Expression and function of PIM kinases in osteosarcoma

Mou, Shuai; Wang, Guangbin; Ding, Ding; Yu, Dongdong; Pei, Yi; Teng, Songling; Fu, Qin

doi:10.3892/ijo.2016.3708

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Furthermore, patients with high PIM1 expression had a poorer OS compared with patients with low PIM1 expression. Our findings are similar to those of Shuai [72] , Guo [73] , and His [74] reporting different kinds of carcinomas, suggesting that PIM1 may act as a prognostic factor for PCNSL patients.…”

Section: Discussionsupporting

confidence: 89%

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Zhou

Liu

et al. 2018

Neoplasia

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Primary central nervous system lymphoma (PCNSL) is a rare and special type of non-Hodgkin lymphoma. The treatment of PCNSL is comprehensive, combining surgery, radiotherapy, and chemotherapy. However, the outcome is poor because of its high invasiveness and rate of recurrence. We analyzed 22 cases of PCNSL using next-generation sequencing (NGS) to detect 64 candidate genes. We used immunohistochemical methods to analyze gene expression in 57 PCNSL samples. NGS showed that recurrent mutations in KMT2D and CD79B, components of the NF-κB pathway, accounted for 65% of total mutations in PCNSL samples. The most frequent mutated gene was PIM1 (77.27%, 17/22), followed by MYD88 (63.64%, 14/22), CD79B (69.09%, 13/22), and KMT2D (50.00%, 11/22). Mutations of the CD79B gene were associated with an inferior progression-free survival (PFS), and GNA13 gene mutations were associated with a shorter PFS and overall survival (OS) in PCNSL patients (P < .05). PIM1 and MYD88 were highly expressed in PCNSL patients and were related to their OS time. MYD88 overexpression might be an independent and poor prognostic predictor of OS time. In summary, we identified highly recurrent genetic lesions in CD79B and KMT2D, components of the NF-κB pathway, in PCNSL and validated the expression of PIM1 and MYD88 related to poor survival, thereby providing novel insights into the pathogenesis and precision medicine of PCNSL.

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Section: Discussionsupporting

confidence: 89%

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Zhou

Liu

et al. 2018

Neoplasia

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“…When we consider the link between transcriptional changes and sperm phenotypic effects, the higher expression levels of PIM1 appear to be consistent with our earlier findings of longer and faster swimming sperm in BY (Yang, Zhang, Wang, Yang, et al, 2020; Yang, Zhang, Wang, Zhang, et al, 2020). The relationship between the expression level of PIM1 and sperm trait variation has yet been explored, nonetheless, several studies have shown that PIM1 can accelerate cancer cell motility and the overexpression of PIM1 results in increased cancer cell motility (Mou et al, 2016; Santio et al, 2020; Tanaka et al, 2009). PIM1 kinase accelerates cell motility by phosphorylating and activating target proteins.…”

Section: Discussionmentioning

confidence: 99%

Duplicate genes as sources for rapid adaptive evolution of sperm under environmental pollution in tree sparrow

et al. 2023

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Environmental pollution can result in poor sperm quality either directly or indirectly in birds. However, adaptive and compensatory sperm morphology changes and motility improvements have rapidly evolved in tree sparrows (Passer montanus) inhabiting polluted areas over the past 65 years. To identify the genetic underpinnings of the rapidly evolving sperm phenotype, we carried out population genomics and transcriptomics on tree sparrow populations in the two differently polluted places. We identified a gene encoding the serine/threonine protein kinase PIM1, which may drive rapid phenotypic evolution of sperm. An unprecedented and remarkable expansion of the PIM gene family, caused by tandem and segmental duplication of PIM1, was subsequently observed in the tree sparrow genome. Most PIM1 duplicates showed a testis-specific expression pattern, suggesting that their functions are related to male reproduction. Furthermore, the elevated expression level of PIM1 was consistent with our earlier findings of longer and faster swimming sperm in polluted sites, indicating an important role for duplicated PIM1 in facilitating the rapid evolution of sperm. Our results suggest that duplicated PIM1 provides sources of genetic variation that may enable the rapid evolution of sperm under environmental heavy metal pollution. The findings of this study indicated that duplicated genes can be targets of selection and predominant sources for rapid adaptation to environmental change and shed light on sperm evolution under pollution stress.

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“…However, clinical significance of Pim-1 has not been widely recognized and is somewhat controversial in different tumors. Studies have shown that the expression of Pim-1 is negatively correlated with the prognosis of leukemia, 26 lymphoma, 27 head and neck tumors, 28 - 30 osteosarcoma, 31 - 33 gallbladder cancer, 34 colorectal cancer, 35 , 36 and non-small cell lung cancer (NSCLC). 37 Nevertheless, Reiser-Erkan et al 38 showed that Pim-1 kinase overexpression in pancreatic cancer had a good prognosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Pim-1 in Human Cancers: A Meta-analysis of Association with Prognosis and Clinicopathological Characteristics

et al. 2022

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Background Pim-1 is overexpressed in cancer tissues and plays a vital role in carcinogenesis. However, its clinical significance in cancers is not fully verified by meta-analysis, especially in relation to prognosis and clinicopathological features. Methods Four databases, PubMed, Embase, Cochrane Library, and Web of Science, were searched. Literature screening and data extraction according to the inclusion and exclusion criteria. The quality of the included literatures was evaluated using the Newcastle-Ottawa scale and the data analysis was performed using STATA and Review Manager software. Results 15 articles were finally included for meta-analysis, involving 1651 patients. Effect-size pooling analysis showed that high Pim-1 was related to poor overall survival (OS) (HR 1.68 [95% CI 1.17-2.40], P = .004) and disease-free survival (DFS) (HR 2.15 [95 %CI 1.15-4.01], P = .000). Subgroup analysis indicated that the detection techniques of Pim-1 were the main sources of heterogeneity, and 2 literatures using quantitative polymerase chain reaction (qPCR) for Pim-1mRNA had high homogeneity (I2 = .0%, P = .321) in OS. Another 13 studies that applied immunohistochemistry (IHC) for Pim-1 protein had significant heterogeneity (I2=82.2%, P = .000; I2=92%, P = .000) in OS and DFS, respectively, and further analysis demonstrated that ethnicity, sample size, and histopathological origin were considered to be the main factors affecting their heterogeneity. In addition, high Pim-1 was associated with lymph node metastasis (OR 1.40 [95% CI 1.02-1.92], P = .04), distant metastasis (OR 2.69 [95%CI 1.67-4.35], P < .0001), and clinical stage III-IV (OR .7 [95% CI .50-.96, P = .03). Sensitivity analysis suggested that the pooled results of each effect-size were stable and reliable, and there was no significant publication bias ( P = .138) in all included articles. Conclusion High Pim-1 can not only predict poor OS and DFS of cancer, but also help to infer the malignant clinical characteristics of tumor metastasis. Pim-1 may be a potential and promising biomarker for early diagnosis, prognostic analysis and targeted therapy of tumors.

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Expression and function of PIM kinases in osteosarcoma

Cited by 9 publications

References 54 publications

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Duplicate genes as sources for rapid adaptive evolution of sperm under environmental pollution in tree sparrow

Clinical Significance of Pim-1 in Human Cancers: A Meta-analysis of Association with Prognosis and Clinicopathological Characteristics

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