Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma

Wang, Zhifeng; Liu, Qin-Jiang; Liao, Shiqi; Yang, Rong; Ge, Ting; He, Xin; Tian, Caiping; Liu, Wei

doi:10.1177/030089161109700420

Cited by 21 publications

(19 citation statements)

References 22 publications

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“…Na + /K -ATPase pump provides energy for this transport system [21] . Interestingly, NIS was demonstrated to be expressed in various normal non-thyroid tissues including salivary glands, lacrimal glands, breasts, stomach, intestine, lungs, and kidneys [22,23] . This finding may be associated with both the early/short-term and late/long-term side effects of RIT, including sialadenitis, xerostomia, gastritis, nausea/vomiting, dental caries, taste dysfunction, dry eye, and pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Short-term Effects of Radioiodine Therapy on Auditory Function

Edızer¹,

Bilici²,

Yıldız³

et al. 2017

Int Adv Otol

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OBJECTIVE:Radioiodine therapy (RIT) is frequently utilized as an adjunctive treatment option for differentiated thyroid carcinoma following surgical intervention. The side effects of RIT are considered to emerge as a result of radioiodine accumulation in non-thyroidal tissues capable of iodine uptake. We aimed to evaluate the effects of RIT on auditory function. MATERIALS and METHODS:Patients who had undergone total thyroidectomy and diagnosed to have differentiated thyroid carcinoma were analyzed. Those who were given RIT were included. Pure-tone audiometry and distortion product otoacoustic emission (DP-OAE) results were recorded along with patient demographics, RIT dose, and thyroid hormone profiles, both before and 3 months after RIT. RESULTS:Here, 63 patients were enrolled. Following RIT, audiometric thresholds at 0.25, 0.5, 4, and 8 kHz in addition to pure-tone average increased significantly; however, the change in DP-OAE results was not statistically significant at any frequency. The RIT dose had no effect on auditory function. CONCLUSION:In this study, we found some deleterious effects of RIT on audiometric thresholds, with no significant effect on DP-OAE results.

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Section: Discussionmentioning

confidence: 99%

Short-term Effects of Radioiodine Therapy on Auditory Function

Edızer¹,

Bilici²,

Yıldız³

et al. 2017

Int Adv Otol

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“…The majority of the studies have, however, been directed at deciphering the interactions of the proto-oncogene B-raf (BRAF V600E ) with the NIS gene in cancer. In general, the studies have led to the notion that, in resistant thyroid tumors, the BRAF V600E mutation was related to the downregulation of the NIS and thyroid stimulating hormone expression (Wang et al, 2011;Sodre et al, 2008), despite high cytosolic NIS protein expression (Wang et al, 2011). This has been linked to the inability of the NIS to migrate to the cellular basolateral membrane (Sodre et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The potential role of the sodium iodide symporter gene polymorphism in the development of differentiated thyroid cancer

Al‐Rasheed

Alzahrani

Macadam

et al. 2015

Gene

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“…The main regulator of NIS expression in the thyroid is the thyroid stimulating hormone (TSH) [27, 28]. TSH stimulation of the TSH receptor initiates a G-protein-mediated signaling cascade that ultimately results in an increase in NIS mRNA and protein in thyroid follicular cells, and regulates the post-transcriptional phosphorylation and plasma membrane targeting of NIS [29-33]. …”

Section: Structure Function and Regulation Of Nis In The Thyroidmentioning

confidence: 99%

The Sodium Iodide Symporter (NIS) as an Imaging Reporter for Gene, Viral, and Cell-based Therapies

Penheiter

Russell²,

Carlson³

2012

CGT

111

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Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-invasive imaging of reporter gene products to reveal the distribution of molecular therapeutics within living subjects. Reporter gene and probe combinations can be employed to monitor vectors for gene, viral, and cell-based therapies. There are several reporter systems available; however, those employing radionuclides for positron emission tomography (PET) or singlephoton emission computed tomography (SPECT) offer the highest sensitivity and the greatest promise for deep tissue imaging in humans. Within the category of radionuclide reporters, the thyroidal sodium iodide symporter (NIS) has emerged as one of the most promising for preclinical and translational research. NIS has been incorporated into a remarkable variety of viral and non-viral vectors in which its functionality is conveniently determined by in vitro iodide uptake assays prior to live animal imaging. This review on the NIS reporter will focus on 1) differences between endogenous NIS and heterologously-expressed NIS, 2) qualitative or comparative use of NIS as an imaging reporter in preclinical and translational gene therapy, oncolytic viral therapy, and cell trafficking research, and 3) use of NIS as an absolute quantitative reporter.

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Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma

Cited by 21 publications

References 22 publications

Short-term Effects of Radioiodine Therapy on Auditory Function

Short-term Effects of Radioiodine Therapy on Auditory Function

The potential role of the sodium iodide symporter gene polymorphism in the development of differentiated thyroid cancer

The Sodium Iodide Symporter (NIS) as an Imaging Reporter for Gene, Viral, and Cell-based Therapies

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