Expression and clinicopathological significance of the lncRNA HOXA11-AS in colorectal cancer

Li, Tong; Xu, Chengfei; Cai, Bin; Zhang, Meng; Gao, Feng; Gan, Jialiang

doi:10.3892/ol.2016.5129

Cited by 44 publications

(36 citation statements)

References 32 publications

(27 reference statements)

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“…LncRNAs are classified according to the correlation between their location and the location of the corresponding protein-coding gene, such as sense, antisense, intergenic, intronic and bidirectional lncRNAs (18,19). Aberrant expression of lncRNAs may contribute to the development and progression of various cancers (20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

et al. 2017

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Abstract. The aim of the present study was to determine whether there is an association between the long non-coding RNA (lncRNA) prostate cancer-associated non-coding RNA 1 (PRNCR1) polymorphisms and prostate cancer (PCa) risk in a sample of the Iranian population. This case-control study was performed on 178 patients with PCa and 180 subjects with benign prostatic hyperplasia (BPH). Genotyping assay was performed by polymerase chain reaction-restriction fragment length polymorphism. The findings indicated that the GG genotype of the rs13252298 A>G variant significantly increased the risk of PCa (odds ratio=3.49, 95% confidence interval: 1.79-6.81, P=0.0001) compared with AA+AG. As regards the rs1456315 G>A polymorphism, the AG genotype and G allele significantly increased the risk of PCa. As regards the rs7841060 T>G variant, the findings demonstrated that this TG genotype and the G allele significantly increased the risk of PCa. The rs7007694 T>C variant was not found to be associated with the risk of PCa. Haplotype analysis indicated that GTGA and GTGG significantly increased the risk of PCa compared with rs1456315A/rs7007694T/rs7841060T/rs13252298G (ATTG). The PRNCR1 variants were not found to be significantly associated with the clinicopathological characteristics of PCa patients. In conclusion, our findings support an association between PRNCR1 variants and the risk of PCa in a sample of the Iranian population.

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Section: Introductionmentioning

confidence: 99%

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

et al. 2017

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“…In short, HOXA11‐AS/miR‐125a‐5p/PADI2 regulatory network can regulate the metastasis and invasion of CRC, which has found a new therapeutic target for the treatment and prevention of CRC metastasis. In addition, HOXA11‐AS was also significantly associated with lymph node metastasis, TNM staging, tumor size, and CEA levels in patients with CRC (Li et al, ). However, the specific regulatory mechanism is not yet clear and needs further study.…”

Section: Hoxa11‐as In Malignant Tumorsmentioning

confidence: 99%

The role of the long non‐coding RNA HOXA11‐AS in promoting proliferation and metastasis of malignant tumors

Jiang

et al. 2018

Cell Biology International

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Long non-coding RNA (lncRNA) is one of the focuses and hotspots of biological research in recent years. At the same time, tumors have become the main disease that endangers human health. In recent years, a large number of researchers have explored the relationship between lncRNA and tumors. HOXA11-AS is one of these lncRNAs. The long non-coding RNA HOXA11 antisense RNA (HOXA11-AS) is a novel lncRNA recently discovered. It is found in a variety of tumors such as ovarian cancer, glioma, and gastric cancer (GC) and so on, and is defined as an oncogene. It promotes tumor proliferation and metastasis by interacting with proteins such as miRNA and EZH2. In this paper, we review the mechanism of interaction between HOXA11-AS and various tumors in recent years, and believe that it can be a potential tumor marker and therapeutic target in the future prevention and treatment of tumors.

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“…Устойчивое повышение уровня 2',5'-олигоаденилата в клетке переводит её в состояние покоя [71,72]. Следует отметить, что Gly-рецепторы не только передают сигнал от сенсорных нейронов к моторным, но и участвуют в восприятии боли, передаче фотосигналов и развитии нервной системы [80][81][82][83]. Gly-синапсы играют важную роль в восприятии света сетчаткой.…”

Section: значение глициновых рецепторов для функциональной активностиunclassified

“…Gly-синапсы играют важную роль в восприятии света сетчаткой. В различных клетках сетчатки присутствуют Gly-R s из различных субъединиц [82], и хотя они могут встречаться в одном слое, доказано, что вероятность их нахождения в одном и том же синапсе менее 10% [82]. Таким образом, в одном синапсе присутствует один тип Gly-R s , и, видимо, разные типы таких рецепторов выполняют различные функции в сетчатке.…”

Section: значение глициновых рецепторов для функциональной активностиunclassified

Glycine receptors in nervous tissue and their functional role

Nikandrov

Балашевич

2014

BIOMED KHIM

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The literature data on glycine metabolism in neural tissue, mitochondrial Gly-cleaving system, Gly-catching system in neural and glial cells are summarized. The peculiarities of localization and distribution of specific glycine receptors and binding-sites in nervous tissue of mammals are described. Four types of glycine-binding receptors are described: own specific glycine receptor (Gly-R), ionotropic receptor, which binds N-methyl-D-aspartate selectively (NMDA-R), and ionotropic receptors of g-aminobutyrate (GABA A -R, GABA С -R). The feutures of glycine effects in neuroglial cultures are discussed

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Expression and clinicopathological significance of the lncRNA HOXA11-AS in colorectal cancer

Cited by 44 publications

References 32 publications

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

Association between genetic polymorphisms of long non‑coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population

The role of the long non‐coding RNA HOXA11‐AS in promoting proliferation and metastasis of malignant tumors

Glycine receptors in nervous tissue and their functional role

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