Expression and functional analysis of mussel taurine transporter, as a key molecule in cellular osmoconforming

Hosoi, Masatomi; Takeuchi, Keigo; Sawada, Hideki; Toyohara, Haruhiko

doi:10.1242/jeb.01868

Cited by 38 publications

(56 citation statements)

References 43 publications

(53 reference statements)

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“…By interfering with the epithelial absorption of the nutrient, these substances can be classified as anti-nutritional factors. TauT was described in mammals (Bedford et al, 2000), chicken (Kim et al, 2006), common carp and tilapia (Takeuchi and Toyohara, 2000), S. senegalensis (Pinto et al, 2011), and mussels (Hosoi et al, 2005); hence it is likely that such anti-nutritional action of substances such as β-amino acids would be conserved in fish. Results suggest an interaction between taurine and other anti-nutritional factors, as illustrated by the restorative effects of cholyltaurine on saponin-and lectin-induced enteritis Iwashita et al, 2009).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Taurine: a critical nutrient for future fish feeds

2015

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Taurine is a sulfonic acid found in high concentrations in animal tissues. In recent years, a number of studies have demonstrated the essentiality of dietary taurine for many commercially relevant species, especially marine teleosts. Consequently, the removal of taurine-rich dietary ingredients such as fishmeal may create a deficiency, of which symptoms include reduced growth and survival, increased susceptibility to diseases, and impaired larval development. These symptoms emphasize the systemic role of taurine in the animal's physiology and provide few clues as to the underlying mechanisms of taurine function. In fact, a myriad of roles have been attributed to taurine in mammals, ranging from bile salt conjugation to membrane stabilization, osmoregulation, anti-oxidation, immunomodulation, calcium-signaling, and neuroprotection. This review describes the current knowledge of taurine physiology and metabolism in fish and requirement levels in relevant species, and highlights possible parallels with mammalian taurine metabolism. In addition, the effects of ingredient processing and feed manufacturing on taurine bioavailability are discussed. Finally, regulatory aspects are brought to the forefront: although the supplementation of taurine will be necessary to further reduce the use of ingredients such as fishmeal, taurine is not currently approved by the FDA in the USA for fish feeds.Obtaining approval in the United States to utilize taurine in fish feeds can improve the environmental and economic sustainability of fish feeds nation-wide.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Taurine: a critical nutrient for future fish feeds

2015

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“…However, recent studies have confirmed that taurine has a wide variety of biological functions including maintaining homeostasis and regulating physiological functions of different systems. Taurine also possesses a wide spectrum of pharmacological activities such as antipyretic, anticonvulsant, antiplatelet-aggregation, hypotensive, immunity-enhancing, liver-protecting and angiotasisregulating effects [10][11][12][13][14][15][16][17] . It is known that the liver is the main www.wjgnet.com organ for taurine biosynthesis and also an important target organ for taurine's many biological activities.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis

Liang¹,

Deng²,

Lin³

et al. 2009

WJG

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AIM:To investigate the inhibitory effect of natural taurine (NTau) on portal hypertension (PHT) in rats with experimentally-induced liver cirrhosis (LC). METHODS:Experimentally-induced LC Wistar rats (20 rats/group) were treated with either oral saline or oral NTau for 6 consecutive weeks. Evaluation parameters included portal venous pressure (PVP), portal venous resistance (PVR), portal venous flow (PVF), splanchnic vascular resistance (SVR) and mean arterial pressure (MAP). Vasoactive substance levels including nitric oxide (NO), nitric oxide synthase (NOS) and cyclic guanosine monophosphate (cGMP) were also measured. Histological investigation of type Ⅰ and Ⅲ collagen (COL Ⅰ and Ⅲ) and transforming growth factor-β1 (TGF-β1) was also performed. RESULTS:

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“…It is important to note, however, that the presence of free taurine (or other amino acids) in neurons is not, in and of itself, evidence for its being a neurotransmitter. Taurine is an important osmoregulator in many vertebrates (Schaffer et al 2000;Warskulat et al 2004) and invertebrates (Yin et al 2000;Hosoi et al 2005) and it and b-alanine have been implicated as osmoregulators in cnidarians (Walther 2002). Its presence in cnidarian neurons is, therefore, not altogether unexpected.…”

Section: Discussionmentioning

confidence: 99%

Physiological and chemical analysis of neurotransmitter candidates at a fast excitatory synapse in the jellyfish Cyanea capillata (Cnidaria, Scyphozoa)

Anderson

Trapido-Rosenthal

2009

Invert Neurosci

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Motor nerve net (MNN) neurons in the jellyfish Cyanea capillata communicate with one another by way of fast, bidirectional excitatory chemical synapses. As is the case with almost all identified chemical synapses in cnidarians, the identity of the neurotransmitter at these synapses is unclear. MNN neurons are large enough for stable intracellular recordings. This, together with the fact that they can be exposed, providing unlimited access to them and to their synapses, prompted a study of the action of a variety of neurotransmitter candidates, including those typically associated with fast synapses in higher animals. Only the amino acids taurine and beta-alanine produced physiological responses consistent with those of the normal EPSP in these cells. Moreover, chemical analysis revealed that both taurine and beta-alanine are present in the neurons and released by depolarization. These various findings strongly suggest that either or both of these amino acids, or a closely related compound is the neurotransmitter at the fast chemical synapses between MNN neurons.

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Expression and functional analysis of mussel taurine transporter, as a key molecule in cellular osmoconforming

Abstract: intensive expression of muTAUT was observed in the gill and epithelium of the mantle, which were directly exposed to intensive osmotic changes of ambient seawater.

Cited by 38 publications

References 43 publications

Taurine: a critical nutrient for future fish feeds

Taurine: a critical nutrient for future fish feeds

Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis

Physiological and chemical analysis of neurotransmitter candidates at a fast excitatory synapse in the jellyfish Cyanea capillata (Cnidaria, Scyphozoa)

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