Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma

Zhang, Hui; Gao, Hong-Li; Liu, Chengli; Kong, Yalin; Wang, Cheng; Zhang, Hongyi

doi:10.1186/s13000-015-0253-9

Cited by 21 publications

(25 citation statements)

References 15 publications

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“…HSPA2 has been found to overexpress in many cancer types. Furthermore, patients with higher HSPA2 expression had shorter overall survival compared with lower HSPA2 patients [ 27 – 30 ]. These are consistent with our in vitro data that HSPA2 plays an oncogenic role in NSCLC cell lines.…”

Section: Discussionmentioning

confidence: 99%

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

Chang

Hsiao

et al. 2016

PLoS ONE

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JAG1 is a Notch ligand that plays a critical role in multiple signaling pathways. However, the functionality of JAG1 in non-small cell lung cancer (NSCLC) has not been investigated thoroughly. By comparison of gene transcripted RNA profiles in the cell line pair with differential invasion ability, we identified JAG1 as a potential metastasis enhancer in lung cancer. Ectopic expression of JAG1 on lung cancer cells enhanced cell migration and invasion as well as metastasis in vitro and in vivo. Conversely, knockdown of JAG1 with siRNA in highly invasive cancer cells led to the reduction of migration and invasion. In clinical analysis, JAG1 mRNA expression was higher in tumors than in adjacent normal tissues in 14 of 20 patients with squamous cell carcinoma (SCC). SCC patients with higher JAG1 transcription had poor overall survival than those with low-transcripted JAG1. Microarray analysis indicated that the enforced JAG1 transcription was associated with an elevated HSPA2 RNA transcription, which played a role in promoting cancer cell migration and invasion. In conclusion, this is the first study that demonstrated that JAG1 might act as a potential prognostic marker and JAG1/HSPA2 axis mediates lung cancer malignancy at least partly.

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Section: Discussionmentioning

confidence: 99%

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

Chang

Hsiao

et al. 2016

PLoS ONE

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“…During this process, HSPA2 was found with different characters in our breast cancer data compared with previous reported study in other cancer types. HSPA2 is a member of the HSP70 family of heat shock proteins and is important for cancer cell growth and metastasis [ 19 ]. HSPA2 has been highlighted as an important biomarker in many cancer types.…”

Section: Resultsmentioning

confidence: 99%

Identification of Gene Expression Pattern Related to Breast Cancer Survival Using Integrated TCGA Datasets and Genomic Tools

Huang

Duan

2015

BioMed Research International

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Several large-scale human cancer genomics projects such as TCGA offered huge genomic and clinical data for researchers to obtain meaningful genomics alterations which intervene in the development and metastasis of the tumor. A web-based TCGA data analysis platform called TCGA4U was developed in this study. TCGA4U provides a visualization solution for this study to illustrate the relationship of these genomics alternations with clinical data. A whole genome screening of the survival related gene expression patterns in breast cancer was studied. The gene list that impacts the breast cancer patient survival was divided into two patterns. Gene list of each of these patterns was separately analyzed on DAVID. The result showed that mitochondrial ribosomes play a more crucial role in the cancer development. We also reported that breast cancer patients with low HSPA2 expression level had shorter overall survival time. This is widely different to findings of HSPA2 expression pattern in other cancer types. TCGA4U provided a new perspective for the TCGA datasets. We believe it can inspire more biomedical researchers to study and explain the genomic alterations in cancer development and discover more targeted therapies to help more cancer patients.

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“…Taking into account that complex mechanisms can control the impact of HSPA2 on the fate of cancer cells, it seems particularly important to evaluate the reliability and usefulness of HSPA2 as a cancer biomarker. So far, a high level of HSPA2 in tumor was reported as a negative prognostic factor in esophageal cancer [ 43 ], hepatocellular cancer [ 44 ], pancreatic cancer [ 45 , 46 ], and NSCLC [ 22 ]. In the case of breast cancers, conflicting results were published.…”

Section: Discussionmentioning

confidence: 99%

HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells

Sojka

Gogler-Pigłowska

Klarzyńska

et al. 2020

Cancers

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Heat Shock Protein A2 (HSPA2) is a member of the HSPA (HSP70) chaperone family and has a critical role for male fertility. HSPA2 is present in a number of somatic organs. Limited evidence suggests that HSPA2 may be involved in regulating epithelial cell differentiation. HSPA2 also emerged as a cancer-related chaperone; however, no consensus on its functional significance has been reached so far. In this study, we compared the phenotypic effects of HSPA2 deficit in non-transformed human bronchial epithelial cells (HBEC), and in lung, breast, and cervical cancer cells. We used various techniques to inhibit the HSPA2 gene expression in order to examine the impact of HSPA2 deficiency on cell growth, migration, adhesion, and invasion. Our results show that HBEC but not cancer cells are sensitive to HSPA2 deficit. HSPA2 knockdown in HBEC cells impaired their clone-forming ability and adhesiveness. Thus, our results indicate that epithelial cells can rely on a specific activity of HSPA2, but such dependence can be lost in epithelial cells that have undergone malignant transformation.

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Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma

Cited by 21 publications

References 15 publications

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

Identification of Gene Expression Pattern Related to Breast Cancer Survival Using Integrated TCGA Datasets and Genomic Tools

HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells

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