“…Instead, two external blockers of these K + channels in arterial SM, anandamide 10 µmol/L [ 114 ] and zinc ion (Zn +2 ) 100 µmol/L [ 114 , 116 ], and two openers, halothane [ 114 ] and ONO-RS-082 [ 117 ], have been reported. Moreover, these channels are sensitive to important biophysical stimuli (e.g., pH, temperature, and mechanical pressure), and some of them are inhibited by the acidification of extracellular fluid [ 1 , 100 , 116 , 118 ]. The K 2P channels are also targets for drugs (including inhalational and local anesthetics, antipsychotics, antidepressants, and neuroprotective agents), and modulated by G protein signaling pathways and second messengers [ 103 , 104 , 106 , 107 , 119 , 120 ].…”