Expression and possible role of fibroblast growth factor family members in porcine antral follicles during final maturation

Schams, D.; Steinberg, Vera; Šteffl, Martin; Meyer, Heinrich; Berisha, Bajram

doi:10.1530/rep-09-0033

Cited by 32 publications

(28 citation statements)

References 39 publications

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“…The abundance of FGFR mRNAs change with follicle development, for example, the abundance of FGFR2c mRNA in granulosa cells is highest in large compared to small follicles in pigs and buffalo (Evans et al 2014, Mishra et al 2016. A similar pattern has been described in theca cells in pigs (Schams et al 2009), whereas no difference was noted in cattle (Berisha et al 2004). Granulosa cell FGFR3c and FGFR4 mRNA levels were highest in large follicles in cattle (Buratini et al 2005) and buffalo (Mishra et al 2016), respectively, compared with smaller follicles.…”

Section: Receptorssupporting

confidence: 79%

“…Splice variant-specific PCR demonstrated the presence of FGFR1c, FGFR2c and FGFR3c mRNAs in granulosa and theca cells of cattle (Berisha et al 2004, Buratini et al 2005, Mishra et al 2016 and of FGFR1c and FGFR2c mRNAs in pig granulosa and theca cells (Schams et al 2009, Evans et al 2014, Furukawa et al 2014. In human ovarian samples, FGFR1c and FGFR2c mRNAs were detected but FGFR3c mRNA was not (Valve et al 2000), whereas all 'c' splice forms and FGFR4 mRNA was detected in commercially available human ovarian RNA (Cole et al 2010).…”

Section: Receptorsmentioning

confidence: 99%

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The fibroblast growth factor 8 family in the female reproductive tract

Estienne¹,

Price²

2018

Reproduction

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Several growth factor families have been shown to be involved in the function of the female reproductive tract. One subfamily of the fibroblast growth factor (FGF) superfamily, namely the FGF8 subfamily (including FGF17 and FGF18), has become important as Fgf8 has been described as an oocyte-derived factor essential for glycolysis in mouse cumulus cells and aberrant expression of FGF18 has been described in ovarian and endometrial cancers. In this review, we describe the pattern of expression of these factors in normal ovaries and uteri in rodents, ruminants and humans, as well as the expression of their receptors and intracellular negative feedback regulators. Expression of these molecules in gynaecological cancers is also reviewed. The role of FGF8 and FGF18 in ovarian and uterine function is described, and potential differences between rodents and ruminants have been highlighted especially with respect to FGF18 signalling within the ovarian follicle. Finally, we identify major questions about the reproductive biology of FGFs that remain to be answered, including (1) the physiological concentrations within the ovary and uterus, (2) which cell types within the endometrial stroma and theca layer express FGFs and (3) which receptors are activated by FGF8 subfamily members in reproductive tissues.Reproduction (2018) 155 R53-R62

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Section: Receptorssupporting

confidence: 79%

Section: Receptorsmentioning

confidence: 99%

The fibroblast growth factor 8 family in the female reproductive tract

Estienne¹,

Price²

2018

Reproduction

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“…have been found in granulosa and theca cells (Shikone et al 1992, Wandji et al 1992, Shimizu et al 2002, Schams et al 2009. In rat follicle cultures, bFGF activated primordial follicle development to the same extent as SCF (Nilsson et al 2001) and also promoted cell growth in bovine thecal and stromal cells, and is therefore thought to act in a similar fashion to SCF by regulating somatic cell growth and development (Nilsson et al 2001).…”

Section: Theca Cellsmentioning

confidence: 99%

Theca: the forgotten cell of the ovarian follicle

Young

McNeilly²

2010

Reproduction

423

292

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Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as it progresses through the developmental stages to produce a mature and fertilizable oocyte. Thecal cells are thought to be recruited from surrounding stromal tissue by factors secreted from an activated primary follicle. The precise origin and identity of these recruiting factors are currently not clear, but it appears that thecal recruitment and/or differentiation involves not just one signal, but a complex and tightly controlled combination of multiple factors. It is clear that thecal cells are fundamental for follicular growth, providing all the androgens required by the developing follicle(s) for conversion into estrogens by the granulosa cells. Their function is enabled through the establishment of a vascular system providing communication with the pituitary axis throughout the reproductive cycle, and delivering essential nutrients to these highly active cells. During development, the majority of follicles undergo atresia, and the theca cells are often the final follicular cell type to die. For those follicles that do ovulate, the theca cells then undergo hormone-dependent differentiation into luteinized thecal cells of the corpus luteum. While the theca is an essential component of follicle development and ovulation, we do not yet fully understand the control of recruitment and function of theca cells, an important consideration since their function appears to be altered in certain causes of infertility.

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“…The species has received considerable research attention in the last few years but information on certain basic aspects of buffalo reproduction is still lacking. The ovarian cycle of domestic species is characterized by repeated patterns of cellular proliferation, differentiation and transformation of ovarian steroidogenic cells (granulosa, theca and luteal cells) that accompany follicular and luteal development (Schams et al, 2009). Much like cattle, female buffalo have 2 or 3 waves of ovarian follicular development in each estrous cycle (Baruselli et al, 1997;Mondal et al, 2007).…”

Section: Introductionmentioning

confidence: 99%