Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys

Bouskila, Joseph; Burke, Mark W.; Zabouri, Nawal; Casanova, Christian; Ptito, Maurice; Bouchard, Jean‐François

doi:10.1016/j.neuroscience.2011.11.041

Cited by 40 publications

(76 citation statements)

References 61 publications

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“…Moreover, although the most abundant protein in the plasma membrane of granulosa cells was CB1, FAAH colocalized with it. This overlapping pattern in the expression of CB1 and FAAH has been reported in other cell types, such as neurons, suggesting that the endocannabinoid system might be responsible for an auto-feedback control of neurotransmitter release (38). Finally, Schuel and Burkman (39) observed that sea urchin eggs might release AEA after activation by the fertilizing sperm and this released AEA might then react with cannabinoid receptors in sperm to block acrosome reaction, thereby helping to prevent polyspermy.…”

Section: Discussionmentioning

confidence: 52%

Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation

Agirregoitia

Ibarra-Lecue

Totorikaguena

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 52%

Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation

Agirregoitia

Ibarra-Lecue

Totorikaguena

et al. 2015

Fertility and Sterility

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“…Comparative studies on the organization of the retina of different animal species led to the conclusion that ancestral mammals may have already developed cone photopigments [32]. Many components of the ECS have been localized in cone photoreceptors, horizontal, amacrine, bipolar, and retinal ganglion cells in the central and peripheral retina of vervet monkeys (Figure 1; [43]). …”

Section: The Retinal Endocannabinoid System In Monkeysmentioning

confidence: 99%

“…These receptors are differently expressed in the retina of these mammals. These results are compiled from several published articles [43,[47][48][49][50][51][52][53][54]. OS, photoreceptor outer segments; IS, photoreceptor inner segments; ONL, outer nuclear layer; ONL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer.…”

Section: Electroretinography In Monkeysmentioning

confidence: 99%

The Endocannabinoid System in the Vervet Monkey Retina

Bouskila¹,

Palmour²,

Bouchard³

et al. 2018

Primates

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The main active compound found in the marijuana plant, tetrahydrocannabinol, is responsible for its psychotropic effects but also for its numerous beneficial actions such as appetite stimulation, nausea reduction, analgesia, and muscle spasm suppressor. Although cannabis consumption leads to some visual disturbances, the exact role of the endocannabinoid system (ECS) in normal vision is still unknown. Many studies have looked into the localization of this complex system (receptors, ligands, and enzymes) throughout the various components of the visual system of different animal models in order to obtain clues about its role. In fact, the retina, optic nerve, dorsal lateral geniculate nucleus, and visual cortices all express parts of the ECS. Manipulating this system pharmacologically or genetically has also an impact on visual function. In this book chapter, we provide the current understanding of how the ECS is involved in the functioning of the visual system and special emphasis is put on data obtained in monkeys, representing the most relevant animal model for visual neuroscience research. The mechanisms that control endocannabinoid (eCB) release and activation of cannabinoid receptors are discussed. We also propose a model highlighting the mechanisms involved in the regulation of photopic and scotopic vision taking advantage of the spatial specificity of the eCB signaling system and its physiological activation conditions.

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“…In fact, Green Monkeys are used as a model organism for the study of diabetes, cardiovascular disease, HIV/AIDS, Parkinson's disease, substance abuse, attention deficit disorder, alcoholism, reproduction, tissue regeneration and other conditions [5], [7], [8], [9]. The Green Monkey has been utilized in visual neuroscience for many years [7], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], leading to a thorough anatomical description of the visual pathways and the publication of anatomical brain atlases [20], [21], [22]. Their large brain and ocular size relative to the 3.5 kg bodyweight of adult Green Monkeys is particularly advantageous in the electrophysiological study of visual abnormalities arising in the retina and optic nerve.…”

Section: Introductionmentioning

confidence: 99%

“…The retina contains several layers and different cell populations: photoreceptors, bipolar cells, ganglion cells, amacrines and horizontal cells. There is a monotonic decrease in the number of cones from the fovea centralis (containing mainly cones) to the periphery made out of rods [17], [23]. This developed fovea is well suited for high visual acuity, color vision and photopic sensitivity whereas the peripheral retina is responsible for scotopic vision (nocturnal) [24].…”

Section: Introductionmentioning

confidence: 99%

Standardized Full-Field Electroretinography in the Green Monkey (Chlorocebus sabaeus)

et al. 2014

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Full-field electroretinography is an objective measure of retinal function, serving as an important diagnostic clinical tool in ophthalmology for evaluating the integrity of the retina. Given the similarity between the anatomy and physiology of the human and Green Monkey eyes, this species has increasingly become a favorable non-human primate model for assessing ocular defects in humans. To test this model, we obtained full-field electroretinographic recordings (ERG) and normal values for standard responses required by the International Society for Clinical Electrophysiology of Vision (ISCEV). Photopic and scotopic ERG recordings were obtained by full-field stimulation over a range of 6 log units of intensity in dark-adapted or light-adapted eyes of adult Green Monkeys (Chlorocebus sabaeus). Intensity, duration, and interval of light stimuli were varied separately. Reproducible values of amplitude and latency were obtained for the a- and b-waves, under well-controlled adaptation and stimulus conditions; the i-wave was also easily identifiable and separated from the a-b-wave complex in the photopic ERG. The recordings obtained in the healthy Green Monkey matched very well with those in humans and other non-human primate species (Macaca mulatta and Macaca fascicularis). These results validate the Green Monkey as an excellent non-human primate model, with potential to serve for testing retinal function following various manipulations such as visual deprivation or drug evaluation.

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Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys

Cited by 40 publications

References 61 publications

Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation

Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation

The Endocannabinoid System in the Vervet Monkey Retina

Standardized Full-Field Electroretinography in the Green Monkey (Chlorocebus sabaeus)

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