Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma

Deng, Lu; Gao, Yiping; Li, Xiao; Cai, Mingbo; Wang, Huimin; Zhuang, Huiyu; Tan, Mingzi; Liu, Shuice; Hao, Yingying; Lin, Bei

doi:10.1186/s13046-015-0208-8

Cited by 48 publications

(63 citation statements)

References 36 publications

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“…These results indicate that Annexin 2 may be an independent prognostic factor for hepatocellular carcinoma (20). Previous studies have demonstrated that the expression of Annexin A2 is significantly associated with metastasis and poor survival in nasopharyngeal and endometrial carcinoma, bladder cancer and serous ovarian cancer (21)(22)(23)(24). Using a proteomic assay, the present study identified that Annexin A2 was highly expressed in laryngeal carcinoma tissues, consistent with the results of the aforementioned studies.…”

Section: Discussionsupporting

confidence: 80%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

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Abstract. Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

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Section: Discussionsupporting

confidence: 80%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

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“…Because CA 125 is often elevated in benign conditions or as a result of physiologic changes in premenopausal women, it has not any confirmed role in the early detection of gynecologic cancers. Since abnormal levels of HE4 have been less frequently encountered in benign gynecological conditions HE4 may have increased specificity in differentiating between benign and malignant conditions [2][3][4][5][6][7]. In the present study, we have found that HE4 tissue expression increased in carcinomas, but decreased in intraepithelial neoplasia.…”

Section: Discussionsupporting

confidence: 64%

“…Conversely, HE4 overexpression has not been detected in ovarian mucinous tumors [4][5][6], non-epithelial ovarian cancers, sex cord stromal tumors and germ cell tumors. However overexpression of HE4 has been detected in primary tuba uterina carcinomas and endometrial malignancies [2][3][4][5][6][7]. Among non-gynecological cancers, HE4 expression has been also demonstrated in various subtypes of lung cancer [12].…”

Section: Discussionmentioning

confidence: 99%

“…Majority of secretory cells such as glandular epithelium of the breast and female genital tract, epididymis, vas deferens, distal renal tubules, respiratory epithelium and salivary glands show strong HE4 positivity [6]. Physiopathologically, HE4 probably involves in cancer progression and metastases [7]. In intact tissues of trachea and salivary gland highest levels of HE4 expression, while in lung, prostate, pituitary gland, thyroid and kidney lower HE4 positivity have been detected.…”

Section: Introductionmentioning

confidence: 98%

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Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors

Dınız

Karadeniz²,

Sayhan³

et al. 2017

Ginekol Pol

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Objectives: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors. Material and methods:This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases.Results: Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors. Conclusions:This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas.

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“…Similar results were found in the study of Deng et al In their study, HE4 expression in endometrial tissues was significantly higher in EC tissues as compared to the normal endometrium. HE4 was also significantly correlated with the degree of cancer differentiation [24].…”

Section: Discussionmentioning

confidence: 87%

The role of HE4 and CA125 in differentiation between malignant and non-malignant endometrial pathologies

et al. 2016

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Objectives: The aim of the study was to assess the role of HE4 and CA125 in differentiation between malignant and non-malignant endometrial pathologies. Material and methods:A retrospective study of 87 patients with endometrial pathologies was conducted. Tumor markers were assessed two weeks before surgical intervention in each subject. The final diagnosis was established on the basis of the histopathological examination of the endometrium.Results: Serum HE4 levels were significantly higher in patients with endometrial cancer (EC) as compared to non-malignant endometrial pathologies (p < 0.001), patients with stage I EC as compared to non-malignant endometrial pathologies (p < 0.001), and patients with stage Ia EC as compared to non-malignant endometrial pathologies (p = 0.003). Serum CA125 levels were not significantly different as far as these groups of patients were concerned. Both tumor markers were significantly higher in patients with stage II-III as compared to stage I EC and non-malignant endometrial pathologies (p < 0.001 for both markers). Sensitivity and specificity of HE4 at the cut-off level of 70 pmol/L for detecting endometrial malignancies were 73.08% and 85.71%, respectively. Sensitivity and specificity of CA125 at the cut-off level of 35 U/mL were 29.41% and 94.29%, respectively. The area under the curve (AUC) for HE4 was 0.875, suggesting that this marker reliably differentiates malignant from non-malignant endometrial pathologies (p < 0.001). AUC for CA125 was 0.552, suggesting that this marker does not reliably differentiate between malignant and non-malignant endometrial pathologies (p = 0.414).Conclusion: HE4, in contrast to CA125, might be a useful tool for detecting malignant endometrial pathologies.

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Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma

Cited by 48 publications

References 36 publications

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors

The role of HE4 and CA125 in differentiation between malignant and non-malignant endometrial pathologies

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