2012
DOI: 10.1007/s12022-012-9197-8
|View full text |Cite
|
Sign up to set email alerts
|

Expression and Clinical Significance of Wnt Players and Survivin in Pituitary Tumours

Abstract: Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACTH-secreting tumour) and six normal controls was undertaken in this study and correlation of protein expression to patient and tumour characteristics analysed. β-catenin was strictly membrane-bound… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
22
0

Year Published

2013
2013
2022
2022

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 25 publications
(22 citation statements)
references
References 44 publications
0
22
0
Order By: Relevance
“…In contrary to these results, Jankowska et al reported that survivin mRNA expression was 6 fold higher in patients with pituitary adenomas than in controls in one of their study. Moreover, there was not any statistically significance in survivin expression between invasive and non-invasive pituitary adenomas (16). In recent years, various studies have investigated serum survivin levels in many cancer types and revealed conflicting data.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…In contrary to these results, Jankowska et al reported that survivin mRNA expression was 6 fold higher in patients with pituitary adenomas than in controls in one of their study. Moreover, there was not any statistically significance in survivin expression between invasive and non-invasive pituitary adenomas (16). In recent years, various studies have investigated serum survivin levels in many cancer types and revealed conflicting data.…”
Section: Discussionmentioning
confidence: 93%
“…In addition to studies investiga-ting expression of survivin in various human tumors, there are also some researches investiga-ting survivin expression in somatotroph adenomas to demonstrate its involvement in pituitary tumorigenesis (1,(15)(16)(17)(18). Hovewer, no data are available concerning circulating levels of the survivin in patients with pituitary adenomas.…”
Section: Introductionmentioning
confidence: 99%
“…As an antineoplastic factor, miRNA-27a inhibited the Wnt/β-catenin signaling pathway to influence proliferation, migration and invasion ability of glioma cells [21]. The β-catenin signaling pathway was an important part of the Wnt signaling pathway, which influenced the expression of the downstream gene [23]. This proved that Wnt signaling played a fundamental role in the development and maintenance of many organs [24].…”
Section: Discussionmentioning
confidence: 99%
“…They suggested that WIF1 may be a tumor suppressor, specifically in NFPAs, and the Wnt pathway is important in pituitary tumorigenesis [29]. However, this finding was not validated by other reports showing no activation of canonical and noncanonical Wnt pathway activation in pituitary adenoma [30,31]. Based on these discrepant results further studies are warranted for clarification of the role of miRNAs targeting molecules involved in Wnt signaling in pituitary adenomagenesis.…”
Section: Discussionmentioning
confidence: 91%