Expression and purification of active shikimate dehydrogenase from Plasmodium falciparum
BRUNO G. DALLA VECCHIA MORALES,
JOSEPH ALBERT M. EVARISTO,
GEORGE A.R. DE OLIVEIRA
et al.
Abstract:Plasmodium falciparum is known to cause severe malaria, current treatment consists in artemisinin-based combination therapy, but resistance can lead to treatment failure. Knowledge concerning P. falciparum essential proteins can be used for searching new antimalarials, among these a potential candidate is shikimate dehydrogenase (SDH), an enzyme part of the shikimate pathway which is responsible for producing endogenous aromatic amino acids. SDH from P. falciparum (PfSDH) is unexplored by the scientific commun… Show more
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