Expression and localization of the vascular endothelial growth factor and changes of microvessel density during hair follicle development of Liaoning cashmere goats

Zhang, Q L; Li, J P; Li, Y M; Chang, Qing; Chen, Y; Jiang, Honglei; Zhao, Zhe‐Ming; Guo, Ding-Jiong

doi:10.4238/2013.december.10.3

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…In the present study, no statistically significant variations were observed in the population of secondary hair follicles in the skin of cashmere goats across different age groups, as indicated by SFDI, SFN, and S:P. This finding further validates the precision of the slicing technique in this study and establishes a solid foundation for quantitative assessment of active secondary hair follicles. The activity of secondary hair follicles in the skin of cashmere goats has been confirmed to peak during the months of August and September [11,12,30]. The activity of secondary hair follicles in the skin of one-year-old Inner Mongolian cashmere goats as well as Liaoning cashmere goats was reported to be 81% [11], 69% [12], and 70% [13], respectively.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Variations in the Population of Active Secondary Hair Follicles, Oxidative Stress and Antioxidant Parameters in Cashmere Goats

Li,

Wang,

Wang

et al. 2024

Animals

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The objective of this study was to investigate age-related changes in cashmere production and the population of active secondary hair follicles in cashmere goats across different age groups as well as to explore the association between secondary hair follicle activity and oxidative stress. A total of 104 adult Inner Mongolian ewe goats, aged between 2 and 7 years old, were randomly selected as experimental subjects. Skin samples were collected in August 2020 and cashmere samples were collected in April 2021. The cashmere fiber yield, staple length, and diameter showed age-related variations in cashmere goats aged 2 to 7 years (p < 0.05). Cashmere production was higher in goats aged 2–4 years compared to those aged 5–7 years (p < 0.05). There were no significant differences in the population of primary and secondary hair follicles among goats aged 2 to 7 years. However, the population of active secondary hair follicles varied significantly with age, with the younger group (aged 2–4 years) having a higher population than those aged 5–7 years (p < 0.05). A moderate negative correlation was observed between cashmere fiber diameter and the population of active secondary hair follicles (p < 0.05). Age-related variations in skin antioxidant capacity and oxidative damage were observed among cashmere goats aged 2 to 7 years old (p < 0.05). Goats aged 2 to 4 years exhibited higher antioxidant capacity and lower oxidative damage (p < 0.05). Interestingly, the skin’s antioxidant capacity and oxidative damage exhibited significant positive and negative correlations with the population of active secondary hair follicles (p < 0.05). This study presents a novel approach to enhance the activity of secondary hair follicles and improve cashmere production performance through the regulation of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Age-Related Variations in the Population of Active Secondary Hair Follicles, Oxidative Stress and Antioxidant Parameters in Cashmere Goats

Li,

Wang,

Wang

et al. 2024

Animals

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“…Exogenous VEGF dose-dependently stimulates cell proliferation, which is mediated by vascular endothelial growth factor receptor 2 (VEGFR-2) through phosphorylation of extracellular signal-regulated kinase (ERK) in human outer root sheath cells and human hair follicle dermal papilla cells (Li et al, 2012a; Magnuson et al, 2012). And VEGF expression in secondary hair follicles than it did in primary hair follicles (Zhang et al, 2013). The VEGF accelerates hair growth in mice and humans, but its function has not been determined in goat.…”

Section: Introductionmentioning

confidence: 92%

Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse

Wenlei¹,

Yin²,

Liang³

et al. 2014

Asian Australas. J. Anim. Sci

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To detect goat vascular endothelial growth factor (VEGF)-mediated regrowth of hair, full-length VEGF164 cDNA was cloned from Inner Mongolia cashmere goat (Capra hircus) into the pET-his prokaryotic expression vector, and the recombinant plasmid was transferred into E. coli BL21 cells. The expression of recombinant 6×his-gVEGF164 protein was induced by 0.5 mM isopropyl thio-β-D-galactoside at 32°C. Recombinant goat VEGF164 (rgVEGF164) was purified and identi ed by western blot using monoclonal anti-his and anti-VEGF antibodies. The rgVEGF164 was smeared onto the dorsal area of a shaved mouse, and we noted that hair regrowth in this area was faster than in the control group. Thus, rgVEGF164 increases hair growth in mice.

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Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway

Fan

Tian

et al. 2016

Biomedicine & Pharmacotherapy

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Expression and localization of the vascular endothelial growth factor and changes of microvessel density during hair follicle development of Liaoning cashmere goats

Cited by 4 publications

References 31 publications

Age-Related Variations in the Population of Active Secondary Hair Follicles, Oxidative Stress and Antioxidant Parameters in Cashmere Goats

Age-Related Variations in the Population of Active Secondary Hair Follicles, Oxidative Stress and Antioxidant Parameters in Cashmere Goats

Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse

Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway

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