Expression and prognostic analysis of STAT6(YE361) in Hodgkin lymphoma

Yang, Liuqing; Wang, Lei; Zuo, Li-Ke; Ma, Zhiping; Yan, Shufang; Yang, Meihong; Liu, Bo; Li, Xinxia

doi:10.1016/j.prp.2022.153781

Cited by 2 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the removal of duplicates and screening of titles and abstracts, the full text of the 176 potentially qualified articles was reviewed. Finally, after excluding those with a duplicated study population (n=6), nonsurvival analysis data (n=78) and unable to obtain HR (n=50), 42 articles ( 11 , 14 – 54 ) studying 9570 patients were included in our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The reported mean or median age for studies differed widely; five studies only included patients younger than 18 years old ( 16 , 30 , 33 , 41 , 48 ), and one study only included the elderly ( 20 ). Thirty studies ( 11 , 14 , 15 , 17 , 18 , 20 – 25 , 28 – 30 , 32 – 36 , 38 , 41 , 44 – 46 , 48 – 51 , 53 , 54 ) reported the median or mean follow-up time, ranging from 25 to 130 months. In terms of methodological quality, all included studies scored more than six stars on the NOS.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-three studies ( 11 , 14 , 16 – 19 , 22 – 26 , 28 , 29 , 31 , 34 , 35 , 38 – 54 ) (corresponding to 36 sets) were included to analyze the impact of EBV infection on OS. Our meta-analysis showed that EBV positivity in HL was correlated with unfavorable outcomes for OS (HR=1.443, 95% CI: 1.250-1.666, P<0.001; Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…For the survival endpoints of OS and DSS, our results are in line with 7 studies ( 20 , 28 , 36 , 39 , 46 , 47 , 49 ), and other reports describing clinical outcomes in relation to EBV status are conflicting. Many studies have not demonstrated that EBV status has an impact on prognosis ( 35 , 38 , 40 – 42 , 44 , 45 , 51 – 54 ), whereas some studies have shown that EBV-positive status is associated with a favorable clinical outcome ( 14 , 16 , 17 , 23 , 48 , 50 ). The discrepancies observed in these studies were generally due to the heterogeneous nature of the disease and the selection bias of study subjects, age groups, EBV detection, treatment regimens and the different outcome measures used.…”

Section: Discussionmentioning

confidence: 99%

“…To date, a large number of studies have reported the correlation between Epstein−Barr virus (EBV) infection and the prognosis of HL, but the results of the studies have been inconsistent (positive, negative or no association) ( 11 , 14 – 54 ). The differences in the results of the studies may be explained by different population distributions, patient selection, statistical analysis techniques and outcome measures.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The prognostic value of Epstein−Barr virus infection in Hodgkin lymphoma: A systematic review and meta-analysis

Zhang

Tao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

IntroductionEpstein−Barr virus (EBV) contributes significantly to the development and occurrence of B-cell lymphomas. However, the association between EBV infection status and clinical outcomes in Hodgkin lymphoma (HL) patients has long been controversial. Therefore, we aimed to estimate the prognostic significance of EBV infection in HL survival.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant cohort studies from the date of their inception to February 20, 2022. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), Failure-free survival (FFS), Progression-free survival (PFS), Event-free survival (EFS) and disease-specific survival (DSS) were extracted from the studies or calculated. Subgroup analyses were conducted independently on the five survival outcomes to investigate the source of heterogeneity.ResultsA total of 42 qualified studies involving 9570 patients were identified in our meta-analysis. There was an association between EBV positivity and significantly poorer OS (HR=1.443, 95% CI: 1.250-1.666) and DSS (HR=2.312, 95% CI: 1.799-2.972). However, the presence of EBV in HL showed no effect on FFS, PFS or EFS. In subgroup analyses of OS, DSS and FFS stratified by age groups, EBV positivity was associated with poorer prognosis in elderly patients. Meanwhile, in children and adolescents with EBV-positive HL, we also observed a trend toward a better prognosis, though the results were not statistically significant.ConclusionsEBV-positive status is associated with poor OS and DSS in HL patients. EBV infection should therefore be considered a valuable prognostic marker and risk-stratifying factor in HL, especially in older patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022328708.

show abstract

Section: Resultsmentioning

confidence: 99%