Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro

Gruber, Helen E.; Yamaguchi, Dean T.; Ingram, Jane A.; Leslie, Kelly; Huang, Wenliang; Miller, Timothy A.; Hanley, Edward N.

doi:10.1186/1471-2474-3-4

Cited by 49 publications

(46 citation statements)

References 22 publications

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“…Estrogen deficiency in menopause is associated with certain changes. The intervetebral disc annulus fibrosis cells have been shown to express the estrogen beta receptor gene and culture of these cells in estradiol showed significantly increased cellular proliferation (Gruber et al, 2002). The flattening of the intervertebral discs contributes to the height loss associated with menopause.…”

Section: Discussionmentioning

confidence: 99%

“…Vertebral fractures resulting from osteoporosis also leads to loss of vertebral body height and in other instances kyphosis which in turn causes a decrease in stature. Consequently, excessive decrease in height in postmenopausal women is highly suggestive of the presence of osteoporotic fractures and should serve as an indication for a spinal radiograph (Kaptoge et al, 2004;Gunnes et al, 1996;Spector et al, 1993;Riggs and Melton, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…A previous study indicated that measurement of height loss could be an accurate method for detecting vertebral fractures . The thresholds useful in clinical practice to detect prevalent vertebral fracture range from 3 cm to 6 cm, with the risk of prevalent fracture increasing with the magnitude of the height loss (Krege et al, 2006;Vokes et al, 2006;Gunnes et al, 1996). A mean loss of height of 4.5 cm since early adulthood was observed in the study by Briot et al (2010) in a large population of postmenopausal women in primary care practices.…”

Section: Introductionmentioning

confidence: 97%

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Evaluation of the height of premenopausal and postmenopausal women in Zaria, Nigeria

Achie¹,

Olorunshola²,

Mabrouk³

2014

J. Physiol. Pathophysiol.

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Excessive height loss in postmenopausal women (PMW) has been found to reflect low bone mass; an index helpful in predicting vertebral fractures. One hundred and sixty five women were recruited for the cross-sectional study comprising of 77 premenopausal women who served as control and 88 PMW who constituted the study group. The subjects were administered a questionnaire after obtaining informed consent. While their height, weight, waist circumference and serum testosterone levels were determined utilizing standard methods. The results were presented as mean ± SD, while data was analyzed with Student's t-test, one way ANOVA, and correlation for comparing association; p<0.05 was considered significant. The postmenopausal women had a significantly lower mean height (158.56 ± 7.02 cm) than the premenopausal women (162.25 ± 6.44 cm), p<0.001. There was a decrease in mean postmenopausal height with increasing duration of menopause, however, it was not statistically significant; 158.71 ± 7.32, 158.40 ± 7.34 and 158.41 ± 6.41 cm, respectively for women who were 1-5, 6 -10 and > 10 years postmenopausal. The age at menopause and the body mass index demonstrated a positive correlation with the height of the menopausal women. While the serum testosterone and the body mass of the postmenopausal women demonstrated a negative correlation with their age at menopause. It is concluded that the postmenopausal women had a significantly lower height than the premenopausal women (mean height difference of 3.69 cm) and were at risk of vertebral fractures; critical levels predictive for vertebral fractures range between 3 -6 cm losses in height. We recommend longitudinal studies to determine the prospective height loss across the menopause transition in Nigerian women and thus indicate the critical levels predictive for vertebral fractures for Nigerian menopausal women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Evaluation of the height of premenopausal and postmenopausal women in Zaria, Nigeria

Achie¹,

Olorunshola²,

Mabrouk³

2014

J. Physiol. Pathophysiol.

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“…Exposing anulus cells to 17-β-estradiol led to significantly greater proliferation than in low serum controls. The effect of estrogen on the disc cells could be related to the anti-apoptotic effect of IGF-1 on them (Gruber et al, 2002).…”

Section: The Molecular Biology Of Anulus Fibrosus Components and Theimentioning

confidence: 99%

Molecular Biology and Interactions in Intervertebral Disc Development, Homeostasis, and Degeneration, with Emphasis on Future Therapies: A Systematic Review

Aker¹,

Ghannam²,

Alzuabi³

et al. 2017

The Spine Scholar

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The unique properties of the intervertebral disc (IVD) are evident in its structural complexity and functional importance for spinal support and stability. The contributions of the different cellular and extracellular components to the function of the IVD depend on their distinctive molecular features and pathways. Disruption of these molecular pathways influences the pathological changes involved in IVD degeneration. Therefore, the molecular features of the IVD have been the focus of interest for many researchers seeking to elucidate its normal functioning, potential pathologies, and appropriate therapies. The aim of the present article is to review the molecular aspects of IVD development, specific cellular markers, and the interactions between cellular and extracellular components responsible for homeostasis, degeneration and potential therapies. The literature available via PubMed and Google Scholar was reviewed and the relevant references in review articles were searched manually. Spine

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“…The sample size used in this superiority trial was calculated on a difference in effect size of ϳ0.4 SD units between hylan and HA, derived from a meta-analysis performed in 2003 (2). However, several meta-analyses, including new controlled trials and comparison studies between viscosupplements (with conflicting results), have been published since 2003 (3)(4)(5). A recent trial (not supported by a pharmaceutical firm) demonstrated superiority of hylan compared with HA (notably in terms of duration of action) but without a huge difference in terms of the magnitude of response (5).…”

Section: To the Editormentioning

confidence: 99%

Intervertebral disc is an alternate tissue source of circulating C‐telopeptide of type II collagen after menopause or ovariectomy: Comment on the article by Sondergaard et al

Cake

Melrose

2008

Arthritis & Rheumatism

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Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro

Cited by 49 publications

References 22 publications

Evaluation of the height of premenopausal and postmenopausal women in Zaria, Nigeria

Evaluation of the height of premenopausal and postmenopausal women in Zaria, Nigeria

Molecular Biology and Interactions in Intervertebral Disc Development, Homeostasis, and Degeneration, with Emphasis on Future Therapies: A Systematic Review

Intervertebral disc is an alternate tissue source of circulating C‐telopeptide of type II collagen after menopause or ovariectomy: Comment on the article by Sondergaard et al

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