Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma

Zhou, Xiaohui; Huang, Huimei; Cui, Wanmeng; Wang, Yifang; Luo, Wenqi; Matskova, Liudmila; Zhou, Xiaoying

doi:10.12659/msm.922836

Cited by 7 publications

(6 citation statements)

References 45 publications

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“…The scoring criteria were as previously described. [21] Prediction of miRNAs potentially targeting the CDH5 mRNA Potential miRNAs targeting the CDH5 mRNA were predicted using three publicly available programs: TargetScan (http://www.targetscan.org), Tarbase (http://carolina.imis.athena-innovation.gr) and miRBase (http://www.mirbase.org/). [22][23][24] Statistical analysis Statistical analysis was performed using the Statistical Program for Social Sciences (SPSS) 22.0 software.…”

Section: Immunohistochemistry (Ihc) Staining Assaymentioning

confidence: 99%

Inverse correlation of miR-27a-3p and CDH5 expression serves as a diagnostic biomarker of proliferation and metastasis of clear cell renal carcinoma

Wang

Zhou

Han

et al. 2021

Pathology - Research and Practice

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Section: Immunohistochemistry (Ihc) Staining Assaymentioning

confidence: 99%

Inverse correlation of miR-27a-3p and CDH5 expression serves as a diagnostic biomarker of proliferation and metastasis of clear cell renal carcinoma

Wang

Zhou

Han

et al. 2021

Pathology - Research and Practice

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“…R-cadherin expression has been found in rhabdomyosarcomas and is absent in normal myoblasts [ 24 ]. In renal cell carcinoma, the expression of CDH4 is higher than that in normal kidney tissue [ 25 ]. By analyzing the TCGA database, the results show that CDH4 is more highly expressed in cancer tissue than in normal tissue in HNSCC and OSCC.…”

Section: Discussionmentioning

confidence: 99%

CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells

et al. 2023

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Background The cadherin-4 gene (CDH4), a member of the cadherin family genes, encodes R-cadherin (R-cad); however, the function of this gene in different types of cancer remains controversial. The function of CDH4 in OSCC (oral squamous cell carcinoma) is unknown. Materials and methods We use the Cancer Genome Atlas (TCGA) database to find the expression of CDH4 in OSCC is more than normal tissue. Our tissue samples also confirmed that CDH4 gene was highly expressed in OSCC. The related cell function assay detected that CDH4 promotes the ability of cell proliferation, migration, self-renewal and invasion. Cell staining experiment confirmed that the change of CDH4 expression would change the cell mortality. The western blot of GPX4 (glutathione-dependent peroxidase-4), GSH (reduced glutathione) test assay and MDA(Malondialdehyde) test assay show that the expression of CDH4 may resist the sensitivity of ferropotosis in OSCC. Results CDH4 was upregulated in OSCC samples and was correlation with poor survival of patients. High expression of CDH4 effectively promotes the proliferation, mobility of OSCC cells and reduce the sensitivity of OSCC cells to ferroptosis. CDH4 is positively correlated with EMT pathway genes, negatively correlated with fatty acid metabolism pathway genes and peroxisome pathway genes, and positively correlated with ferroptosis suppressor genes in OSCC. Conclusions These results indicate that CDH4 may play a positive role in tumor progression and resistance ferroptosis and may be a potential therapeutic target for OSCC.

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“…More than one hundred members of the cadherin family have been identified, one of which, R-cadherin (cadherin 4, type 1), is encoded by the CDH4 gene. The R-cadherin gene has been studied mainly in relation to malignancies, and persistent associations of the risk of cancer have been reported with decreased CDH4 gene expression [ 16 , 17 ]. In contrast to healthy cells with a demethylated promoter, 57–95% of cancer cells have a methylated CDH4 promoter [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Participating in the growth and development, control of metabolism, the immune response and apoptosis and being the blood plasma enzymes, components of extracellular matrix, as well as key transcription factors, these genes are interwoven and important for the physiological and pathological aging processes. Previous reports have linked the TEAD1 , HECW1 , SEMA6A , COL13A1 and LAMA2 genes with different age-related cancers [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ], the PLAT and ACE genes with cardiovascular disease [ 22 , 23 , 24 , 25 ], the ACE and HECW1 genes with Alzheimer’s disease [ 25 , 26 ] and the SEMA6A gene with type 2 diabetes [ 27 ]. The STK38L and PKHD1L1 genes play an important role in the functioning of the immune system [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity

Erdman

Каримов

Tuktarova

et al. 2022

IJMS

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Longevity is a unique human phenomenon and a highly stable trait, characterized by polygenicity. The longevity phenotype occurs due to the ability to successfully withstand the age-related genomic instability triggered by Alu elements. The purpose of our cross-sectional study was to evaluate the combined contribution of ACE*Ya5ACE, CDH4*Yb8NBC516, COL13A1*Ya5ac1986, HECW1*Ya5NBC182, LAMA2*Ya5-MLS19, PLAT*TPA25, PKHD1L1*Yb8AC702, SEMA6A*Yb8NBC597, STK38L*Ya5ac2145 and TEAD1*Ya5ac2013 Alu elements to longevity. The study group included 2054 unrelated individuals aged from 18 to 113 years who are ethnic Tatars from Russia. We analyzed the dynamics of the allele and genotype frequencies of the studied Alu polymorphic loci in the age groups of young (18–44 years old), middle-aged (45–59 years old), elderly (60–74 years old), old seniors (75–89 years old) and long-livers (90–113 years old). Most significant changes in allele and genotype frequencies were observed between the long-livers and other groups. The search for polygenic predictors of longevity was performed using the APSampler program. Attaining longevity was associated with the combinations LAMA2*ID + CDH4*D (OR = 2.23, PBonf = 1.90 × 10−2) and CDH4*DD + LAMA2*ID + HECW1*D (OR = 4.58, PBonf = 9.00 × 10−3) among persons aged between 18 and 89 years, LAMA2*ID + CDH4*D + SEMA6A*I for individuals below 75 years of age (OR = 3.13, PBonf = 2.00 × 10−2), LAMA2*ID + HECW1*I for elderly people aged 60 and older (OR = 3.13, PBonf = 2.00 × 10−2) and CDH4*DD + LAMA2*D + HECW1*D (OR = 4.21, PBonf = 2.60 × 10−2) and CDH4*DD + LAMA2*D + ACE*I (OR = 3.68, PBonf = 1.90 × 10−2) among old seniors (75–89 years old). The key elements of combinations associated with longevity were the deletion alleles of CDH4 and LAMA2 genes. Our results point to the significance for human longevity of the Alu polymorphic loci in CDH4, LAMA2, HECW1, SEMA6A and ACE genes, involved in the integration systems.

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Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma

Cited by 7 publications

References 45 publications

Inverse correlation of miR-27a-3p and CDH5 expression serves as a diagnostic biomarker of proliferation and metastasis of clear cell renal carcinoma

Inverse correlation of miR-27a-3p and CDH5 expression serves as a diagnostic biomarker of proliferation and metastasis of clear cell renal carcinoma

CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells

Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity

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