Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas

Laimer, Klaus; Troester, Birgit; Kloss, Frank; Schäfer, Georg; Obrist, Peter; Perathoner, Alexander; Laimer, Johannes; Brandacher, Gerald; Rasse, Michael; Margreiter, Raimund; Amberger, Albert

doi:10.1016/j.oraloncology.2011.03.007

Cited by 45 publications

(33 citation statements)

References 33 publications

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“…Unfortunately, according to the recent clinical trials in ovarian cancer, melanoma, non‐small cell lung carcinoma and urothelial cancer (NCT01685255, NCT01604889, NCT02298153 at ClinicalTrials.gov), IDO1 inhibition showed unpromising data and the phase 1 and 2 trials were terminated. The present systematic review revealed that IDO1 had been studied in three articles, where only one reported weak evidence as a prognostic marker in all stages of oral cancer (Laimer et al, ). In another study (Seppälä et al, ), IDO1 was a prognostic marker only in early‐stage OTSCC.…”

Section: Discussionmentioning

confidence: 90%

The prognostic value of immune checkpoints in oral squamous cell carcinoma

et al. 2018

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Background Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC. Materials A systematic search was conducted in Ovid Medline, Scopus and Cochrane libraries, and all studies that evaluated the prognostic significance of immune checkpoints in OSCC were systematically retrieved. Results Twelve immune checkpoints/modulators were studied for their prognostic values in OSCC patients between 1985 and 2017. Seven immune checkpoints (FKBP51, B7‐H4, B7‐H6, ALHD1, PD‐L1, B7‐H3 and IDO1) were reported to be associated with poor patients’ survival in at least one study, and five (CTLA‐4, TLT‐2, VISTA, PD‐L2 and PD‐1) did not have a significant prognostic value. PD‐L1 results were controversial as it was reported to be associated with both better and worse patients’ survival. Conclusions Even though immune checkpoint markers had high expectation for OSCC prognostication, our systematic review revealed that the majority of them had been studied only once. The other molecules, which had been studied more than once, had controversial findings, except B7‐H3.

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Section: Discussionmentioning

confidence: 90%

The prognostic value of immune checkpoints in oral squamous cell carcinoma

et al. 2018

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“…IDO expression correlated with CTLA-4 expression in Tregs. Laimer et al [32] showed that IDO expression predicted shorter survival in oral squamous cell carcinoma, which suggests a potential to evaluate SLNs in these patients and treat according to IDO expression. IDO expression also correlated with FoxP3 expression, which is not surprising given IDOs known function in Treg activation [31].…”

Section: Discussionmentioning

confidence: 99%

FoxP3 and indoleamine 2,3-dioxygenase immunoreactivity in sentinel nodes from melanoma patients

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et al. 2014

American Journal of Otolaryngology

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“…It has been proposed that OSCC exhibits an immunosuppressive microenvironment [7]–[8] and tumor cells could exhibit proficient capacity to express Fas ligand to induce apoptosis of T cells [16] or to produce indoleamine 2,3-dioxygenase (IDO) to inhibit the local proliferation of effector T cells and induce the regulatory T cells [36]–[37]. We have recently demonstrated that, in OSCC, tumor nests are infiltrated by distinct subsets of CD4 + FOXP3 + regulatory T cells [23].…”

Section: Discussionmentioning

confidence: 99%

Skewed Distribution of IL-7 Receptor-α-Expressing Effector Memory CD8+ T Cells with Distinct Functional Characteristics in Oral Squamous Cell Carcinoma

et al. 2014

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CD8+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7−CD45RA−CD8+ T cells and CCR7− CD45RA+CD8+ T cells negatively correlated with each other. A significantly higher frequency of CD127lo CCR7−CD45RA−CD8+ T cells or CCR7−CD45RA+CD8+ T cells among total CD8+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127hi CCR7−CD45RA−CD8+ T cells or CCR7−CD45RA+CD8+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127lo CCR7−CD45RA−CD8+ T cells or CCR7−CD45RA+CD8+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7−CD45RA+CD8+ T cells to CCR7−CD45RA−CD8+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127lo CCR7−CD45RA−CD8+ T cells and CCR7−CD45RA+CD8+ T cells are functionally similar CD8+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8+ effector memory balance toward CCR7−CD45RA+CD8+ T cells is associated with OSCC progression.

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Expression and prognostic impact of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas

Cited by 45 publications

References 33 publications

The prognostic value of immune checkpoints in oral squamous cell carcinoma

The prognostic value of immune checkpoints in oral squamous cell carcinoma

FoxP3 and indoleamine 2,3-dioxygenase immunoreactivity in sentinel nodes from melanoma patients

Skewed Distribution of IL-7 Receptor-α-Expressing Effector Memory CD8+ T Cells with Distinct Functional Characteristics in Oral Squamous Cell Carcinoma

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