Expression and clinical significance of CRABP1 and CRABP2 in non-small cell lung cancer

Favorskaya, I. A.; Kainov, Yaroslav A.; Chemeris, Galina; Komelkov, A. V.; Zborovskaya, I. B.; Tchevkina, Elena M.

doi:10.1007/s13277-014-2348-4

Cited by 37 publications

(34 citation statements)

References 26 publications

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“…Genes CRABP1, AGPHD1 (also called HYKK), and CHRNA3 are nearby the highly significant locus on chromosome 15, and have been identified in previous literature as potentially associated with lung cancer. AGPHD1 and CHRNA3 have been associated with lung cancer via GWAS‐type analyses (Wang et al, ), while CRABP1 has been associated with lung cancer via an analysis of messenger RNA (Favorskaya et al, ), providing further evidence that the dysregulation of CRABP1 affects lung cancer risk.…”

Section: Resultsmentioning

confidence: 99%

Integrating germline and somatic genetics to identify genes associated with lung cancer

Pattee

Zhan

Xiao

et al. 2019

Genetic Epidemiology

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Genome‐wide association studies (GWAS) have successfully identified many genetic variants associated with complex traits. However, GWAS experience power issues, resulting in the failure to detect certain associated variants. Additionally, GWAS are often unable to parse the biological mechanisms of driving associations. An existing gene‐based association test framework, Transcriptome‐Wide Association Studies (TWAS), leverages expression quantitative trait loci data to increase the power of association tests and illuminate the biological mechanisms by which genetic variants modulate complex traits. We extend the TWAS methodology to incorporate somatic information from tumors. By integrating germline and somatic data we are able to leverage information from the nuanced somatic landscape of tumors. Thus we can augment the power of TWAS‐type tests to detect germline genetic variants associated with cancer phenotypes. We use somatic and germline data on lung adenocarcinomas from The Cancer Genome Atlas in conjunction with a meta‐analyzed lung cancer GWAS to identify novel genes associated with lung cancer.

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Section: Resultsmentioning

confidence: 99%

Integrating germline and somatic genetics to identify genes associated with lung cancer

Pattee

Zhan

Xiao

et al. 2019

Genetic Epidemiology

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“…Increasing study report that dysregulated CRABP2 is associated with the progression of tumors [30]. CRABP2 is highly expressed in pancreatic ductal adenocarcinoma [30], breast cancer [31], and non-small cell lung cancer (NSCLC) [32], its high expression is associated with poor prognosis of patients with NSCLC or ER-negative breast cancer [32,33]. Yu S et al report that CRABP2 promotes the invasion of pancreatic cancer cells through stabilizing the interleukin 8 expression [34].…”

Section: Discussionmentioning

confidence: 99%

Dezocine inhibits cell proliferation, migration and invasion by targeting CRABP2 in ovarian cancer

Zhang¹,

R²,

Ma³

et al. 2020

Preprint

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Background: Previous studies have shown that some anesthesia drugs can inhibit tumor growth and metastasis. As a clinical anesthetic drug, dezocine has been reported to play an important role in immune function. However, the effects of dezocine on ovarian cancer cell growth and metastasis are not fully understood. Results: In this study, we found that dezocine dose-dependently inhibited the viability of ovarian cancer ES-2 and SKOV3 cells. Dezocine suppressed the migration and invasion abilities of ovarian cancer cells and promoted apoptosis. Moreover, the Akt/mTOR signaling pathway was also inhibited by dezocine. Furthermore, the mechanism study showed that dezocine could significantly inhibit the expression of CRABP2, and CRABP2 overexpression reversed the inhibitory effects of dezocine on ovarian cancer cell proliferation and migration. Conclusions: In conclusion, dezocine has significant anti-tumor effects on the growth and metastatic potential of ovarian cancer cells, and CRABP2 functions as a downstream effector of dezocine.

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“…It has been established that CRABP2 transports ATRA into the nucleus and enhances the biological activity of ATRA via regulating target gene transcription (Weston et al., ; Favorskaya et al., ). The present research revealed that CRABP2 could mediate the effect of ATRA on the expression of COL9A1 in antler chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

ATRA Signaling Regulates the Expression of COL9A1 through BMP2‐WNT4‐RUNX1 Pathway in Antler Chondrocytes

et al. 2017

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Although all-trans retinoic acid (ATRA) is involved in the regulation of cartilage growth and development, its regulatory mechanisms remain unknown. Here, we showed that ATRA could induce the expression of COL9A1 in antler chondrocytes. Silencing of cellular retinoic acid binding protein 2 (CRABP2) could impede the ATRA-induced upregulation of COL9A1, whereas overexpression of CRABP2 presented the opposite effect. RARα agonist Am80 induced the expression of COL9A1, whereas treatment with RARα antagonist Ro 41-5253 or RXRα small-interfering RNA (siRNA) caused an obvious blockage of ATRA on COL9A1. In antler chondrocytes, CYP26A1 and CYP26B1 weakened the sensitivity of ATRA to COL9A1. Simultaneously, Bone morphogenetic protein 2 (BMP2) and WNT4 mediated the regulation of ATRA on COL9A1 expression. Knockdown of WNT4 could abrogate the inhibitory effect of BMP2 overexpression on COL9A1. Conversely, constitutive expression of WNT4 reversed the upregulation of COL9A1 elicited by BMP2 siRNA. Together these data indicated that WNT4 might act downstream of BMP2 to mediate the effect of ATRA on COL9A1 expression. Further analysis evidenced that attenuation of runt-related transcription factor 1 (RUNX1) could prevent the stimulation of ATRA on COL9A1 expression, while exogenous rRUNX1 further enhanced this effectiveness. Moreover, RUNX1 might serve as an intermediate to mediate the regulation of BMP2 and WNT4 on COL9A1 expression. Collectively, ATRA signaling might regulate the expression of COL9A1 through BMP2-WNT4-RUNX1 pathway.

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Expression and clinical significance of CRABP1 and CRABP2 in non-small cell lung cancer

Cited by 37 publications

References 26 publications

Integrating germline and somatic genetics to identify genes associated with lung cancer

Integrating germline and somatic genetics to identify genes associated with lung cancer

Dezocine inhibits cell proliferation, migration and invasion by targeting CRABP2 in ovarian cancer

ATRA Signaling Regulates the Expression of COL9A1 through BMP2‐WNT4‐RUNX1 Pathway in Antler Chondrocytes

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