Expression and Clinical Significance of Antinuclear Antibody in Hepatitis C Virus Infection

Peng, Yen‐Chun; Hsieh, Song-Chou; Yang, Dar-Yu; Tung, C. J.; Hu, Wei-Hsiung; Huang, Wen‐Nan; Chen, Gran‐Hum

doi:10.1097/00004836-200111000-00012

Cited by 33 publications

(23 citation statements)

References 35 publications

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“…The results of logistic regression analysis performed on biomarkers and viral load revealed that elevation of alkaline phosphates enzyme levels is a biomarker for detecting HCV infection. This finding correlated with the reports published by the other research groups [32][33][34][35][36][37]. The degree of HCV infection has been associated with increased viral load [38].…”

Section: Discussionsupporting

confidence: 90%

A Correlative Study on Hepatitis C Virus Load Determined by Real Time Polymerase Chain Reaction with Serum Biomarkers in Patients with Renal Disease

Bagyalakshmi¹,

Malathi²,

Prathiba³

2012

J Mol Biomark Diagn

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Purpose: To determine the Hepatitis C virus (HCV) load in peripheral blood specimens of patients with renal abnormality reporting to the nephrology unit and to correlate the viral load with different biomarkers in serum. Materials and Methods:Fifty peripheral blood specimens were obtained from patients reporting to the nephrology unit and these patients were categorized into three groups as Group I: Renal Transplant patients, Group II: Dialysis patients, Group III: Other patients. with elevated liver enzymes and renal pathology. Peripheral blood specimens collected from kidney transplant recipients (n = 11), dialysis (n=17) and others (n =22) were subjected to detection of antibodies to HCV, determination of viral load by Real Time PCR and biochemical profiling consisting of estimation of bilirubin, total protein, alanine aminotransferase, and alkaline phosphatase. Antibodies to HCV were detected by ELISCAN™ HCV and the viral load by using HCV RG RTPCR kit (QIAGEN, Hilden). Statistical analysis -T test and the logistic regression analysis assessing the correlation between viral load and serum bilirubin, Serum glutamate pyruvate transaminase (SGPT), Alkaline phosphatase, total protein were performed using SPSS software version 14.0Results: Antibodies to HCV were detected by ELISA in 39 (78%) peripheral blood samples and genomic HCV was detected in 31 (62%) by RTPCR. In 8 (16%) patients, HCV antibodies only were detected and RTPCR did not reveal the presence of HCV in these specimens. Logistic regression analysis performed on biochemical parameters and viral load revealed correlation between alkaline phosphatase enzyme levels and viral load (Hosmer and Lemehow test P value< 0.05 statistically significant).

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Section: Discussionsupporting

confidence: 90%

A Correlative Study on Hepatitis C Virus Load Determined by Real Time Polymerase Chain Reaction with Serum Biomarkers in Patients with Renal Disease

Bagyalakshmi¹,

Malathi²,

Prathiba³

2012

J Mol Biomark Diagn

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“…This results was agreed with Khairy et al (Khairy et al, 2013b), Peng et al (Peng et al, 2001) and Yehia et al (Rania I.Mabrouk Yehia s.Younes 2015)results.…”

Section: P=0009supporting

confidence: 92%

Circulating IL17a and IFN-Gamma Serum Levels in Cirrhotic Hepatitis C Virus Infected Patients with Autoimmune Thyroiditis

Elkady¹,

Mohamed²,

Tohamy³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…A standard ANA is not defined in relation to liver diseases, although there is greater association of homogeneous and speckled patterns with autoimmune hepatitis 50 . In patients with HCV, the speckled pattern is described most frequently and was shown to be present in 68 to 91% of patients with positive ANA 12,47 .…”

Section: Discussionmentioning

confidence: 99%

“…The presence of ANAs may be a sign of autoimmune hepatitis and other inflammatory conditions such as systemic lupus erythematosus 45,46 . Although ANAs can be present in these diseases, in the cases of individuals with HCV, these typically signify only an epiphenomenon 11,47 . The incidence of ANA among individuals infected with HCV is higher than that of the general population, ranging from 4.4 to 23% 12,35,36,41,47,48 , a rate similar to the 7.6% prevalence evidenced in this study.…”

Section: Discussionmentioning

confidence: 99%

Autoantibody profile in individuals with chronic hepatitis C

Marconcini

Fayad

Shiozawa

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Autoantibodies are often produced during infection with chronic hepatitis C virus (HCV), but it remains controversial whether they influence the biochemical profile and histological features of this disease. Therefore, this current study sought to describe these autoantibodies and evaluate their impact on the clinical and histological presentation of hepatitis C. Methods: This cross-sectional analytical study assessed patients with HCV (RNA+) from October 2011 to July 2012. Results: This study included 66 patients, with a mean age of 53.2±10.5 years. Of these patients, 60.6% were male, and 54.3% presented with genotype 1. Non-organ-specific autoantibodies (NOSA) were detected in 24% of the patients; of these, 7.6% were anti-mitochondrial antibodies (AMA+), 26.7% were anti-smooth muscle antibodies (SMA+) and 6.8% were liver kidney microsomal type 1 antibodies (LKM1+). With respect to the thyroid autoantibodies, 7.4% were anti-peroxidase (ATPO+) antibodies, and none were anti-thyroglobulin (ATG+) antibodies. Regarding celiac disease autoantibodies, 5.8% were endomysial antibodies (EMA+), and no transglutaminase (TTG+) antibodies were detected. Cryoglobulins were found in 2.1% of patients. When NOSA+ individuals were compared to patients without the presence of NOSAs, they exhibited higher median alkaline phosphatase (0.7 vs. 0.6 xULN; p=0.041), lower median platelet counts (141,500.0 vs. 180,500.0/mm 3 ; p=0.036), lower mean prothrombin activity (72.6±11.5% vs. 82.2±16.0%; p=0.012) and an increased prevalence of significant fibrosis (E≥2) (45.5% vs. 18.2%; p=0.012). There was also a tendency for a greater proportion of NOSA+ cases to have marked periportal activity (APP≥3) (44.5% vs. 15.6%; p=0.087). Conclusions: In addition to the high prevalence of autoantibodies associated with HCV infection, it was observed that NOSA positivity was associated with a more severe histological and biochemical profile of hepatitis C infection.

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Expression and Clinical Significance of Antinuclear Antibody in Hepatitis C Virus Infection

Cited by 33 publications

References 35 publications

A Correlative Study on Hepatitis C Virus Load Determined by Real Time Polymerase Chain Reaction with Serum Biomarkers in Patients with Renal Disease

A Correlative Study on Hepatitis C Virus Load Determined by Real Time Polymerase Chain Reaction with Serum Biomarkers in Patients with Renal Disease

Circulating IL17a and IFN-Gamma Serum Levels in Cirrhotic Hepatitis C Virus Infected Patients with Autoimmune Thyroiditis

Autoantibody profile in individuals with chronic hepatitis C

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