Expression and function of beta1 integrins on human eosinophils

Seminario, Maria Cristina; Bochner, Bruce S.

doi:10.1590/s0074-02761997000800021

Cited by 22 publications

(15 citation statements)

References 69 publications

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“…Their expression is increased by IL-4 and IL-13 [91]. Omalizumab has been found to affect the production of these cytokines [8,9,37], thus it can potentially also influence eosinophil diapedesis.…”

Section: Mechanisms Of Omalizumab Effect On Eosinophilsmentioning

confidence: 99%

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

Kupryś‐Lipińska¹,

Molińska²,

Kuna³

2016

Advances in Respiratory Medicine

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Bronchial asthma is characterised by high levels of immunoglobulin E (IgE) and overproduction of pro-inflammatory cytokines, including interleukins IL-4, IL-13 and IL-5 needed for, amongst other things, the production of IgE and the differentiation, maturation, migration and survival of eosinophils. Eosinophils are one of the most important cells in allergic inflammation. Their presence in tissue is linked to the persistence of inflammatory infiltrate, tissue damage and remodelling. Although these cells are very sensitive to corticosteroids, some asthmatic patients do not respond to high doses of these drugs, even when administered systemically. Transbronchial biopsies and bronchoalveolar lavage performed in patients with steroid-resistant asthma have demonstrated higher levels of eosinophils and Th2-type cytokines (IL-4 and IL-5) compared to steroid-sensitive patients. Clinical studies have confirmed that the very effective treatment in these cases is therapy with omalizumab -an anti-IgE monoclonal antibody. The paper discusses the efficacy of omalizumab in reducing eosinophil number in peripheral blood and in the airways of asthmatic patients based on basic, clinical, observational studies and case reports. The significance of omalizumab therapy in asthma control and mechanisms that regulate the effects of omalizumab on eosinophils are evaluated.

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Section: Mechanisms Of Omalizumab Effect On Eosinophilsmentioning

confidence: 99%

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

Kupryś‐Lipińska¹,

Molińska²,

Kuna³

2016

Advances in Respiratory Medicine

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“…It, therefore, could play a role in the selection of Th2 or Th1 phenotypes of CD4 + T‐lymphocytes observed in Brazilian subjects. Eosinophils are also central in protection against helminths; IL‐13 increases vascular cellular adhesion molecule (VCAM)‐1 on endothelial cells (59), thus increasing the recruitment of eosinophils through VCAM‐1‐α4β1 interaction (60). Furthermore, IL‐13 increases CD69 expression on eosinophils (61) and GM‐CSF production by several cell types including epithelial cells (62).…”

Section: Il‐13 Alleles Determine Susceptibility To Infectionmentioning

confidence: 99%

Interleukin‐13 in the skin and interferon‐γ in the liver are key players in immune protection in human schistosomiasis

Dessein

Kouriba

Eboumbou

et al. 2004

Immunological Reviews

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“…5 a 4 b 1 Integrin mediates blood eosinophil adhesion to vascular cell adhesion molecule 1, preferentially induced on endothelium in response to T H 2 immunity mediators. 5 Integrin-mediated adhesion is a function of cell-surface integrin density, activation state, and ligand density. Although a 4 b 1 on purified blood eosinophils binds vascular cell adhesion molecule 1 constitutively, 5 the possibility exists that a 4 b 1 is activated in vivo on circulating eosinophils and the activation state is a determinant of eosinophil adhesion to activated endothelium and movement to the airway.…”

mentioning

confidence: 99%

“…5 Integrin-mediated adhesion is a function of cell-surface integrin density, activation state, and ligand density. Although a 4 b 1 on purified blood eosinophils binds vascular cell adhesion molecule 1 constitutively, 5 the possibility exists that a 4 b 1 is activated in vivo on circulating eosinophils and the activation state is a determinant of eosinophil adhesion to activated endothelium and movement to the airway. If so, blood eosinophil b 1 activation state may be a biomarker for the level of asthma activity or control.…”

mentioning

confidence: 99%

Eosinophil β1 integrin activation state correlates with asthma activity in a blind study of inhaled corticosteroid withdrawal

Johansson¹,

Barthel²,

Swenson³

et al. 2006

Journal of Allergy and Clinical Immunology

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Expression and function of beta1 integrins on human eosinophils

Cited by 22 publications

References 69 publications

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

The Effect of Omalizumab on Eosinophilic Inflammation of the Respiratory Tract in Patients with Allergic Asthma

Interleukin‐13 in the skin and interferon‐γ in the liver are key players in immune protection in human schistosomiasis

Eosinophil β1 integrin activation state correlates with asthma activity in a blind study of inhaled corticosteroid withdrawal

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