Expression and estrogen regulation of G protein‑coupled estrogen receptor in human glioblastoma cells

Peña‐Gutiérrez, Karla Mariana; Hernández‐Ortega, Karina; Bello-Álvarez, Claudia

doi:10.3892/ol.2022.13517

Cited by 7 publications

(6 citation statements)

References 65 publications

(83 reference statements)

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“…This may be an important reason why menopause leads to the development of cancer. Previous studies have implicated estrogen in the development and progression of various cancers, including ovarian and endometrial cancers ( 33 – 35 ). In our study, we looked at whether age at menopause was associated with the incidence of gynaecological cancers, using age of menopause as a variable.…”

Section: Discussionmentioning

confidence: 99%

Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES

Cheng,

Wang,

Sun

et al. 2023

Front. Endocrinol.

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BackgroundThe fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer.AimTo investigate whether the age at menopause is independently associated with the incidence of gynecological cancers and to analyze the possible influencing factors.MethodsWe selected the NHANES public database to conduct the study, and by excluding relevant influencing factors, we finally included 5706 NHANES participants who had full data on age at menopause and the occurrence of gynecologic cancers to analyze the relationship between the amount of age at menopause and gynecologic cancers based on univariate or multifactorial logistic regression analysis. Further, the relationship between age at menopause and the prevalence of different gynecologic cancers was investigated, and changes in the prevalence of different gynecologic cancers by age at menopause subgroups were observed. Finally, other relevant factors affecting the prevalence of gynecologic cancers were further investigated by subgroup analysis as well as subcluster analysis.ResultsUnivariate logistic regression analysis between age at menopause and gynecologic tumor prevalence revealed a negative association between age at menopause and the prevalence of common gynecologic cancers ovarian and cervical cancer, and after adjusting for the effects of covariates, a higher risk of gynecologic tumors was found with statistically significant differences at earlier age at menopause. The regression results showed a negative association between age at menopause and gynecologic cancer prevalence in cervical and ovarian cancer patients (P<0.01,P<0.01). Cervical cancer (OR: 0.91, 95% CI: 0.87,0.94) and ovarian cancer (OR: 0.90, 95% CI: 0.86, 0.95) were more prevalent among those with younger age at menopause.ConclusionAge at menopause is negatively associated with the prevalence of cervical and ovarian cancers, and the earlier the age at menopause, the greater the risk of developing gynecological cancers.

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Section: Discussionmentioning

confidence: 99%

Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES

Cheng,

Wang,

Sun

et al. 2023

Front. Endocrinol.

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“…In glioma, GPER was expressed in U87, LN229, T98, and U251 cell lines. In U87, LN229, and U251 cell lines, GPER was found in the cytoplasm and plasmatic membrane [29,123]. Additionally, GPER mRNA expression was lower in glioma cell lines than in human astrocytes [123], without differences in protein expression comparing glioma cells with human astrocytes or glial cells [123,124].…”

Section: Other Cancersmentioning

confidence: 94%

The G Protein-Coupled Estrogen Receptor GPER in the Development and Progression of Cancer

Torres-López,

Olivas-Aguirre,

Dobrovinskaya

2024

Receptors

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The high incidence of cancer and the prevalence of chemoresistance are serious problems worldwide, underscoring the urgency of novel research focused on understanding the underlying mechanisms and finding new therapeutic targets. Recently, the G protein-coupled estrogen receptor (GPER) has received increasing attention, and it has been studied in various models, including physiological and pathological conditions, using appropriate pharmacological and molecular biological strategies. Numerous studies indicate that GPER plays an important role in cancer progression and resistance. This review focuses on the structure of GPER, the diversity of its ligands and GPER-activated signaling pathways, the role of GPER in cancer progression, and mechanisms of chemoresistance, with special emphasis on different cancer types and the tumor microenvironment. GPER was evidenced to exhibit conformational plasticity and different ligand binding modes. Therefore, GPER-mediated effects can be triggered by estrogens or various estrogen mimetics, including synthesized compounds, licensed drugs, or exogenous environmental compounds. We found multiple reports evidencing that GPER is differentially expressed in healthy tissues and tumors and plays a protumor role in breast, ovarian, lung, thyroid, and endometrial cancers. Additionally, there are several studies that indicate that GPER expression in cells of the tumor microenvironment may also contribute to cancer progression. Among the major mechanisms of GPER-mediated chemoresistance are the epithelial-mesenchymal transition, the overexpression of multidrug resistance pumps, and autophagy regulation.

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“…Lately, estrogens have garnered a lot of attention due to the possibility of contributing to the development of GBM. Estrogens support cell proliferation and tumor growth through the presence of G protein-coupled estrogen receptor (GPER), which has been identified in C6 GBM cells [ 145 ], as well as in AS cell lines U251 [ 146 ]. Moreover, estrogen has been identified in the TME [ 147 ].…”

Section: The Importance Of Cell Crosstalk In Gliomasmentioning

confidence: 99%

Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas

Onciul,

Brehar,

Toader

et al. 2024

CIMB

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Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responses and the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinct and shared characteristics with other types of tumors.

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Expression and estrogen regulation of G protein‑coupled estrogen receptor in human glioblastoma cells

Cited by 7 publications

References 65 publications

Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES

Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES

The G Protein-Coupled Estrogen Receptor GPER in the Development and Progression of Cancer

Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas

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