2015
DOI: 10.1186/s13000-015-0253-9
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Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma

Abstract: BackgroundIt has been shown that heat shock-related 70-kDa protein 2 (HSPA2), a member of the HSP70 family of heat shock proteins, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression and its prognostic significance in pancreatic cancer remain unknown.MethodsQuantitative reverse transcriptase ploymerase chain reaction (qRT-PCR) was applied to examine HSPA2 messenger RNA (mRNA) expression in 104 pairs of pancreatic cancer tissues and adjacent noncancerous tissues. Statisti… Show more

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Cited by 21 publications
(25 citation statements)
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“…HSPA2 has been found to overexpress in many cancer types. Furthermore, patients with higher HSPA2 expression had shorter overall survival compared with lower HSPA2 patients [ 27 30 ]. These are consistent with our in vitro data that HSPA2 plays an oncogenic role in NSCLC cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…HSPA2 has been found to overexpress in many cancer types. Furthermore, patients with higher HSPA2 expression had shorter overall survival compared with lower HSPA2 patients [ 27 30 ]. These are consistent with our in vitro data that HSPA2 plays an oncogenic role in NSCLC cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…During this process, HSPA2 was found with different characters in our breast cancer data compared with previous reported study in other cancer types. HSPA2 is a member of the HSP70 family of heat shock proteins and is important for cancer cell growth and metastasis [ 19 ]. HSPA2 has been highlighted as an important biomarker in many cancer types.…”
Section: Resultsmentioning
confidence: 99%
“…Taking into account that complex mechanisms can control the impact of HSPA2 on the fate of cancer cells, it seems particularly important to evaluate the reliability and usefulness of HSPA2 as a cancer biomarker. So far, a high level of HSPA2 in tumor was reported as a negative prognostic factor in esophageal cancer [ 43 ], hepatocellular cancer [ 44 ], pancreatic cancer [ 45 , 46 ], and NSCLC [ 22 ]. In the case of breast cancers, conflicting results were published.…”
Section: Discussionmentioning
confidence: 99%