Expression and Prognostic Value of ARID5A and its Correlation With Tumor-Infiltrating Immune Cells in Glioma

Abstract

AT-rich interaction domain 5A (ARID5A) is a member of the ARID family with a function that has been linked to autoimmune as well as inflammatory diseases. Some ARID family members are involved in the initiation and progression of human cancers. However, the function of ARID5A in glioma remains unknown. In this study, ARID5A expression levels were analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. Subsequently, the relationship between ARID5A expression and the clinical characteristics of glioma patients was evaluated using the Chinese Glioma Genome Atlas (CGGA) database and The Cancer Genome Atlas (TCGA) database. The prognostic value of ARID5A in glioma was estimated by Kaplan-Meier analysis and the receiver operating characteristic (ROC) curve analysis. Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) were performed for functional prediction. The Tumor Immune Estimation Resource (TIMER) database was used to analyze the relationship between ARID5A and immune cell infiltration in glioma. Our results demonstrate that the expression of ARID5A was upregulated in glioma compared with that in nontumor brain tissues. High expression of ARID5A is associated with poor prognosis in glioma. We found that the expression of ARID5A was significantly upregulated with an increase in tumor malignancy. GO analysis revealed that co-expression genes of ARID5A are significantly involved in some important functions in glioma, and GSEA showed that multiple cancer-associated and immune-associated signaling pathways are enriched in the high ARID5A expression group. TIMER database indicated that ARID5A is correlated with tumor-infiltrating immune cells in glioma. Collectively, these findings indicate that ARID5A may be a potential prognostic biomarker and is correlated with immune infiltration in glioma.

Comprehensive analysis of a novel cuproptosis-related lncRNA signature associated with prognosis and tumor matrix features to predict immunotherapy in soft tissue carcinoma

“…Different immunological states may influence the clinical course of the same type of tumor in different ways ( Zhou et al, 2021 ). In comparison to the high-CRLncSig group patients, the low-CRLncSig group patients had better stromal, immunological, and TME cells.…”

The Prognostic Value of AT-Rich Interaction Domain (ARID) Family Members in Patients with Hepatocellular Carcinoma

“…The research found that ARID5A regulates the inflammatory process, low expression of which is correlated with poor prognosis of lung cancer patients [ 43 ]. ARID5A is also a prognostic biomarker for glioma, which is correlated with immune infiltration [ 44 ]. ARID5B is associated with histone deacetylase-1, thereby affecting cell proliferation and differentiation [ 45 ].…”

Recent Advances in the Role of Arid5a in Immune Diseases and Cancer

“…A recent study determined the diagnostic and prognostic significance of Arid5a in gliomas and discovered a possible biological function for Arid5a ( 30 ). Low grade gliomas and GBM datasets were analyzed using online database, such as TCGA, and inversely correlated high expression of Arid5a with the prognosis of all stages of gliomas.…”

“…Earlier studies reported that wild-type IDH lacks 1p/19q co-deletion and higher tumor grade was associated with poor prognosis in glioma ( 123 , 124 ). Another study reported high expression of Arid5a expression is associated with complex tumor malignancy ( 30 ), suggesting that Arid5a may be a useful marker for the degree of tumor malignancy.…”

“…Arid5a is indispensable in the development of inflammatory and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE) ( 15 ), sepsis ( 17 ), RA ( 26 ), acute lung injury (ALI) ( 27 ), as well as breast ( 20 ), lung ( 28 ), pancreatic (PDAC) ( 29 ), colorectal (CRC) ( 29 ), and brain ( 30 ) cancers. In addition, Arid5a induces chondrocyte differentiation as a transcriptional partner of Sox9 , which regulates chondrocyte differentiation through activation of Col2a1 , a chondrocyte-specific gene ( 31 ).…”