Expression and function of FGF10 in mammalian inner ear development

Pauley, Sarah; Wright, Tracy J.; Pirvola, Ulla; Ornitz, David M.; Beisel, Kirk W.; Fritzsch, Bernd

doi:10.1002/dvdy.10297

Cited by 216 publications

(339 citation statements)

References 55 publications

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“…Sections were incubated with 10 6 cpm of [ 33 P]-labeled antisense riboprobe prepared using the following linearized plasmid templates and RNA polymerases: (1) GATA-4, BamHI digested pBluescript SK phagemid G14a (Arceci et al, 1993), T7 polymerase; (2) Shh, HindIII-digested pBluescript SK plasmid containing the cDNA, T3 polymerase (Bitgood and McMahon, 1995); (3) FGF-10, 584 nucleotide cDNA fragment, BamHI digested pBluescript KS II, T3 polymerase (Pauley et al, 2003). Scion™ imaging software was used to quantify the relative expression levels in proximal versus distal for each of the transcripts.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

Jacobsen¹,

Mannisto²,

Porter-Tinge³

et al. 2005

Developmental Dynamics

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Transcription factor GATA-4 is a key participant in cytodifferentiation of the mouse hindstomach. Here we show that GATA-4 cooperates with a Friend-of-GATA (FOG) cofactor to direct gene expression in this segment of gut. Immunohistochemical staining revealed that GATA-4 and FOG-1 are co-expressed in hindstomach epithelial cells from embryonic days (E) 11.5 to 18.5. The other member of the mammalian FOG family, FOG-2, was not detected in gastric epithelium. To show that GATA-4:FOG interactions influence stomach development, we analyzed Gata4 ki/ki mice, which express a mutant GATA-4 that cannot bind FOG cofactors. Sonic Hedgehog, an endoderm-derived signaling molecule normally down-regulated in the distal stomach, was over-expressed in hindstomach epithelium of E11.5 Gata4 ki/ki mice, and there was a concomitant decrease in fibroblast growth factor-10 in adjacent mesenchyme. We conclude that functional interaction between GATA-4 and a member of the FOG family, presumably FOG-1, is required for proper epithelial-mesenchymal signaling in the developing stomach. Developmental Dynamics 234:355-362, 2005.

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Section: In Situ Hybridizationmentioning

confidence: 99%

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

Jacobsen¹,

Mannisto²,

Porter-Tinge³

et al. 2005

Developmental Dynamics

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show abstract

“…) results in absence of all three semicircular canals and the posterior crista. The anterior crista is malformed and misaligned relative to the utricle (Pauley et al 2003).…”

Section: Non-notch Pathwaymentioning

confidence: 99%

“…So far, a majority of the phenotypes reported for Fgf10 knockout mice are consistent with Fgf10's postulated role in mediating nonsensory tissue development. However, the associated sensory phenotypes observed in Fgf10 knockout mice suggest that other FGF receptors besides FGFR-2 (IIIb) are responsible for mediating this development (Pauley et al 2003).…”

Section: Relationship Of Sensory and Nonsensory Tissue Developmentmentioning

confidence: 99%

Molecular Genetics of Vestibular Organ Development

Chang¹,

Cole²,

Cantos³

et al. 2004

The Vestibular System

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“…At early stages of embryogenesis, Fgfr1, Fgfr2, and several FGFs, including FGF3, FGF8, FGF10, and FGF19, are critical for either the induction of the otic vesicle or the initial development of the sensory epithelium (Mansour et al, 1993;Ladher et al, 2000Ladher et al, , 2005Pirvola et al, 2000Pirvola et al, , 2002Phillips et al, 2001Phillips et al, , 2004Pauley et al, 2003;. At intermediate stages of development, FGF signaling is also important; tissuespecific deletion of Fgfr1 results in severe defects in the development of the auditory sensory epithelium apparently due to a severe reduction in the precursor cells that give rise to the organ of Corti.…”

Section: Introductionmentioning

confidence: 99%