Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells

Tomeczkowski, Jörg; Frick, D; Schwinzer, Beate; Wittner, Nicole; Ludwig, Wolf Dieter; Reiter, Alfred; Welte, Karl; Sykora, Karl Walter

doi:10.1038/sj.leu.2401102

Cited by 20 publications

(22 citation statements)

References 40 publications

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“…Bcl-6 expression is less often observed in T-LBL with a DN phenotype [26], while CD117 is known to play a role in early thymocyte (DN stage) development [27]. CD117 expression was reported in up to 40% of patients with T-ALL/LBL [28], and is more commonly seen in cases with the most immature phenotypes [29]. Expression of CD13, a non-Trestricted marker, is often observed in CD117+ TLBLs [29], probably reflecting a prethymic precursor phenotype.…”

Section: Discussionmentioning

confidence: 99%

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

et al. 2005

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Non-Hodgkin lymphoma of T-cell lineage involving the breast is rare. We report on a 41-year-old woman with T-cell lymphoblastic lymphoma who presented with multiple bilateral breast masses. The patient was treated with intensive chemotherapy and mediastinal and whole-brain irradiation. She remains in complete remission 24 months after diagnosis. The clinical, histologic, phenotypic, and cytogenetic features are described, with a review of the literature. Am.

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Section: Discussionmentioning

confidence: 99%

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

et al. 2005

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“…Kit is upregulated by BMP4 in mitotic spermatogonia It has been shown that TGF-β can downregulate c-kit expression in hemopoietic cells (Sansilvestri et al, 1995;Heinrich et al, 1995), while it upregulates c-kit expression in T-leukemia cells and in melanoblasts (Tomeczkowski et al, 1998;Kawakami et al, 2002). To date no reports have been obtained on the factors that regulate c-kit expression in germ cells.…”

Section: Smad4/5 and Cbp Form An Active Complex Upon Bmp4 Stimulationmentioning

confidence: 99%

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation

Pellegrini

Grimaldi

Rossi

et al. 2003

Journal of Cell Science

193

183

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“…Mutations of the receptor tyrosine kinase and oncogene c-KIT have been identified as a common event in some cases of AML and T-cell ALL (Goemans et al, 2005;Shih et al, 2008;Tomeczkowski et al, 1998). One study has shown in vitro that KIT exon 8 mutations transiently expressed in CHO cell line can result gain of function in constitutively activating a ligand-independent KIT kinase via autophosphorylation (Goemans et al, 2005).…”

Section: Supporting Publications 2016: En-955 113mentioning

confidence: 99%

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Choi¹,

Polcher²,

Joas³

2016

EFSA Supporting Publications

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This report presents the outcomes of a systematic review (SR) identifying the mechanisms and chemicals involved in the pathogenesis of Parkinson's disease (PD) and childhood leukaemia (CL). This work serves as a basis for defining and mapping the causal linkages between a molecular initiating event (MIE) and a final adverse outcome (AO) that are relevant for the development of a prototype adverse outcome pathway (AOP) for assessing risk factors for PD and CL. Search for literature from 1990 to present was conducted using Web of Science, PubMed and TOXNET, and relevant references were selected using established inclusion/exclusion criteria and ranked using a set of quality control factors.For PD, 7,384 individual references were identified to be relevant for PD pathogenesis and chemicals associated with PD. Dopaminergic neurodegeneration in the substantia nigra leading to locomotor deficits was identified as the AO in PD. Other identified key events in PD pathogenesis include mitochondrial dysfunction, cellular accumulation of alpha-synuclein and oxidative stress. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, rotenone and paraquat are some chemicals identified to be associated with PD pathogenesis.For CL, 1,988 individual references were identified to be relevant for CL pathogenesis and chemicals associated with CL. Chromosomal translocation, genetic damage/mutation and hyperdiploidy are considered as driving forces of CL. Except for infant leukaemia, CL pathogenesis requires a 'two-hit' model with an initiating event occurring in utero followed by a secondary hit potentially occurring after birth. Potential MIEs leading to these driving mechanisms include aberrant DNA topoisomerase II activity and erroneous DNA repair. Epigenetics appears to also play an influential role in CL pathogenesis. Benzene, bioflavonoids and organophosphates are some chemicals identified to be implicated in CL pathogenesis.The challenges of developing AOPs for these two diseases and the data gaps identified from the outcomes of this SR are also elaborated in this report. The present document has been produced and adopted by the bodies identified above as authors. This task has been carried out exclusively by the authors in the context of a contract between the European Food Safety Authority and the authors, awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. KEY WORDSSystematic Review, Parkinson Disease, Childhood Leukaemia, Pathogenesis, Chemicals, Pesticides, Adverse Outcome Pathway SUMMARYThe aim of this project was to perform a systematic review (SR) to collect relevant publications related to the mechanisms involved in the pathogenesis of Parkinson's disease (PD)...

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Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells

Abstract: The cytokine stem cell factor (SCF) synergizes with IL-7 to enhance the proliferation of thymocytes. We therefore investigated the role of the SCF receptor, the protooncogene c-kit, in the pathogenesis of pediatric T-lineage malignancies.

Cited by 20 publications

References 40 publications

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

T‐Cell lymphoblastic lymphoma presenting as bilateral multinodular breast masses: A case report and review of the literature

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

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