Expression and Prognostic Value of Aquaporin 1, 3 in Cervical Carcinoma in Women of Uygur Ethnicity from Xinjiang, China

Abstract

BackgroundOverexpression of several aquaporins has been reported in different types of human cancer but the role of aquaporins in carcinogenesis has not yet been clearly defined. There is few report concerning role of aquaporins in human cervical carcinogenesis so far. Here, we determined the expression and prognostic value of aquaporin 1, 3 in cervical carcinoma in Chinese women of Uygur ethnicity.Methods and ResultsReal-time PCR analyses demonstrated aquaporin 1, 3 mRNA were differentially expressed in cervical carcinoma, CIN 2-3 and mild cervicitis. Immunofluorescent and immunohistochemical analyses demonstrated aquaporin 1 was predominantly localized to stromal endothelial cells in cervical lesions. Aquaporin 3 was localized to the membrane of normal squamous epithelium, CIN and carcinoma cells. Aquaporin 1 and 3 were upregulated in cervical cancer compared to mild cervicitis and CIN2-3 (P<0.05); Tumor expression of aquaporin 1, 3 significantly increased in advanced stage disease, and patients with deeper tumor infiltration, lymph node metastases or larger tumor volume (P<0.05). Multivariate analysis demonstrated that aquaporin 1, 3 were not independent prognostic factors in cervical carcinoma.ConclusionAquaporins may participate in the initiation and progression of cervical carcinoma by promoting tumor growth, invasion or lymph node metastasis. Further study is required to determine whether aquaporins have potential as prognostic factors in cervical cancer.

Simultaneous changes of magnetic resonance diffusion-weighted imaging and pathological microstructure in locally advanced cervical cancer caused by neoadjuvant chemotherapy

“…Chen et al reported water metabolism through AQP1 and AQP3 was maintained during neoplastic transformation in human cervical carcinoma. AQP overexpression may increase tumor cells permeability to water to alter tumor cell volume and shape . Our immunohistochemical assay showed that AQP1 protein was expressed mainly in vascular endothelial cell, and also localized in the interstitial cell and cervical cancer tissues.…”

Expression of AQP1 Was Associated with Apoptosis and Survival of Patients in Gastric Adenocarcinoma

“…AQP1-expressing tumor cells have enhanced metastatic potential and increased local infiltration compared with those lacking AQP1 [6,19,20] . Knockdown of AQP1 in osteosarcoma cells can inhibit cell proliferation and significantly arrest cell cycle G1.…”

Prognostic value of several biomarkers for the patients with malignant pleural mesothelioma

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