Abstract:Copper is an essential micronutrient as its redox properties play a significant biochemistry role in the nervous system. Its essentiality is evidenced by Menkes disease (MD), an X-linked neurodegenerative disease caused by mutations in the ATP7A copper transporter, showing that ATP7A is concerned with the development of the nervous system. To investigate the regulation of ATP7A in the development of neurons, we analyzed the expression of the mRNA, protein and the localization of ATP7A in C57BL/6 mice neural st… Show more
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