Expression and function of interleukin-8 in human hepatocellular carcinoma

Akiba, Jun; Yano, Hirohisa; Ogasawara, Satoshi; Higaki, Koichi; Kojiro, Masamichi

doi:10.3892/ijo.18.2.257

Cited by 66 publications

(73 citation statements)

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“…10,11 Moreover, CXCL8 protein was detected immunohistochemically in hepatoma tissues. 12,38,39 However, we could not detect CXCR1 and CXCR2 mRNA in any hepatoma cell lines under our present experiment conditions. CXCL8 is a potent angiogenic factor and hepatoma tissue is characterized by abundant neovascularization.…”

Section: Discussioncontrasting

confidence: 41%

Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas

Nakamoto

Nemoto-Sasaki

et al. 2003

The American Journal of Pathology

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Hepatoma cell lines can produce a massive amount of chemokines in response to various stimuli including hepatitis viruses and their products. However, it remains elusive on the types of chemokine receptor(s) expressed in the hepatoma tissues and its roles in hepatoma development. To clarify these points, we examined the chemokine receptor expression in six human hepatoma cell lines. All of the hepatoma cell lines constitutively and exclusively expressed CCR1 mRNA and its protein on their cell surface. CCR1 expression was also detected on hepatoma cells and to a lesser degree, on endothelial cells in hepatoma tissues but not in normal liver tissues. Furthermore, CCL3 expression was detected in hepatoma cells, endothelial cells, and to a lesser degree, fibroblast-like cells in hepatoma tissue, whereas only occasional vascular endothelial cells and inflammatory cells in normal liver tissues were weakly positive for CCL3. Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional.

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Section: Discussioncontrasting

confidence: 41%

Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas

Nakamoto

Nemoto-Sasaki

et al. 2003

The American Journal of Pathology

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“…Studies also show that necrotic cells can induce inflammation characterized by increased production of KC/MIP-2 and infiltrating neutrophils (36), indicating necrotic foci seen in GSD-Ia mouse liver could pose additional risk of hepatic injury. The increases in CXC chemokines along with elevated infiltrating neutrophils have been shown to associate with many liver injuries, including alcoholic liver disease and hepatocellular carcinoma (33,34,(37)(38)(39)(40)(41). Necrosis seen in mouse GSD-Ia livers that also accumulate excessive glycogen and fat suggest that neutrophil-mediated liver injuries may predispose GSD-Ia patients to develop HCA.…”

Section: Discussionmentioning

confidence: 99%

Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Kim

Weinstein

Starost

et al. 2008

Journal of Hepatology

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Background/Aims-Glycogen storage disease type Ia (GSD-Ia) patients manifest the long-term complication of hepatocellular adenoma (HCA) of unknown etiology. We showed previously that GSD-Ia mice exhibit neutrophilia and elevated serum cytokine levels. This study was conducted to evaluate whether human GSD-Ia patients exhibit analogous increases and whether in GSD-Ia mice a correlation exists between immune abnormalities and, biochemical and histological alterations in the liver.Methods-Differential leukocyte counts and cytokine levels were investigated in GSD-Ia patients. Hepatic chemokine production, neutrophil infiltration, and histological abnormalities were investigated in GSD-Ia mice.Results-We show that GSD-Ia patients exhibit increased peripheral neutrophil counts and serum interleukin-8 (IL-8). Compared to normal subjects, HCA-bearing GSD-Ia patients have a 2.8-fold higher serum IL8 concentration, while GSD-Ia patients without HCA have a 1.4-fold higher concentration. Hepatic injury in GSD-Ia mice is evidenced by necrotic foci, markedly elevated infiltrating neutrophils, and increased hepatic production of chemokines.Conclusion-Peripheral neutrophilia and elevated serum chemokines are characteristic of GSDIa with HCA-bearing GSD-Ia patients having the highest serum IL-8. In GSD-Ia mice these elevations correlate with elevated hepatic chemokine levels, neutrophil infiltration, and necrosis. Taken together, peripheral neutrophilia and increased serum chemokines may indicate hepatic injuries in GSD-Ia

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“…Similarly, other Th1 cytokines like IFNγ, IL8, IL15, and IL18 have been indicated to correlate with invasiveness and metastasis during HCC [60] . Alterations in these cytokines may help to control or ameliorate carcinogenesis, as they are capable of changing the functional status of cells like NK cells and cytotoxic T lymphocytes [61] .…”

Section: Th1 and Th2 Cytokinesmentioning

confidence: 99%

Immunology of hepatocellular carcinoma

Sachdeva

Chawla

Arora

2015

WJH

100

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Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells (e.g. , dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC.

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Expression and function of interleukin-8 in human hepatocellular carcinoma

Cited by 66 publications

References 0 publications

Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas

Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas

Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Immunology of hepatocellular carcinoma

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