statements)

References 36 publications

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“…In addition, reactivation of Moreover, results reflecting our data were described by Ma et al who revealed that NICD3 and Hey1 are upregulated after 5-fluorouracil induced injury of the rat tracheal epithelium (144). It is also known that Notch1 plays a major role in the control of the adaptive response of the heart to stress conditions (139) and is activated during liver regeneration (141), further confirming a possible involvement of the Notch pathway in pathomechasim of lung fibrosis.…”

Section: Reactivation Of the Notch Signaling Pathway In Lung Fibrosissupporting

confidence: 86%

“…During the injury a similar situation was observed in NICD3 localization of rat tracheal epithelial cells. It was suggested that Notch activation plays a role in the maintenance of an undifferentiated state of epithelial cells and the promotion of proliferation of cells (144). We suggest that NICD1 may have an impact on AECII transdifferentiation in AECI.…”

Section: Alveolar Epithelium As a Target Cell Type For Notch Signalingmentioning

confidence: 67%

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Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung

Piskulak¹,

Henneke²,

Wilhelm³

et al. 2012

Pneumologie

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Section: Reactivation Of the Notch Signaling Pathway In Lung Fibrosissupporting

confidence: 86%

Section: Alveolar Epithelium As a Target Cell Type For Notch Signalingmentioning

confidence: 67%

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung

Piskulak¹,

Henneke²,

Wilhelm³

et al. 2012

Pneumologie

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“…The rationale for examining the Notch pathway in renal regeneration includes the role this pathway plays in the regenerative response to injury in adult tissues such as kidney, liver, bone marrow, skin, muscle, intestine, heart, trachea, and pancreas (1,16,17,24,30,31,36,42,48,54). In addition, Notch signaling is involved in self-renewal and cell-fate commitment of tissue stem cells (14,21).…”

mentioning

confidence: 99%

Effect of Notch activation on the regenerative response to acute renal failure

Gupta

Abedin

et al. 2010

American Journal of Physiology-Renal Physiology

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Episodes of acute renal failure (ARF) are not always fully reversible and may lead to chronic disease, due in part to an inadequate regenerative response. The Notch signaling pathway is involved in determining cell fate during development, and tissue maintenance and repair in adult organs. The purpose of this study was to examine the role of the Notch pathway in renal regeneration following ARF. Kidney injury, induced by ischemia-reperfusion, resulted in early activation of the Notch pathway, as evidenced by increased expression of Notch1 and Notch2 intracellular domain (cleaved Notch). The effect of exogenous administration of the Notch ligand Delta-like-4 (DLL4) on recovery from ARF was then studied. Rats were pretreated by intraperitoneal injection of DLL4 or vehicle control. Two days following the last DLL4 dose, ARF was induced by bilateral renal artery clamping for 45 min followed by reperfusion. The severity of renal injury was similar in DLL4 and control rats. Renal recovery was facilitated by DLL4 treatment, as evidenced by faster return of serum creatinine to baseline by 48 h in DLL4-treated rats as against 5 days in vehicle-treated control rats. Cell proliferation was higher in the DLL4-treated group. In conclusion, activation of the Notch pathway occurs following ARF. Pretreatment with the Notch ligand DLL4 enhanced recovery from ARF and represents a potential novel therapeutic option for regenerating the injured kidney.

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“…It has been reported that NOTCH1, another molecule in Notch family members, expression is associated with cell aggressiveness and 5-FU drug resistance in human esophageal squamous cell carcinoma cell lines in vitro, and also with poor survival in human esophageal squamous cell carcinomas (19). It has also been reported that expression levels of Notch3 were increased in rat tracheal epithelial cells after treatment with 5-FU (20). NOTCH3 knockdown enhanced the sensitivity of nasopharyngeal carcinoma cells to CDDP treatment (21), and NOTCH3 overexpression correlated with shorter progressionfree/overall survival in patients with advanced stage ovarian carcinoma treated with platinum and taxane (22).…”

Section: Discussionmentioning

confidence: 82%

Alteration of gene expression and DNA methylation in drug-resistant gastric cancer

et al. 2014

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Abstract. The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)-and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were established with culture for >10 months in a medium containing 5-FU or CDDP. Endoscopic biopsy specimens were obtained from gastric cancer patients who underwent chemotherapy with oral fluoropyrimidine S-1 and CDDP. Gene expression and DNA methylation analyses were performed using microarray, and validated using real-time PCR and pyrosequencing, respectively. Out of 17,933 genes, 541 genes commonly increased and 569 genes decreased in both 5-FU-and CDDP-resistant AGS cells. Genes with expression changed by drugs were related to GO term 'extracellular region' and 'p53 signaling pathway' in both 5-FU-and CDDP-treated cells. Expression of 15 genes including KLK13 increased and 12 genes including ETV7 decreased, in both drug-resistant cells and biopsy specimens of two patients after chemotherapy. Out of 10,365 genes evaluated with both expression microarray and methylation microarray, 74 genes were hypermethylated and downregulated, or hypomethylated and upregulated in either 5-FU-resistant or CDDP-resistant cells. Of these genes, expression of 21 genes including FSCN1, CPT1C and NOTCH3, increased from treatment with a demethylating agent. There are alterations of gene expression and DNA methylation in drug-resistant gastric cancer; they may be related to mechanisms of drug resistance and may be useful as biomarkers of gastric cancer drug sensitivity.

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Expression and role of Notch signalling in the regeneration of rat tracheal epithelium

Abstract: During tracheal epithelial regeneration, Notch signalling maintains an undifferentiated state and promotes proliferation among a population of tracheal epithelial cells.

Cited by 19 publications

References 36 publications

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung

Effect of Notch activation on the regenerative response to acute renal failure

Alteration of gene expression and DNA methylation in drug-resistant gastric cancer

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