Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis

Wen, Jianting; Liu, Jian; Wang, Xin; Wang, Jie

doi:10.1016/j.intimp.2021.107366

Cited by 19 publications

(7 citation statements)

References 32 publications

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“…The circ_0003353 and circ_0091685 were up-regulated, whereas circ_0005732, circ_0072428 were downregulated. Then, the expression of circ_0003353 in fibroblast-like synoviocytes was further investigated for functional phenotype analysis; circ_0003353 was significantly highly expressed, it could promote of FLS inflammatory response and cell apoptosis, but inhibited cell proliferation (163). Although a series of dysregulation circRNAs were found in RA, their downstream pathways in regulating autoimmunity and inflammation are still poorly revealed.…”

Section: Circrnas and Ramentioning

confidence: 99%

Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis

2022

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Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that affect synovitis, bone, cartilage, and joint. RA leads to bone and cartilage damage and extra-articular disorders. However, the pathogenesis of RA is still unclear, and the lack of effective early diagnosis and treatment causes severe disability, and ultimately, early death. Accumulating evidence revealed that the regulatory network that includes long non-coding RNAs (lncRNAs)/circular RNAs (circRNAs), micro RNAs (miRNAs), and messenger RNAs (mRNA) plays important roles in regulating the pathological and physiological processes in RA. lncRNAs/circRNAs act as the miRNA sponge and competitively bind to miRNA to regulate the expression mRNA in synovial tissue, FLS, and PBMC, participate in the regulation of proliferation, apoptosis, invasion, and inflammatory response. Thereby providing new strategies for its diagnosis and treatment. In this review, we comprehensively summarized the regulatory mechanisms of lncRNA/circRNA-miRNA-mRNA network and the potential roles of non-coding RNAs as biomarkers and therapeutic targets for the diagnosis and treatment of RA.

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Section: Circrnas and Ramentioning

confidence: 99%

Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis

2022

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“…Also, it was confirmed that circRNAs could be involved in the inflammatory response of RA through acting on RA inflammatory cytokines. For example, hsa_circ_0003353 [ 23 ] was confirmed to have significantly higher expression in RA -FLS. Meanwhile, after the inhibition and over-expression of hsa_circ_0003353, the proliferation, migration, invasion, apoptosis of RA-FLS and the production of inflammatory cytokines showed significant changes, suggesting that hsa_circ_0003353 may play an important role in the promotion of immunity, inflammation, synovial infiltration and joint destruction.…”

Section: Discussionmentioning

confidence: 99%

Expression profile of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Yang

Kuang

et al. 2022

BMC Med Genomics

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Background Circular RNAs (circRNAs) is a newly discovered non-coding RNA that can be used as biomarkers in clinical blood samples. This study aims to screen differentially expressed circular RNAs in PBMCs of patients with rheumatoid arthritis (RA) to determine new biomarkers for the diagnosis of RA. Methods The differentially expressed circRNAs in peripheral blood mononuclear cells (PBMCs) of 4 RA patients and 4 healthy participants were screened and analyzed by gene microarray technology. We then validated some of the differentially expressed circRNAs in PBMCs of 20 RA patients, 10 systemic lupus erythematosus (SLE) patients and 20 healthy participants using reverse transcription-quantitative polymerase chain reaction amplification (RT-qPCR). Spearman correlation test was performed to analyze the correlation between differentially expressed circRNAs and clinical variables in RA patients. Receiver operating characteristic (ROC) curves were calculated to evaluate the diagnostic value of circRNAs. Results Differential analysis obtained 149 circRNAs with significant up-regulated expression and 250 circRNAs with significant down-regulated expression, which predicted the miRNA targets and binding sites. Compared with SLE and health control group, hsa_circ_101328 was found to be a common gene with differential expression of RA. Besides, correlation analysis revealed significant correlation between hsa_circ_101328 and positive CRP. ROC curve analysis showed that hsa_circ_101328 has the potential of RA diagnosis. Conclusion We identified some dysregulated circRNAs in PBMCs from RA patients, and hsa_circ_101328 may be a novel and effective biomarker for early diagnosis of RA.

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“…Clinical statistical analysis also indicated that CIRC_0003353 exhibited higher receiver operator characteristic relevance and was significantly correlated with erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor. 48 Similarly, through differential analysis, Lu et al found that hsa_circ_101328 is differentially expressed in RA and significantly correlated with Creactive protein positivity in patients with RA. 49 Peng et al reported that circNUP214 could act as a sponge for miR-125a-3p, regulating the transcript levels of IL-23 receptors in the PBMCs of patients with RA to promote the expression of the pro-inflammatory factor IL-17A.…”

Section: Circul Ar Rna S In Rheumatoid Arthritismentioning

confidence: 98%

“…46,47 In our previous study, we documented that inflammatory and immune-related circRNA expression profiles were significantly altered in the PBMCs of patients with RA, and hsa_circ_0003353 was highly expressed in RA-FLS. 48 In addition, inhibition or overexpression of CIRC_0003353 resulted in altered cell proliferation, apoptosis, migration, invasion, and inflammatory cytokine production in RA-FLS. Clinical statistical analysis also indicated that CIRC_0003353 exhibited higher receiver operator characteristic relevance and was significantly correlated with erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor.…”

Section: Circul Ar Rna S In Rheumatoid Arthritismentioning

confidence: 99%

Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action

Liu

Jiang

et al. 2023

Int J of Rheum Dis

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Previous studies have shown that autophagic pathogenesis of rheumatoid arthritis (RA) is regulated by circular RNAs (circRNAs), which accelerate bone damage by participating in the immune inflammatory response. Therefore, exploring the mechanisms underlying circRNA regulation of autophagy is essential for maintaining homeostasis of the skeletal microenvironment in RA and may improve our understanding of the specific pathways involved in the development of therapeutics. In this review, we discuss autophagic imbalance in RA and the regulatory mechanisms of circRNAs. We also explore possible targets for circRNA regulation of autophagy in RA, which may provide us with improved knowledge regarding the pathogenesis of RA.

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Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis

Cited by 19 publications

References 32 publications

Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis

Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis

Expression profile of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action

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